Fungal Endophytes from Medicinal Plants as a Potential Source of Bioactive Secondary Metabolites and Volatile Organic Compounds: An Overview

Nisa, Humeera; Kamili, Azra N.

doi:10.1007/978-3-319-90484-9_29

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…Among the wide biodiversity found in the kingdom of Fungi, endophytes are species capable of growing asymptomatically and colonizing the internal plant tissues [ 20 ]. These species play an important role within plant ecosystems, associated with the symbiotic benefits that many of them produce in their host, especially under stress conditions [ 21 , 22 , 23 ]. Among such benefits, the protection of their host against a wide variety of harmful organisms is one of the most important actions performed by endophytes [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Filtrates and Extracts from Fungal Endophytes on Phytophthora cinnamomi in Lupinus luteus

García-Latorre

Rodrigo

Santamaría

2022

Plants

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Fungal endophytes have been found to protect their hosts against multiple fungal pathogens. Frequently, the secondary metabolites produced by the endophyte are responsible for antifungal activity. To develop new bio-products that are more environmentally friendly than synthetic pesticides against Phytophthora cinnamomi, a serious pathogen of many plant species, the antifungal activity of filtrates or extracts from four endophytes was evaluated in different in vitro tests and in plants of Lupinus luteus. In the dual culture assays, the filtrate of one of the endophytes (Drechslera biseptata) completely inhibited the mycelial growth of the pathogen. Moreover, it showed a very low minimal inhibitory concentration (MIC). Epicoccum nigrum, an endophyte that also showed high inhibitory activity and a low MIC against P. cinnamomi in those two experiments, provided a clear growth promotion effect when the extracts were applied to L. luteus seedlings. The extract of Fusarium avenaceum also manifested such a promotion effect and was the most effective in reducing the disease severity caused by the pathogen in lupine plants (73% reduction). Results demonstrated the inhibitory activity of the filtrates or extracts of these endophytes against P. cinnamomi. A better insight into the mechanisms involved may be gained by isolating and identifying the metabolites conferring this inhibitory effect against this oomycete pathogen.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Filtrates and Extracts from Fungal Endophytes on Phytophthora cinnamomi in Lupinus luteus

García-Latorre

Rodrigo

Santamaría

2022

Plants

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Biosynthesis of resveratrol by an endophytic Priestia megaterium PH3 via the phenylpropane pathway

Zhang,

Ding

et al. 2023

Appl Microbiol Biotechnol

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One-step Bio-guided Isolation of Secondary Metabolites from the Endophytic Fungus Penicillium crustosum Using High-resolution Semi-preparative HPLC

Alfattani

Queiroz

Marcourt

et al. 2024

CCHTS

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Background: An endophytic fungal strain Penicillium crustosum was isolated from the seagrass Posidonia oceanica and investigated to identify its antimicrobial constituents and characterize its metabolome composition. The ethyl acetate extract of this fungus exhibited antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as an anti-quorum sensing effect against Pseudomonas aeruginosa. Methods: The crude extract was profiled by UHPLC-HRMS/MS and the dereplication was assisted by feature-based molecular networking. As a result, more than twenty compounds were annotated in this fungus. To rapidly identify the active compounds, the enriched extract was fractionated by semi-preparative HPLC-UV applying a chromatographic gradient transfer and dry load sample introduction to maximise resolution. The collected fractions were profiled by 1H-NMR and UHPLC-HRMS. Results: The use of molecular networking-assisted UHPLC-HRMS/MS dereplication allowed preliminary identification of over 20 compounds present in the ethyl acetate extract of P. crustosum. The chromatographic approach significantly accelerated the isolation of the majority of compounds present in the active extract. The one-step fractionation allowed the isolation and identification of eight compounds (1-8). Conclusion: This study led to the unambiguous identification of eight known secondary metabolites as well as the determination of their antibacterial properties.

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Fungal Endophytes from Medicinal Plants as a Potential Source of Bioactive Secondary Metabolites and Volatile Organic Compounds: An Overview

Cited by 3 publications

References 60 publications

Protective Effects of Filtrates and Extracts from Fungal Endophytes on Phytophthora cinnamomi in Lupinus luteus

Protective Effects of Filtrates and Extracts from Fungal Endophytes on Phytophthora cinnamomi in Lupinus luteus

Biosynthesis of resveratrol by an endophytic Priestia megaterium PH3 via the phenylpropane pathway

One-step Bio-guided Isolation of Secondary Metabolites from the Endophytic Fungus Penicillium crustosum Using High-resolution Semi-preparative HPLC

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