Fungal deracemization of benzoin

Chiral Enzymatic Activity in Cell Cultures of Taxus Species

“…At pH values of 4.0 and 6.0, the oscillatory behavior was also present, but the opposite enantioselectivity was observed during the reaction course because the (R)-enantiomer was mainly obtained. Enantioselective changes were previously reported when racemic benzoin was deracemized by Rhizopus oryzae at pH 7.5-8.0 and pH 4.0-5.0 [29].…”

Biocatalysis: Synthesis of Chiral Intermediates for Drugs

“…The pH of the medium was used to control the absolute confi guration of the enantiomer produced. Thus, at pH 7.5 -8.5 the ( R ) -enantiomer was obtained in 73 -76% yield and 97% ee, whereas at pH 4 -5 the ( S ) -enantiomer was produced in 71% yield and 85% ee (Demir et al , 2002 ). Deracemization of the racemic α -hydroxy ester ethyl 2 -hydroxy -4 -phenylbutanoate to yield the ( S ) -enatiomer in 85 -90% yield and > 99% ee using whole cells of Candida parapsilosis has been demonstrated (Kato et al , 2002 ;Kato et al , 2003 ).…”

Synthesis, characterization, and antimicrobial activity of palladium(II) and platinum(II) complexes with 2‐substituted benzoxazole ligands

“…Their inhibitory properties with regard to the replication of polioviruses, adenosine deaminase, and casein kinase have been demonstrated [10]. While others are important potent antiviral agents [11,12], many are active components of biocides such as bactericides, fungicides, insecticides, and anticarcinogens [13][14][15]. In addition to their biological importance, these ligands are strongly coordinating agents and form stable complexes with various transition metal ions [16].…”