Fungal colonization of the stomach and its clinical relevance

Zwolińska‐Wciso, Matgonata; Budak, Alicja; Trojanowska, Danuta; Bogda, J.; Stachura, Jerzy

doi:10.1111/j.1439-0507.1998.tb00346.x

Cited by 46 publications

(50 citation statements)

References 24 publications

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“…In one study of 293 patients aged 20 to 80 years, Ͼ50% patients with gastric ulcers and Ͼ10% with chronic gastritis had fungal colonization of the stomach, with C. albicans being the most frequently isolated fungus (50). In three separate studies of 188, 66, and 42 adult patients with benign gastric ulcers, C. albicans infiltration into the gastric lesions were identified in 7, 9, and 36% of the patients, respectively (12,14,26).…”

Section: Discussionmentioning

confidence: 99%

Interplay between the Gastric Bacterial Microbiota and Candida albicans during Postantibiotic Recolonization and Gastritis

et al. 2012

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The indigenous bacterial microbiome of the stomach, including lactobacilli, is vital in promoting colonization resistance against Candida albicans. However, there are gaps in our understanding about C. albicans gastric colonization versus disease, especially during the postantibiotic recovery phase. This study compared the gastric responses to C. albicans strains CHN1 and SC5314 in microbiome-disturbed and germfree mice to elucidate the contribution of the indigenous microbiota in C. albicans colonization versus disease and yeast-bacterium antagonism during the post-cefoperazone recolonization period. C. albicans can prevent the regrowth of Lactobacillus spp. in the stomach after cefoperazone and promote increased colonization by Enterococcus spp. Using a culture-independent analysis, the effects of oral cefoperazone on the gastric bacterial microbiota were observed to last at least 3 weeks after the cessation of the antibiotic. Disturbance of the gastric bacterial community by cefoperazone alone was not sufficient to cause gastritis, C. albicans colonization was also needed. Gastritis was not evident until after day 7 in cefoperazonetreated infected mice. In contrast, in germfree mice which lack a gastric microbiota, C. albicans induced gastric inflammation within 1 week of inoculation. Therefore, the gastric bacterial community in cefoperazone-treated mice during the first week of postantibiotic recolonization was sufficient to prevent the development of gastritis, despite being ineffective at conferring colonization resistance against C. albicans. Altogether, these data implicate a dichotomy between C. albicans colonization and gastric disease that is bacterial microbiome dependent.

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Section: Discussionmentioning

confidence: 99%

Interplay between the Gastric Bacterial Microbiota and Candida albicans during Postantibiotic Recolonization and Gastritis

et al. 2012

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“…In another study, the curability of gastric ulcers infected with Candida was low-30% after a follow-up period of 6 months or more [2]. The Candida-positive rate was reportedly over 54% in patients with gastric ulcers from a study group in Poland [3]. Although it has been speculated that Candida infection affects the healing of an ulcer, the association between Candida infection and peptic ulcers remains controversial.…”

Section: Introductionmentioning

confidence: 96%

Candida albicans Infection Delays Duodenal Ulcer Healing in Cysteamine-Induced Duodenal Ulcers in Rats

et al. 2008

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A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group (P < 0.05). The duodenal ulcer in the Candida group was significantly larger and deeper than that in the control group. The number of VEGF-A- and PCNA-positive cells was smaller and the area of VEGF-A expression was lower in the Candida group. Using a rat model, we have demonstrated that Candida infection can delay the wound healing process of duodenal ulcers by means of a low expression of VEGF-A and PCNA.

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“…In fact, C. albicans hyphae visualized in infected tissues are very sparsely branched [6,36,51,52,63] because the subapical compartments of hyphae are arrested in the G1 phase of the cell cycle [12,45]. (iii) Increasing pH (to 8.0) or CO 2 concentration (to 5% at pH 7.0) in the presence of hemin also increases the branching time ( Figures 2 and 4, Supplementary Materials 1 and 2), which indicates that under environmental conditions reminiscent of that found in the intestine especially in the case of bleeding/ulceration [16,22,[64][65][66], the invasiveness of C. albicans should increase. Further studies are needed to answer the intriguing question if the nutrients available in the intestinal lumen and the composition of the intestinal gases (e.g., the considerably decreased O 2 tension) would support predominantly yeast morphology with a commensal lifestyle or also Y → H morphological transitions preparing the fungus for the invasion of intestinal mucosa [24,67].…”

Section: Discussionmentioning

confidence: 95%

Effects of hemin, CO2, and pH on the branching of Candida albicans filamentous forms

Jakab

Antal

Emri

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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Morphological transitions of wild-type and oxidative stress-tolerant Candida albicans strains were followed in the RPMI-FBS culture medium at pH values and CO 2 levels characteristic for the anatomical niches inhabited by this opportunistic human pathogen fungus, including the oral cavity as well as the intestinal and vaginal lumens. Selected cultures were also supplemented with hemin modeling bleedings. Germination as well as elongation and branching of hyphae were monitored in the cultures using time-lapse video microscopy. Unexpectedly, branching time, which is defined as the time taken until the first branch of hypha emerges for the first time after germination, correlated well with alterations in the environmental conditions meanwhile no such correlations were found for germination time (time lasted until the *Corresponding author; E-mail: pocsi.istvan@science.unideb.hu : 10.1556/030.63.2016.023 First published online December 8, 2016 1217-8950/$ 20.00 © 2016 Akadémiai Kiadó, Budapest appearance of the germination tube). Based on these observations, hypotheses were set up to estimate the significance of branching time in the pathogenesis of both superficial and systemic candidiases.Acta Microbiologica et Immunologica Hungarica 63 (4), pp. 387-403 (2016) DOI

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Fungal colonization of the stomach and its clinical relevance

Cited by 46 publications

References 24 publications

Interplay between the Gastric Bacterial Microbiota and Candida albicans during Postantibiotic Recolonization and Gastritis

Interplay between the Gastric Bacterial Microbiota and Candida albicans during Postantibiotic Recolonization and Gastritis

Candida albicans Infection Delays Duodenal Ulcer Healing in Cysteamine-Induced Duodenal Ulcers in Rats

Effects of hemin, CO2, and pH on the branching of Candida albicans filamentous forms

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