Fungal Colitis by Paracoccidioides brasiliensis: a case report

Galeazzi, Carlos José; Estofolete, Cássia Fernanda; Filho, Antônio Carlos Soares de Moraes; Simoni, Anderson Lubito; Gonçalves-Filho, Francisco de Assis; Netinho, João Gomes

doi:10.1590/s2237-93632011000400013

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Together, clinical manifestations and colonoscopic and histological findings can clearly simulate Crohn’s disease. Biopsy is indispensable to complete the diagnosis and to introduce specific treatment [ 14 ]. The treatment is long, the drugs may have undesirable side effects, and the first choice is sulfamethoxazole-trimethoprim [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Intestinal paracoccidioidomycosis resembling Crohn’s disease in a teenager: a case report

et al. 2018

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BackgroundDifferential diagnosis of inflammatory bowel disease is often very challenging. Paracoccidioidomycosis is a fungal disease that can mimic manifestations of Crohn’s disease.Case presentationWe report a case of a 13-year-old Caucasian boy with abdominal pain for 1.5 years associated with nausea, diarrhea, and weight loss of 10 kg. He presented increased C-reactive protein and an increased erythrocyte sedimentation rate. A colonoscopy showed deep serpiginous ulcers throughout his entire colon and rectum, which suggested Crohn’s disease. He received one dose of infliximab, which is an anti-tumor necrosis factor-α, and showed no improvement. After the second dose, he got worse and started to have bloody diarrhea. A new colonoscopy was performed and pathological examination revealed ulcerative chronic inflammation with non-caseating granulomas and fungal structures (budding forms) compatible with Paracoccidioides brasiliensis. He underwent intravenously administered and then orally administered trimethoprim-sulfamethoxazole treatment. Due to drug intolerance, he was treated with amphotericin B and itraconazole, then he showed clinical improvement and mucosal healing with good outcome.ConclusionParacoccidioidomycosis must be part of the differential diagnosis of inflammatory bowel diseases in endemic areas and must be excluded before starting immunosuppressive therapy.

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Section: Discussionmentioning

confidence: 99%

Intestinal paracoccidioidomycosis resembling Crohn’s disease in a teenager: a case report

et al. 2018

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Intestinal Paracoccidioidomycosis: Case report and systematic review

Cruz

Forno

Pacheco

et al. 2021

The Brazilian Journal of Infectious Diseases

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Paracoccidioidomicose juvenil: apresentação atípica e disseminada em adulto do sexo feminino.

Maia¹,

Guedes²,

Noronha³

et al. 2019

CadUniFOA

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Paracoccidioidomicose é uma doença micótica sistêmica causada por um fungo termodimórfico do gênero Paracoccidioides, também conhecida no passado como doença de Lutz ou Blastomicose Sul-Americana. Com maior ocorrência nas regiões Sul, Sudeste e Centro-oeste principalmente em zona rural e em locais de desmatamento recente. O caso reportado ocorreu no município de Valença-RJ e contraria o perfil epidemiológico e de manifestação clínica mais comum da doença. Neste relato discutimos a importância do diagnóstico diferencial, a instituição do tratamento correto e analisamos a diferença de ocorrência da doença entre os sexos.

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Fungal Colitis by Paracoccidioides brasiliensis: a case report

Cited by 3 publications

References 7 publications

Intestinal paracoccidioidomycosis resembling Crohn’s disease in a teenager: a case report

Intestinal paracoccidioidomycosis resembling Crohn’s disease in a teenager: a case report

Intestinal Paracoccidioidomycosis: Case report and systematic review

Paracoccidioidomicose juvenil: apresentação atípica e disseminada em adulto do sexo feminino.

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