Fundus Image Based Blood Flow Simulation of the Retinal Arteries

Kristen, Andreas; Kelsey, Lachlan J.; Wintermantel, E.; Doyle, Barry

doi:10.1007/978-3-319-28329-6_13

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Pulsatile simulations will significantly increase the computational times, but will create more accurate transient data allowing for WSS to be averaged over a cardiac cycle. Furthermore, a structured fractal tree (Kristen et al 2016;Olufsen et al 2000) or resistor boundary conditions could be implemented at the outlets to enhance the model. We aim to pursue these advancements to further refine our methodology in future work.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Viscosity and haemodynamics in a late gestation rat feto-placental arterial network

Bappoo

Kelsey

Parker

et al. 2017

Biomech Model Mechanobiol

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The placenta is a transient organ which develops during pregnancy to provide haemotrophic support for healthy fetal growth and development. Fundamental to its function is the healthy development of vascular trees in the feto-placental arterial network. Despite the strong association of haemodynamics with vascular remodelling mechanisms, there is a lack of computational haemodynamic data that may improve our understanding of feto-placental physiology. The aim of this work was to create a comprehensive 3D computational fluid dynamics model of a substructure of the rat feto-placental arterial network and investigate the influence of viscosity on wall shear stress (WSS). Late gestation rat feto-placental arteries were perfused with radiopaque Microfil and scanned via micro-computed tomography to capture the feto-placental arterial geometry in 3D. A detailed description of rat fetal blood viscosity parameters was developed, and three different approaches to feto-placental haemodynamics were simulated in 3D using the finite volume method: Newtonian model, non-Newtonian Carreau-Yasuda model and Fåhræus-Lindqvist effect model. Significant variability in WSS was observed between different viscosity models. The physiologically-realistic simulations using the Fåhræus-Lindqvist effect and rat fetal blood estimates of viscosity revealed detailed patterns of WSS throughout the arterial network. We found WSS gradients at bifurcation regions, which may contribute to vessel enlargement, and sprouting and pruning during angiogenesis. This simulation of feto-placental haemodynamics shows the heterogeneous WSS distribution throughout the network and demonstrates the ability to determine physiologically-relevant WSS magnitudes, patterns and gradients. This model will help advance our understanding of vascular physiology and remodelling in the feto-placental network.

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Section: Limitations Of the Studymentioning

confidence: 99%

Viscosity and haemodynamics in a late gestation rat feto-placental arterial network

Bappoo

Kelsey

Parker

et al. 2017

Biomech Model Mechanobiol

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Image-Based Retinal Haemodynamics Simulation of Healthy and Pathological Retinal Vasculature

Gupta,

Bhandari

2024

Lecture Notes in Mechanical Engineering

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One-dimensional modeling of microvascular hemodynamics in the retina using multimodal imaging

et al. 2023

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Modeling techniques are an essential complement to clinical studies of the retina, as they provide access to non-measurable parameters throughout the network and enable the simulation of controlled disturbances or pathologies. In this work, we propose the development of a patient-specific one-dimensional model of the arterial circulation in the retina. Our model is based on conservation laws and utilizes morphometric and velocimetric data obtained through clinical multimodal imaging to construct the network topology and impose realistic boundary conditions. Specifically, our model simulates blood flow from the central retina artery to the terminal smallest arterioles. To validate our model, we perform a sensitivity analysis and compare its results to published data. Finally, we use our model to investigate the hemodynamic consequences of focal stenosis on retinal arteries. Overall, our model provides a valuable tool for exploring the complex dynamics of retinal blood flow and their potential clinical implications.

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Fundus Image Based Blood Flow Simulation of the Retinal Arteries

Cited by 3 publications

References 28 publications

Viscosity and haemodynamics in a late gestation rat feto-placental arterial network

Viscosity and haemodynamics in a late gestation rat feto-placental arterial network

Image-Based Retinal Haemodynamics Simulation of Healthy and Pathological Retinal Vasculature

One-dimensional modeling of microvascular hemodynamics in the retina using multimodal imaging

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