Fundus autofluorescence as a marker of disease severity in Vogt–Koyanagi–Harada disease

Morita, Celso; Sakata, Viviane Mayumi; Rodriguez, Ever Ernesto Caso; Abdallah, Smairah Frutuoso; Lavezzo, Marcelo Mendes; Silva, Felipe T. da; Machado, Cleide Guimarães; Oyamada, Maria Kiyoko; Hirata, Carlos Eduardo; Yamamoto, Jiro

doi:10.1111/aos.13147

Cited by 14 publications

(12 citation statements)

References 5 publications

(7 reference statements)

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“…Extensive choroidal inflammation and exudative retinal detachment (ERD) are the major fundus manifestations of VKH at the acute uveitic stage [ 15 , 16 ]. Starting from the choroid, the lesion soon affects the retina, leading to ERD in some positions; even the non-detached regions may show inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage

Zhao

Pang

et al. 2018

Med Sci Monit

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BackgroundThis study analyzed the macular 3D-OCT images of Vogt-Koyanagi-Harada disease (VKH) in uveitis, explored the characteristics of 3D-OCT images of the macular region of VKH, and assessed which characteristics contribute most to VKH diagnosis.Material/MethodsThe 3D-OCT examination of 25 cases of VKH was performed on the macular area, and the image characteristics were analyzed.ResultsOur study included a total of 50 eyes from 25 cases of VKH patients, 10 males and 15 females, aged 17 to 64 years, mean (39.44±11.60) years old. According to OCT B-scan images, 49 (98%) eyes had ERD, 49 (98%) eyes had nerve retinal edema, 36 (72%) eyes had endometrium-like structure (including cysts), 5 (10%) eyes had RPE folds, 35 (70%) eyes had changes in the internal septum, 49 (98%) eyes had RPE monolayer structure outside the ERD region. In ILM-RPE thickness, 49 (98%) eyes had retinal irregular thickening and 31 (62%) eyes had radial stripe changes. In ILM contour figure, 50 eyes (100%) showed exceptional uplift, 5 (10%) eyes had small focal uplift for PED on the RPE surface, and 48 (96%) eyes had wavy ups and downs.ConclusionsIn OCT B-scan imaging, the ERT, retinal edema of the retina, and the RPE monolayer structure outside the range are most likely to occur in VKH. The ILM-RPE thickness chart in 3D reconstruction showed irregular thickening of the retina. The ILM contour graph showed abnormal uplift, and RPE surface wavy ups and downs in VKH most likely to occur.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage

Zhao

Pang

et al. 2018

Med Sci Monit

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“…Fundus autofluorescence (FAF) has also been used to evaluate severity of VKH (Morita et al. ), and we plan to compare FAF and MSI to observe RPE changes of patients with VKH in future studies. The study reported here adds to the various possible applications of MSI in the field of retinal diseases, although further research is needed to demonstrate whether this innovative technology deserves a place in everyday ophthalmic practice.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, MSI appears equivalent to fundus autofluorescence (FAF) and near-infrared reflectance in identifying reticular pseudodrusen (RPD) in age-related macular degeneration (AMD) patients (Alten et al 2014). Fundus autofluorescence (FAF) has also been used to evaluate severity of VKH (Morita et al 2016), and we plan to compare FAF and MSI to observe RPE changes of patients with VKH in future studies. The study reported here adds to the various possible applications of MSI in the field of retinal diseases, although further research is needed to demonstrate whether this innovative technology deserves a place in everyday ophthalmic practice.…”

Section: Discussionmentioning

confidence: 99%

Multispectral image analysis in Vogt–Koyanagi–Harada disease

Guo

Peng

et al. 2017

Acta Ophthalmologica

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“…Lipofuscin granules accumulate with age in postmitotic RPE lysosomal compartments as phagocytotic remnants of photoreceptor outer segment discs (Feeney-Burns et al 1980;Weiter et al 1986;Kennedy et al 1995;Katz et al 1996;Sparrow & Boulton 2005;Morita et al 2016;Schmidt et al 2017). Lipofuscin granules accumulate with age in postmitotic RPE lysosomal compartments as phagocytotic remnants of photoreceptor outer segment discs (Feeney-Burns et al 1980;Weiter et al 1986;Kennedy et al 1995;Katz et al 1996;Sparrow & Boulton 2005;Morita et al 2016;Schmidt et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…There is considerable interest in the effect of lipofuscin on RPE function and its role in retinal diseases. Lipofuscin granules accumulate with age in postmitotic RPE lysosomal compartments as phagocytotic remnants of photoreceptor outer segment discs (Feeney-Burns et al 1980;Weiter et al 1986;Kennedy et al 1995;Katz et al 1996;Sparrow & Boulton 2005;Morita et al 2016;Schmidt et al 2017). Previous studies suggest that lipofuscin and its constituent A2E may exert toxic effects on normal RPE cellular processes (Young 1987;Boulton et al 1989;Holz et al 1999;Delori et al 2000;Sparrow et al 2003;Zhou et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Fundus autofluorescence imaging in hereditary retinal diseases

Pichi

Abboud

Ghazi

et al. 2017

Acta Ophthalmologica

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Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to non-invasively map changes at the level of the retinal pigment epithelium (RPE)/photoreceptor complex and alterations of macular pigment distribution. This imaging method is based on the visualization of intrinsic fluorophores and may be easily and rapidly used in routine patient care. Excessive accumulation of lipofuscin granules in the lysosomal compartment of RPE cells represents a common downstream pathogenic pathway in various hereditary and complex retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating macular dystrophies and various hereditary retinal disorders. Fundus autofluorescence (FAF) may detect abnormalities beyond those detected on funduscopic examination, fluorescein angiography (FA) or optical coherence tomography (OCT). Fundus autofluorescence (FAF) imaging is particularly helpful for differential diagnosis, detection and extent delineation of involved retinal areas, genotype-phenotype correlations and monitoring of changes overtime. Given its ease of use, non-invasive nature and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes basic principles and FAF findings in various hereditary retinal diseases.

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Fundus autofluorescence as a marker of disease severity in Vogt–Koyanagi–Harada disease

Cited by 14 publications

References 5 publications

Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage

Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage

Multispectral image analysis in Vogt–Koyanagi–Harada disease

Fundus autofluorescence imaging in hereditary retinal diseases

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