Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm

Osman, Mamat; Fukumura, Yuki; Saito, Tsuyoshi; Takahashi, Michiko; Mitomi, Hiroyuki; Sai, Jin Kan; Kawasaki, Seiji; Yao, Takashi

doi:10.1111/his.12967

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…7). We also conducted a somatic mutation analysis of G-protein αs (GNAS) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), as described previously (4). We analyzed The patient was followed for 10 months after resection; during this period, recurrence did not occur.…”

Section: Case Reportmentioning

confidence: 99%

Mucinous Cystadenocarcinoma of the Pancreas with Cyst Infection in a Male Patient

et al. 2020

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Follow-up computed tomography revealed a 40-mm pancreatic tail cyst in a 59-year-old man with type 1 diabetes mellitus. An intraductal papillary mucinous neoplasm was suspected; mucinous cystic neoplasm (MCN) was not considered because the patient was a man. During follow-up, cyst infection occurred but was improved by conservative treatment. At the 24-month follow up examination, cyst nodules had developed, corresponding to an increase in the carbohydrate antigen 19-9 level. Mucinous cystadenocarcinoma (MCC) was diagnosed pathologically based on distal pancreatectomy. A diagnosis of male MCN/MCC is often delayed, which may lead to a poor prognosis. MCN infection is also rare and poorly recognized. We observed an atypical male case of MCN/MCC.

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Section: Case Reportmentioning

confidence: 99%

Mucinous Cystadenocarcinoma of the Pancreas with Cyst Infection in a Male Patient

et al. 2020

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“…Although they have some histological similarity to PGAs of the stomach, duodenum, and pancreas, the underlying molecular abnormalities are different; gallbladder PGAs frequently have the CTNNB1 mutation and exceptionally or only rarely have the KRAS mutation, and they lack the GNAS mutation. On the contrary, PGAs of the stomach, duodenum, and pancreas frequently have KRAS and GNAS mutations [ 24 , 25 , 26 , 27 ].…”

Section: Pyloric Gland Adenomamentioning

confidence: 99%

Precursor Lesions of Gallbladder Carcinoma: Disease Concept, Pathology, and Genetics

et al. 2022

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Understanding the pathogenesis and carcinogenesis of gallbladder adenocarcinoma is important. The fifth edition of the World Health Organization’s tumor classification of the digestive system indicates three types of preinvasive neoplasm of the gallbladder: pyloric gland adenoma (PGA), biliary intraepithelial neoplasia (BilIN), and intracholecystic papillary neoplasm (ICPN). New terminologies have also been introduced, such as intracholecystic papillary-tubular neoplasm, gastric pyloric, simple mucinous type, and intracholecystic tubular non-mucinous neoplasm (ICTN). Pancreatobiliary maljunction (PBM) poses a markedly high risk for bile duct carcinoma, which was analyzed and investigated mainly by Asian researchers in the past; however, recent studies have clarified a similar significance of biliary carcinogenesis in Western countries as well. In this study, we reviewed and summarized information on three gallbladder neoplastic precursors, PGA, BilIN, and ICPN, and gallbladder lesions in patients with PBM.

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“…According to a recent study from our group, pancreatic PGAs did not show fundic gland differentiation; however the sample number was small. 16 In this study, no GB-PGA cases showed fundic gland differentiation, which was evaluated through pepsinogen I immunoreactivity.…”

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confidence: 91%

“…[10][11][12][13][14] In cases of pancreatic PGAs, or IPMN-PGs, high frequencies of GNAS/KRAS mutations have also been reported. 15,16 In contrast, only limited numbers of published studies are available on gallbladder PGAs (GB-PGAs), with respect to the histological variation, phenotypic differentiation, and, in particular, the molecular status of this neoplasm. Hence, to better understand GB-PGA, we aimed to investigate clinicopathological and immunohistochemical features as well as molecular status of this neoplasm by comparing with the reported data of those of stomach, duodenum and pancreatic PGAs (SDP-PGAs).…”

Section: Introductionmentioning

confidence: 99%

Pyloric Gland Adenoma (PGA) of the Gallbladder

Cong

Fukumura

Toriyama

et al. 2018

American Journal of Surgical Pathology

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Twenty-four surgically resected, gallbladder pyloric gland adenomas (GB-PGAs) were examined and their features were compared with the reported features of stomach, duodenum, and pancreatic PGAs to better understand GB-PGAs. Clinical information on background gallbladder lesions and histologic data, including tumor grade, existence of squamoid morules, intratumoral cholesterosis, and intracytoplasmic mucins were collected. Immunohistochemical staining for MUC2, MUC5AC, MUC6, CDX2, pepsinogen I, p53, and MIB-1/nuclear β-catenin were evaluated. Targeted mutational analyses of KRAS exon2, GNAS exon 7, and CTNNB1 exon 3 were conducted. We found that 29.2% of the GB-PGAs were histologically high-grade dysplasias/carcinomas; 70.8% were low grade; and 20.8% and 33.3% contained squamoid morules and intratumoral cholesterosis, respectively. In addition, 45.8% and 54.2% of GB-PGAs were mucin-rich and mucin-poor types, respectively. Immunohistochemically, MUC6 was diffusely positive in all GB-PGAs; MUC2, MUC5AC, and CDX2 were only focally positive, and no pepsinogen-I positive cells were observed. Nuclear β-catenin accumulation was observed in all cases; however, the ratio varied among cases. Mucin-poor types were significantly associated with high histologic grade dysplasias/carcinomas and high nuclear β-catenin labeling indices. Mutational analyses identified CTNNB1 mutations in 100% of GB-PGAs (21/21), KRAS in 4.2% (1/23), and GNAS in 0% (0/22). The present study clarified the unique histologic features, phenotypic differentiation, and molecular statuses frequently associated with GB-PGAs. Altogether, our data suggest that tumorigenesis of GB-PGA is distinct from that of stomach, duodenum, and pancreatic PGAs.

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Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm

Abstract: The differentiation of IPMNs to gastric FG is related to oncocytic and pancreatobiliary subtypes, and to high grade. This is the first report to describe differentiation of IPMNs to the FG, and to reveal its relationship with the clinicopathological features of IPMNs.

Cited by 6 publications

References 29 publications

Mucinous Cystadenocarcinoma of the Pancreas with Cyst Infection in a Male Patient

Mucinous Cystadenocarcinoma of the Pancreas with Cyst Infection in a Male Patient

Precursor Lesions of Gallbladder Carcinoma: Disease Concept, Pathology, and Genetics

Pyloric Gland Adenoma (PGA) of the Gallbladder

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