Fundamentals of the modern theory of the phenomenon of “pain” in terms of a systematic approach to issues its psychological component. Terminology of the systemic approach and a brief representation of the human body as a system

Shvidyuk

et al. 2019

The phenomenon of “pain” is a psychophysiological phenomenon that is actualized in the mind of a person as a result of the systemic response of his body to certain external and internal stimuli. The heart of the corresponding mental processes is certain neurophysiological processes, which in turn are caused by a certain form of the systemic structural and functional organization of the central nervous system (CNS). Thus, the systemic structural and functional organization of the central nervous system of a person, determining the corresponding psychophysiological state in a specific time interval, determines its psycho-emotional states or reactions manifested by the pain phenomenon. The nervous system of the human body has a hierarchical structure and is a morphologically and functionally complete set of different, interconnected, nervous and structural formations. The basis of the structural formations of the nervous system is nervous tissue. It is a system of interconnected differentials of nerve cells, neuroglia and glial macrophages, providing specific functions of perception of stimulation, excitation, generation of nerve impulses and its transmission. The neuron and each of its compartments (spines, dendrites, catfish, axon) is an autonomous, plastic, active, structural formation with complex computational properties. One of them – dendrites – plays a key role in the integration and processing of information. Dendrites, due to their morphology, provide neurons with unique electrical and plastic properties and cause variations in their computational properties. The morphology of dendrites: 1) determines – a) the number and type of contacts that a particular neuron can form with other neurons; b) the complexity, diversity of its functions; c) its computational operations; 2) determines – a) variations in the computational properties of a neuron (variations of the discharges between bursts and regular forms of pulsation); b) back distribution of action potentials. Dendritic spines can form synaptic connection – one of the main factors for increasing the diversity of forms of synaptic connections of neurons. Their volume and shape can change over a short period of time, and they can rotate in space, appear and disappear by themselves. Spines play a key role in selectively changing the strength of synaptic connections during the memorization and learning process. Glial cells are active participants in diffuse transmission of nerve impulses in the brain. Astrocytes form a three-dimensional, functionally “syncytia-like” formation, inside of which there are neurons, thus causing their specific microenvironment. They and neurons are structurally and functionally interconnected, based on which their permanent interaction occurs. Oligodendrocytes provide conditions for the generation and transmission of nerve impulses along the processes of neurons and play a significant role in the processes of their excitation and inhibition. Microglial cells play an important role in the formation of the brain, especially in the formation and maintenance of synapses. Thus, the CNS should be considered as a single, functionally “syncytia-like”, structural entity. Because the three-dimensional distribution of dendritic branches in space is important for determining the type of information that goes to a neuron, it is necessary to consider the three-dimensionality of their structure when analyzing the implementation of their functions.

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Fundamentals of the modern theory of the phenomenon of "pain" from the perspective of a systematic approach. Neurophysiological basis. Part 1: A brief presentation of key subcellular and cellular ctructural elements of the central nervous system.

Shvidyuk

et al. 2019

To the basics of clinical thinking formalization. Main terms with conceptual meaning

Katilov

et al. 2020

Medicine’s condition is one of the most relevant scientific and socio-economic problems of the mankind. Eclecticism, presence of multiple contradictions and compilations are typical at the modern stage of it as of a knowledge system. First of all, this state of medicine is conditioned by the absence of systematic structural and functional organization of the human body in the medical scientific and practical activity. Formation of the systematic thinking on the basis of the knowledge about human body as a system is necessary for the solution of this problem. The system of special meanings forms scientific knowledge that determines the form and corresponding thinking method. Knowledge is a reflection of objective reality in our consciousness, represented in symbols of the formal language matrix. Clinical thinking – specialized form of the internal speech. Its structural units are corresponding definitions, terms and notions. At the same time they are its tools and methods. Certain group of terms has a conceptual meaning for the formation and development of clinical thinking.

Basic concepts and physical-chemical phenomena, that have conceptual meaning for the formation of systemic clinical thinking and formalization of the knowledge of systemic structural-functional organization of the human’s organism

Katilov

et al. 2020

From the point of view of perception and generalization processes there are complex, logic and conceptual forms of thinking. Its conceptual form is the highest result of interaction between thinking and speech. While realizing it, human uses the concept, which are logically formed thoughts, that are the meaning of representation in thinking of unity of meaningful features, relations of subjects or phenomena of objective reality. Special concepts, that are used in the science and technique are called terms. They perform a function of corresponding, special, precise marking of subjects and phenomena, their features and interactions. Scientific knowledge are in that way an objective representation of material duality in our consciousness. Certain complex of terms forms a terminological system, that lies in the basis of corresponding sphere of scientific knowledge and conditions a corresponding form and way of thinking. Clinical thinking is a conceptual form, that manifests and represents by the specialized internal speech with gnostic motivation lying in its basis. Its structural elements are corresponding definitions, terms and concepts. Cardinal features of clinical systems are consistency, criticality, justification and substantiation. Principles of perception and main concepts are represented in the article along with short descriptions of physical and chemical phenomena, that have conceptual meaning for the formation of systematic clinical thinking and formalization of systemic structural-functional organization of the human’s organism