Fundamentals of protein and cell interactions in biomaterials

Aiyelabegan, Hammed Tanimowo; Sadroddiny, Esmaeil

doi:10.1016/j.biopha.2017.01.136

Cited by 59 publications

(50 citation statements)

References 157 publications

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“…[10] Therefore, the embedding and manipulation of cancer cell spheroids within a polymeric matrix has been a focus to study tumor growth, invasion, and migration and also to evaluate drug response. However, in tumors, the biomechanical, biophysical, and biochemical cues of the surrounding ECM have a crucial role in cell behavior and tissue homeostasis.…”

Section: Natural Biomaterialsmentioning

confidence: 99%

“…However, in tumors, the biomechanical, biophysical, and biochemical cues of the surrounding ECM have a crucial role in cell behavior and tissue homeostasis. [10] Therefore, the embedding and manipulation of cancer cell spheroids within a polymeric matrix has been a focus to study tumor growth, invasion, and migration and also to evaluate drug response. [40,92,93] Charoen et al produced U2OS osteosarcoma and MDA-MB-231 breast adenocarcinoma spheroids and embedded them into matrices of different type I collagen contents.…”

Section: Natural Biomaterialsmentioning

confidence: 99%

“…[1] Primary OS mainly arise in the long bones of the extremities, with higher incidence in the distal femur, proximal tibia, and proximal humerus. The accumulation of these DOI: 10.1002/adtp.201800108 alterations leads to the emergence of cancer stem cells (CSCs) subpopulations with selfrenewal and differentiation capacity, MSC markers expression and increased DNA repair ability, sustaining tumor growth, recurrence, metastasis and drug resistance. [3,4] OS origin is attributed to several epigenetic and/or genetic alterations in mesenchymal stem cells (MSCs) or MSC-derived osteogenic lineages, such as mutation of p53 and retinoblastoma tumor suppressor gene inactivation, under the influence of specific bone microenvironment signals.…”

Section: Introductionmentioning

confidence: 99%

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Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Monteiro

Custódio

Mano

2018

Advanced Therapeutics

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Osteosarcoma (OS) is the most common primary malignant tumor of bone that mainly affects children and adolescents. The currently available therapies are not effective and the search for new OS anticancer drugs is extremely urgent. Understanding the mechanisms that underlie the tumor progression, invasion, and metastasis is an essential step toward effective cancer therapies. Tissue engineering has given a great contribution to the development of reliable and cost-effective platforms for drug screening and validation through 3D in vitro models that more faithfully mimic the in vivo pathophysiology than conventional 2D models. The progress in the field of functional and biomimetic biomaterials in the development of 3D tissue models has provided tools for a close recapitulation of the highly complex and dynamic tumor microenvironment. This review focuses on the most recent advances in 3D in vitro osteosarcoma models, highlighting the crucial role of the extracellular matrix and stromal cells in tumor progression, how they contribute to drug resistance and disease prevalence, and the future pathways toward an effective and personalized model for drug screening and validation.

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Section: Natural Biomaterialsmentioning

confidence: 99%

Section: Natural Biomaterialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Monteiro

Custódio

Mano

2018

Advanced Therapeutics

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“…The ECM provides specific cell adhesion, which promotes a series of biological cellular activities that result in the formation of focal adhesion plaques. The ECM not only improves the cell–alloy adhesion, but it also transduces the chemical signals into the cells . Type I collagen is one of the components in ECM and it is the most abundant protein of the human body consisting of three polypeptide chains.…”

mentioning

confidence: 99%

“…The ECM not only improves the cell-alloy adhesion, but it also transduces the chemical signals into the cells. 21 Type I collagen is one of the components in ECM and it is the most abundant protein of the human body consisting of three polypeptide chains. Each polypeptide chain is composed of at least one Gly-X-Y sequence where the X and Y positions are usually proline and hydroxyproline, respectively, in a left-handed α-like helices structure.…”

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confidence: 99%

Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Huang

Ulloa

Nauman

et al. 2019

Journal Orthopaedic Research

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Bioresorbable iron‐manganese alloys (Fe‐30%Mn) are considered as one of the next‐generation resorbable materials for orthopedic applications. Previous in vitro study showed that Fe30Mn scaffolds with 10% porosity displayed strong mechanical properties and adequate degradation rate without severe cytotoxicity effect. However, the cellular compatibility of these alloys in terms of cell‐to‐cell and alloy‐to‐cell interactions is not ideal. Collagen is the most abundant protein in human bone, providing structural support beneficial to bone healing. We hypothesized that coating collagen on Fe30Mn can improve osteointegration or activities promoting cell adhesion, migration, and proliferation, as the alloy degrades. After preparing collagen coating on Fe‐30Mn via spin coating, we conducted a corrosion test and a direct cytotoxicity test on four Fe30Mn groups: non‐porous and 10% porosity, with and without collagen coating. Furthermore, we evaluated and compared the morphologies of cells over a period of 7 days. Results showed that there was no significant difference between the collagen‐coated and non‐coated groups in corrosion rates, yet a significant decrease from the porous non‐coated group to the porous collagen‐coated group in cytotoxicity level was found. Cell morphology on the porous non‐coated group displayed round shape, whereas that on the porous collagen‐coated group displayed flattened spreading. The study showed that the collagen coating significantly increased the initial cell viability and adhesion for both the porous and non‐porous groups without impeding their degradation rates. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:523–535, 2020

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Remote Tuning of Built‐In Magnetoelectric Microenvironment to Promote Bone Regeneration by Modulating Cellular Exposure to Arginylglycylaspartic Acid Peptide

Liu

Zhang

Yan

et al. 2020

Adv Funct Materials

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Mimicking the endogenous physical microenvironment is a promising strategy for biomaterial‐mediated tissue regeneration. However, precise control of physical cues such as electric/magnetic fields within extracellular environments to facilitate tissue regeneration remains a formidable challenge. Here, remote tuning of the magnetoelectric microenvironment is achieved by a built‐in CoFe2O4/poly(vinylidene fluoridetrifluoroethylene) [P(VDF‐TrFE)] magnetoelectric membrane for effective bone regeneration. The magnetoelectric microenvironment from the nanocomposite membranes promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BM‐MSCs) and enhances bone defect regeneration by increasing cellular exposure and integrin binding to arginylglycylaspartic acid peptide, as predicted by molecular dynamics simulations. Moreover, BM‐MSCs are directed to the osteogenic lineage by osteoimmuomodulation which involves accelerating transition from an initial inflammatory immune response to a pro‐healing regenerative immune response. This work offers a strategy to mimic the magnetoelectric microenvironment for achieving precise and effective tissue regenerative therapies, as well as provides fundamental insights into the biological effects driven by the built‐in magnetoelectric membrane, which can be remotely tuned to precisely modulate osteogenesis in situ.

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Fundamentals of protein and cell interactions in biomaterials

Cited by 59 publications

References 157 publications

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Remote Tuning of Built‐In Magnetoelectric Microenvironment to Promote Bone Regeneration by Modulating Cellular Exposure to Arginylglycylaspartic Acid Peptide

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