Fundamentals of Hydroxyapatite and Related Calcium Phosphates

LeGeros, Racquel Z.; Ito, Atsuo; Ishikawa, Kunio; Tanaka, Sakae; LeGeros, John P.

doi:10.1002/9780470891315.ch2

Cited by 65 publications

(110 citation statements)

References 83 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…In their work, increasing CO 3 for PO 4 substitution (coupled with Na for Ca substitution) in type B apatite was shown to reduce the crystallinity and alter the morphology of the carbonate apatite crystals. Such changes in crystallinity can affect the environment of the O–H groups, from a defined, restricted environment to less defined, less restricted environment which cause the reduction in intensity or absence of some IR absorption bands . With carbonate addition, the broadened (002) diffraction peak of HHA [as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…However, LeGeros et al found that carbonate inclusion in the apatite was accompanied by a systematic a ‐axis parameter decrease and the exclusion of PO 4 3− and concluded that CO 3 2− substituted for PO 4 3− in the precipitated synthetic CAp, resulting in type B CAp. And then it has been widely accepted that there are two types of carbonate substitution in apatite: type A as CO 3 2− for OH ‐ and type B as CO 3 2− for PO 4 3− …”

Section: Introductionmentioning

confidence: 99%

“…It is often referred to as carbonated apatite (CAp). [1][2][3][4] Characterization of CAp can be traced back to the early work of geologist D. McConnell. 5,6 In his microscopic study on geologic thin sections of apatite under polarized light, McConnell observed distinctive optical responses among apatites that released CO 2 when treated with hydrochloric acid (HCl).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Infrared spectroscopic characterization of carbonated apatite: A combined experimental and computational study

Ren

Ding

Leng

2013

J Biomedical Materials Res

107

View full text Add to dashboard Cite

A combined experimental and computational approach was employed to investigate the feasibility and effectiveness of characterizing carbonated apatite (CAp) by infrared (IR) spectroscopy. First, an experimental comparative study was conducted to identify characteristic IR vibrational bands of carbonate substitution in the apatite lattice. The IR spectra of pure hydroxyapatite (HA), carbonate adsorbed on the HA surface, a physical mixture of HA and sodium carbonate monohydrate, a physical mixture of HA and calcite, synthetic CAps prepared using three methods (precipitation method, hydrothermal route, and solid-gas reaction at high temperature) and biological apatites (human enamel, human cortical bone, and two animal bones) were compared. Then, the IR vibrational bands of carbonate in CAp were calculated with density functional theory. The experimental study identified characteristic IR bands of carbonate that cannot be generated from surface adsorption or physical mixtures and the results show that the bands at ∼880, 1413, and 1450 cm(-1) should not be used as characteristic bands of CAp since they could result from carbonate adsorbed on the apatite crystals surface or present as a separate phase. The combined experimental and computational study reveals that the carbonate v3 bands at ∼1546 and 1465 cm(-1) are, respectively, the IR signature bands for type A CAp and type B CAp.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infrared spectroscopic characterization of carbonated apatite: A combined experimental and computational study

Ren

Ding

Leng

2013

J Biomedical Materials Res

107

View full text Add to dashboard Cite

show abstract

“…reactivity. The increase in apatite solubility caused by carbonate incorporation is further increased when Mg 2+ ions were also incorporated [7][8][9]22,23 .…”

Section: Resultsmentioning

confidence: 99%

Simultaneous incorporation of magnesium and carbonate in apatite: effect on physico-chemical properties

et al. 2013

View full text Add to dashboard Cite

Synthetic apatites are widely used both in the dental and the orthopaedic fields due to their similarity in composition with the inorganic phase of hard tissues. Biologic apatites are not pure hydroxyapatite (HA), but are calcium-deficient apatites with magnesium and carbonate as minor but important substituents. The aim of the present study was to produce a more soluble biomaterial through the simultaneous substitution of magnesium and carbonate in the apatite structure to accelerate the degradation time in the body. The physico-chemical and dissolution properties of unsintered magnesium and carbonate-substituted apatite (MCAp) with similar Mg/Ca molar ratio (0.03) and varying C/P molar ratio were evaluated. The resultant powders were characterised using several techniques, such as FTIR, TGA, XRD, ICP and SEM, while the release of calcium ions in a pH 6 solution was monitored using a Ca-ion selective electrode. The results showed a decrease of crystallite size and an increase in the release of calcium to the medium as the carbonate content in the samples increased.

show abstract

“…Conversely, dicalcium phosphate dihydrate [DCPD: CaHPO 4 ·2H 2 O] forming cement or brushite forming cement set to form DCPD on mixing the powder with its liquid phase . In the case of DCPD forming cement, there is no need to worry about flow out.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of self‐setting β‐tricalcium phosphate granular cement

et al. 2017

Self Cite

View full text Add to dashboard Cite

Bone defect reconstruction would be greatly improved if β-tricalcium phosphate (β-TCP) granules had the ability to self-set without sacrificing their osteoconductivity potential. This study aimed to identify a method to permit β-TCP self-setting whilst maintaining good osteoconductivity. When mixed with acidic calcium phosphate solution, β-TCP granules were found to readily set, forming a fully interconnected porous structure. On mixing, dicalcium phosphate dihydrate crystals formed on the surface of β-TCP granules, bridging the granules and resulting in the setting reaction. The setting time of the β-TCP granular cement (β-TCP GC) was approximately 1 min and its mechanical strength, in terms of diametral tensile strength, was approximately 0.8 MPa. The β-TCP GC and β-TCP granules both showed the same level of osteoconductivity within rat calvaria bone defects. At 2 and 4 weeks post-implantation, new bone formation was comparable between the two β-TCP based bone substitutes. We conclude that β-TCP GC has excellent potential for use as a cement in bone defect reconstruction. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 800-807, 2018.

show abstract

Fundamentals of Hydroxyapatite and Related Calcium Phosphates

Cited by 65 publications

References 83 publications

Infrared spectroscopic characterization of carbonated apatite: A combined experimental and computational study

Infrared spectroscopic characterization of carbonated apatite: A combined experimental and computational study

Simultaneous incorporation of magnesium and carbonate in apatite: effect on physico-chemical properties

Fabrication of self‐setting β‐tricalcium phosphate granular cement

Contact Info

Product

Resources

About