Fundamentals and recent progress relating to the fabrication, functionalization and characterization of mesostructured materials using diverse synthetic methodologies

Soltani, Soroush; Khanian, Nasrin; Rashid, Umer; Choong, Thomas Shean Yaw

doi:10.1039/d0ra00440e

Cited by 22 publications

(10 citation statements)

References 152 publications

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“… 43 To this end, we will also study the further functionalization of these silica nanodiscs to equip them with additional properties. 44 Generating silica-stabilized membrane proteins or cell-based reactors has been attempted for several decades by coating cells with silica either by the direct addition of silica particles 45 or by employing charged polymers in combination with silicic acid. 46 Our approach, however, provides well-defined membrane discs, and their diameter can be adapted by using different MSP constructs as well as different lipid compositions.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase

Bialas

Becker

2021

Bioconjugate Chem.

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Integral membrane proteins (IMPs) comprise highly important classes of proteins such as transporters, sensors, and channels, but their investigation and biotechnological application are complicated by the difficulty to stabilize them in solution. We set out to develop a biomimetic procedure to encapsulate functional integral membrane proteins in silica to facilitate their handling under otherwise detrimental conditions and thereby extend their applicability. To this end, we designed and expressed new fusion constructs of the membrane scaffold protein MSP with silica-precipitating peptides based on the R5 sequence from the diatom Cylindrotheca fusiformis . Transmission electron microscopy (TEM) and atomic force microscopy (AFM) revealed that membrane lipid nanodiscs surrounded by our MSP variants fused to an R5 peptide, so-called nanodiscs, were formed. Exposing them to silicic acid led to silica-encapsulated nanodiscs, a new material for stabilizing membrane structures and a first step toward incorporating membrane proteins in such structures. In an alternative approach, four fusion constructs based on the amphiphilic β-sheet peptide BP-1 and the R5 peptide were generated and successfully employed toward silica encapsulation of functional diacylglycerol kinase (DGK). Silica-encapsulated DGK was significantly more stable against protease exposure and incubation with simulated gastric fluid (SGF) and intestinal fluid (SIF).

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Section: Discussionmentioning

confidence: 99%

Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase

Bialas

Becker

2021

Bioconjugate Chem.

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“…Although the synthesis and grafting of mesostructured SiO2 materials is by far the best documented in literature 14,15 , non-siliceous mesoporous transition metal oxides (e.g. TiO2, ZrO2, Al2O3, ZnO, ITO) are gaining interest as well as their use in a wide variety of solvents and pH ranges.…”

Section: Introductionmentioning

confidence: 99%

Experimental and computational insights into the aminopropylphosphonic acid modification of mesoporous TiO2 powder: The role of the amine functionality on the surface interaction and coordination

Gys

Siemons

Pawlak

et al. 2021

Applied Surface Science

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Recently, interest has been directed towards the grafting of metal oxides with organophosphonic acids bearing terminal amine groups to extend the functionality and applicability of these materials. Previous reports mainly focus on the application perspective, while a detailed characterization of the surface properties at the molecular level and the correlation with the synthesis conditions are missing. In this work, mesoporous TiO2 powder is grafted with 3-aminopropylphosphonic acid (3APPA) under different concentrations (20, 75, 150 mM) and temperatures (50, 90 °C) and compared with propylphosphonic acid (3PPA) grafting to unambiguously reveal the impact of the amine group on the surface properties. A combination of complementary spectroscopic techniques and Density Functional Theory -Periodic Boundary Conditions (DFT/PBC) calculations are used. At 90 °C and high concentrations, lower modification degrees are obtained for 3APPA compared to Revised manuscript (unmarked) ick ere t vie inked Re erences 2 3PPA, due to amine-induced surface interactions. Both X-ray Photoelectron Spectroscopy (XPS) and Diffuse Reflectance Infrared Fourier Transform (DRIFT) spectroscopy reveal that both NH2 and NH3 + groups are present, with also contributions of NH2 groups involved in hydrogen bonding interactions. A similar ratio of NH2/NH3 + (65:35) is obtained irrespective of the modification conditions, suggesting similar relative contributions of different surface conformations. Calculated adsorption energies from DFT calculations on 3APPA adsorption on anatase (101) in relation to the water coverage reveals a coexistence of various structures with the amine group involved in intra-adsorbate, inter-adsorbate and adsorbate-surface interactions. Further validation is obtained from the strong overlap of different 31 P environments represented by the broad band (35-12 ppm) in experimental 31 P Nuclear Magnetic Resonance (NMR) spectra and calculated 31 P chemical shifts of all modelled monodentate and bidentate structures. Structures related to the tridentate binding mode are not formed due to geometric restrictions of the anatase (101) facet applied as model support in the calculations. Nevertheless, they could be present in the experimental samples as they are composed of anatase (representing multiple crystal facets) and an amorphous titania fraction.

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“…However, this technique is quite complicated and expensive to implement. Moreover, the obtained mesoporous materials, despite the unique characteristics, have some disadvantages such as insufficient thermal stability of the structure, powdered instead of granular state [19]. Post-synthetic modification of precipitated oxides, hydroxides and phosphates is a simpler, cheaper, however an effective method for regulating the parameters of their porous structure.…”

Section: Introductionmentioning

confidence: 99%

Influence of hydrothermal, microwave and mechanochemical treatment of tin phosphate on porous structure and catalytic properties

Sydorchuk¹,

Khalameida²,

Charmas

et al. 2021

J Sol-Gel Sci Technol

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Micro-mesoporous tin phosphate is prepared via precipitation under acid medium with subsequent modification using hydrothermal, microwave, and mechanochemical treatments (HTT, MWT, and MChT, respectively). The structure of the initial and modified samples is studied using nitrogen adsorption-desorption, DTA-TG and XRD analysis, FTIR spectroscopy, and SEM. Selected samples are tested as catalysts in aldol condensation of formaldehyde with acetic acid and in photocatalytic degradation of safranin T under visible irradiation. It is established that modification, primarily under hydrothermal conditions, results in the formation of mesoporous or meso-macroporous structure which is more accessible for the reagents molecules and more resistant to sintering and coking at higher temperature. Maximum effect is obtained in the case of modification of wet gel. Catalytic performance of the tested samples in aldol condensation is primarily determined by the parameters of their porous structure. The acquisition of photocatalytic activity is due to the narrowing of the band gap as a result of modification.

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Fundamentals and recent progress relating to the fabrication, functionalization and characterization of mesostructured materials using diverse synthetic methodologies

Abstract: Since 1990 and the invention of the very first generation of ordered mesoporous silica materials, several innovative methodologies have been applied to synthesize, characterize, and modify silica/non-silica mesoporous materials.

Cited by 22 publications

References 152 publications

Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase

Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase

Experimental and computational insights into the aminopropylphosphonic acid modification of mesoporous TiO2 powder: The role of the amine functionality on the surface interaction and coordination

Influence of hydrothermal, microwave and mechanochemical treatment of tin phosphate on porous structure and catalytic properties

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