Fundamental understanding of the size and surface modification effects on r₁, the relaxivity of Prussian blue nanocube@m-SiO₂: a novel targeted chemo-photodynamic theranostic agent to treat colon cancer

Abstract

A targeted multimodal strategy on a single nanoplatform is attractive in the field of nanotheranostics for the complete ablation of cancer.

Quercetin@Gd3+ doped Prussian blue nanocubes induce the pyroptotic death of MDA-MB-231 cells: combinational targeted multimodal therapy, dual modal MRI, intuitive modelling of r1–r2 relaxivities

“…Herein, it may be stated that T IS 1M consists of two different interactions, namely scalar (T SC 1 ) and dipole-dipole (T DD 1 ), ascribed to electronic and nuclear interactions between H 2 O protons and as-synthesized nanocubes, but we found that T 1M c T DD 1 , whereas the Curie spin relaxation mechanism dominates T 2M . 16,49 Moreover, it was reported earlier that the electronic relaxation time (t e ) is inconsiderable at a high magnetic field (B3 T) and t m c t R , which indicates t ci , t cs E t R , where t ci (i = 1, 2) and t cs denote magnetic fluctuation time and Curie spin correlation time. 16,50 Herein, t R , t ci (i = 1, 2) and t cs denote rotational correlation time, magnetic fluctuation time and Curie spin correlation time.…”

“…16,49 Moreover, it was reported earlier that the electronic relaxation time (t e ) is inconsiderable at a high magnetic field (B3 T) and t m c t R , which indicates t ci , t cs E t R , where t ci (i = 1, 2) and t cs denote magnetic fluctuation time and Curie spin correlation time. 16,50 Herein, t R , t ci (i = 1, 2) and t cs denote rotational correlation time, magnetic fluctuation time and Curie spin correlation time. Based on these approximations, r IS 1 and r IS 2 can be further simplified as follows:…”

“…Previously, we have examined multimodal theranostic efficiencies revealing good potency of PBNC in cancer therapy as well as in diagnosis with r 1 relaxivity of B5.14 mM À1 s À1 . 16 We know that linear (DTPA-type) or macrocyclic (DOTA-type) Gd 3+ complexes are approved contrast agents for MRI, wherein Gd 3+ plays a significant role. 19 Herein, we report on the design and synthesis and evaluation of r 1 -r 2 relaxivities, PTT and PDT effects of Gd 3+ -doped PBNC (GPBNC), wherein the results yield a significant increase in relaxometric parameters benefiting MRI diagnosis and finally the theranostic activities of Qu-encapsulated optimized GPBNC have been tested against TNBC.…”

“…In addition, it has also been noted from previous literature reports, including some by us, that PBNC can be an important contrast agent for magnetic resonance imaging (MRI), which is one of the most commonly adopted noninvasive clinical techniques to diagnose TNBC anatomically. 16 As MRI signals depend significantly on different specialities or features of the cancer cells, a contrast agent is widely employed to visualize the internal structure of TNBC. In general, contrast agents are classified into positive ( T 1 ) contrast agents that lead to the lesion looking bright, and negative ( T 2 ) contrast agents that make the lesion dark.…”

Long Circulating Cancer Cell-Targeted Bionic Nanocarriers Enable Synergistic Combinatorial Therapy in Colon Cancer

“…In this study, we developed erythrocyte and HCT116 cancer cell hybrid membrane-cloaked ROS-responsive nanoparticles to obtain a biomimetic nanocarrier co-encapsulating oxaliplatin (Oxa) and chlorin e6 (Ce6) (denoted as hNPOC) for chemophotodynamic synergistic therapy of colon cancer. − As shown in Figure , the RBC membrane (rM) and cancer cM were separately obtained from respective erythrocytes and HCT116 cells and then fused together to form an RBC-HCT116 hybrid membrane. The nanoparticle cargo was fabricated by utilizing a reactive oxygen species (ROS)-responsive polyphosphoester (Figure S1, TK-PPE, containing extensive thioketal bond) to co-encapsulate Oxa and Ce6 (denoted as NPOC) according to the nanoprecipitation method.…”