Fundamental study for development magnetic drug delivery system

Hirota, Yutaka; Akiyama, Yoko; Izumi, Yoshinobu; Nishijima, Shigehiro

doi:10.1016/j.physc.2009.05.248

Cited by 33 publications

(22 citation statements)

References 2 publications

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“…The applicability of the MDDS has been studied [1], [2], and we also have confirmed that the magnetite particles were accumulated in rat liver by using the small permanent magnet [3]. Manuscript However, in case of the accumulation with small permanent magnet, it is difficult to accumulate the ferromagnetic particle in the small area away from the magnet.…”

supporting

confidence: 57%

Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets

Hirota

Mishima

Akiyama

et al. 2010

IEEE Trans. Appl. Supercond.

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Side-effects and lowering effects by diffusion of drugs such as anticancer agents is one of the serious issues in medication. To solve the problem, it is necessary to control the drugs quantitatively, spatially and temporally within the human body. Magnetic drug delivery system (MDDS) is one of the technologies that would make it possible, in which the ferromagnetic drug injected into the blood vessel is conducted to diseased part by external magnetic force. The ultimate goal of our study is to develop MDDS which can be used to guide the drug to the diseased part by controlling its movements from outside of human body using superconducting bulk magnet and ferromagnetic needle, and fundamental experiments to establish the MDDS system was conducted. To estimate the magnetic force required to accumulate ferromagnetic particle in blood vessel, particle distribution in the limited biomedical tissue was calculated. To check the validity of calculation, accumulation experiment of ferromagnetic particle in a model tissue consisting of glass beads packed in a glass tube was conducted. Based on these results, design of MDDS using permanent magnet system with facing two poles in a glass tube was conducted.Index Terms-Drug delivery, ferromagnetic needle, local accumulation, magnet system with facing two poles.

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supporting

confidence: 57%

Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets

Hirota

Mishima

Akiyama

et al. 2010

IEEE Trans. Appl. Supercond.

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“…It also has been used in biomedicine as a magnetic drug delivery system (MDDS) [8][9][10], as a contrast agent for magnetic resonance imaging (MRI) [11,12] and as heating mediator for cancer thermotherapy [13,14]. Magnetite remains as the only magnetic nanoparticle (MNP) approved for clinical use to date [15] because it features low toxicity effects in cells [16].…”

Section: Introductionmentioning

confidence: 99%

Influence of stirring velocity on the synthesis of magnetite nanoparticles (Fe3O4) by the co-precipitation method

Valenzuela

Fuentes

Parra

et al. 2009

Journal of Alloys and Compounds

152

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“…Drug or protein is associated with the magnetic NSs by functional groups, injected to circulatory system, and transported towards the problem area by magnetic field. Perspectives of this method have been shown in modeling studies [5,6] and tests on animals [7,8], but results of clinical tests have not been reported yet. It indicates that some difficulties are in the targeted delivery.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

Kozlovskiy

Korolkov

Kalkabay

et al. 2017

Journal of Nanomaterials

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Due to the Ni nanotubes' shape anisotropy, low specific density, large specific surface, and uniform magnetic field, they have been offered as carriers for targeted delivery of drug or protein and the process of their formation from synthesis stage to the stage of surface modification and protein attaching has been demonstrated. Some steps to hasten their biomedical application have been applied. First, to have full control over the carrier dimensions and structure parameters, electrodeposition method in pores of polyethylene terephthalate template has been applied. Second, to understand the scope of Ni nanostructures application, their degradation in media with different acidity has been studied. Third, to improve the biocompatibility and to make payloads attachment possible, nanotubes surface modification with organosilicon compound has been carried out. At last, the scheme of protein attaching to the nanostructure surface has been developed and the binding process was demonstrated as an example of the bovine serum albumin.

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Fundamental study for development magnetic drug delivery system

Cited by 33 publications

References 2 publications

Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets

Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets

Influence of stirring velocity on the synthesis of magnetite nanoparticles (Fe3O4) by the co-precipitation method

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

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