Fundamental research progress of mild hypothermia in cerebral protection

Bao, Lei; Xu, Feng

doi:10.1186/2193-1801-2-306

Cited by 11 publications

(3 citation statements)

References 86 publications

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“…Moreover, although both HI normothermic and HI hypothermic males and females sustained significant damage to grey matter (cortex, hippocampus), hypothermic animals had significantly less grey matter damage than normothermic subjects—again affirming the translational potential of neuroprotection via hypothermia in preterm infants (Figures 1 and 2 ). These findings are consistent with general models of hypothermia as a mechanism to slow apoptosis and prevent cell death [ 19 , 46 , 47 ].…”

Section: Discussionsupporting

confidence: 89%

Effects of Sex and Mild Intrainsult Hypothermia on Neuropathology and Neural Reorganization following Neonatal Hypoxic Ischemic Brain Injury in Rats

2016

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Hypoxia ischemia (HI) is a recognized risk factor among late-preterm infants, with HI events leading to varied neuropathology and cognitive/behavioral deficits. Studies suggest a sex difference in the incidence of HI and in the severity of subsequent behavioral deficits (with better outcomes in females). Mechanisms of a female advantage remain unknown but could involve sex-specific patterns of compensation to injury. Neuroprotective hypothermia is also used to ameliorate HI damage and attenuate behavioral deficits. Though currently prescribed only for HI in term infants, cooling has potential intrainsult applications to high-risk late-preterm infants as well. To address this important clinical issue, we conducted a study using male and female rats with a postnatal (P) day 7 HI injury induced under normothermic and hypothermic conditions. The current study reports patterns of neuropathology evident in postmortem tissue. Results showed a potent benefit of intrainsult hypothermia that was comparable for both sexes. Findings also show surprisingly different patterns of compensation in the contralateral hemisphere, with increases in hippocampal thickness in HI females contrasting reduced thickness in HI males. Findings provide a framework for future research to compare and contrast mechanisms of neuroprotection and postinjury plasticity in both sexes following a late-preterm HI insult.

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Section: Discussionsupporting

confidence: 89%

Effects of Sex and Mild Intrainsult Hypothermia on Neuropathology and Neural Reorganization following Neonatal Hypoxic Ischemic Brain Injury in Rats

2016

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“…[ 64 ] However, hypothermia is associated with increased incidence of coagulopathy, cardiac dysrhythmias, wound infection, and need for postoperative ventilation. [ 65 ] Even mild levels of hypothermia are not without potential risk. Passive rewarming is associated with peripheral vasoconstriction, shivering, and subsequent increases in oxygen consumption and myocardial work.…”

Section: Intraoperative Considerationsmentioning

confidence: 99%

Principles of neuroanesthesia in aneurysmal subarachnoid hemorrhage

Kundra

Mahendru

Gupta

et al. 2014

J Anaesthesiol Clin Pharmacol

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Aneurysmal subarachnoid hemorrhage is associated with high mortality. Understanding of the underlying pathophysiology is important as early intervention can improve outcome. Increasing age, altered sensorium and poor Hunt and Hess grade are independent predictors of adverse outcome. Early operative interventions imposes an onus on anesthesiologists to provide brain relaxation. Coiling and clipping are the two treatment options with increasing trends toward coiling. Intraoperatively, tight control of blood pressure and adequate brain relaxation is desirable, so that accidental aneurysm rupture can be averted. Patients with poor grades tolerate higher blood pressures, but are prone to ischemia whereas patients with lower grades tolerate lower blood pressure, but are prone to aneurysm rupture if blood pressure increases. Patients with Hunt and Hess Grade I or II with uneventful intraoperative course are extubated in operation theater, whereas, higher grades are kept electively ventilated. Postoperative management includes attention toward fluid status and early management of vasospasm.

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“…5,6 In neuroinflammation and cerebral ischemia, particularly reperfusion, NF-κB translocation into the core and ischemic penumbra, as well as into the microvessels of the affected region. 6,7 NF-κB is a key regulator of innate immunity, inflammation and of cell survival and proliferation. 8 This inducible transcription factor is comprised of two subunits.…”

Section: Introductionmentioning

confidence: 99%

Impact of novel N-aryl piperamide NO donors on NF-κB translocation in neuroinflammation: rational drug-designing synthesis and biological evaluation

et al. 2017

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NO donor drugs showed a significant therapeutic effect in the treatment of many diseases, such as arteriopathies, various acute and chronic inflammatory conditions, and several degenerative diseases. NO-releasing anti-inflammatory drugs are the prototypes of a novel class of compounds, combining the pharmacological activities of anti-inflammatory and anti-nociceptive of drugs with those of NO, thus possessing potential therapeutic applications in a great variety of diseases. In this study, we designed and predicted biological activity by targeting cyclooxygenase type 2 (COX-2) and NFkB subunits and pharmacological profiling along with toxicity predictions of various N-aryl piperamides linked via an ester bond to a spacer that is bound to a NO-releasing moiety (-ONO2). The result of absorption, distribution, metabolism and excretion and Docking studies indicated that among 51 designed molecules PA-3 0 K showed the best binding potential in both the substrate and inhibitory binding pocket of the COX-2 enzyme with affinity values of -9.33 and -5.12 for PDB ID 1CVU and 3LN1, respectively, thereby having the potential to be developed as a therapeutic agent. The results of cell viabilities indicated that PA-3 0 k possesses the best cell viability property with respect to its dose (17.33 ng/ml), with 67.76% and 67.93% viable cells for CHME3 and SVG cell lines, respectively.

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Fundamental research progress of mild hypothermia in cerebral protection

Cited by 11 publications

References 86 publications

Effects of Sex and Mild Intrainsult Hypothermia on Neuropathology and Neural Reorganization following Neonatal Hypoxic Ischemic Brain Injury in Rats

Effects of Sex and Mild Intrainsult Hypothermia on Neuropathology and Neural Reorganization following Neonatal Hypoxic Ischemic Brain Injury in Rats

Principles of neuroanesthesia in aneurysmal subarachnoid hemorrhage

Impact of novel N-aryl piperamide NO donors on NF-κB translocation in neuroinflammation: rational drug-designing synthesis and biological evaluation

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