Fundamental gap in fundamental biology

Abstract

The article raises the problems of intracellular spatial and temporal organization of metabolism, signaling, and energy supply of these processes. To provide cell functions, the enzymes of metabolic chains, molecules of signaling pathways, and macroergs (as units of molecular interactions, accompanied by energy consumption) should find their partners and get their precise spatial relationship. The current views are based on ideas of compartmentalization of all processes as local sites of cellular matrix membrane, where specific stages of different metabolic cycles take place. The assembly of complexes of macromolecules in the number and combinations, required for their adequate functioning in the space of a cell, is generally described as intracellular transport of vesicles, implemented by mobile elements of cytoske-leton. Inside the vesicle there is «effective load»-macromolecules. The membranes of these vesicles fuse with specific sites of the matrix membranes and therefore relocate macromolecules. Neither calculations nor assumptions allow explaining precise formation of enzymatic chains, their interaction, signaling, etc. on this basis. Such transport of macromolecules (inside vesicles) enables solving other tasks. The concept of search-and-address systems in the form of space-scanning micro vesicles is proposed and well-grounded for purposes of searching for partners, forming chains and complexes, and building compartments. The micro vesicles collect corresponding chains of enzymes, signaling, and ensure the interactions on their surface. These micro vesicles are exactly those compartments, which provide for both precision of processes and their relationship.

Umbilical Cord Tissue-Derived Cells as Therapeutic Agents

“…The more characteristics that can be evaluated and fully described, the more features there are to analyse: here is their vector. And as there are more and more new findings and characteristics every year, presumably this analytical process could be virtually endless [ 118 ]. For example, another one-gene screening of WJ-MSCs has been performed by Mechiche Alami et al [ 119 ].…”

40 years within two epochs of two millennia

“…These were followed by a generalizing monograph -«Our «Shagreen leather» is our problem. We have to solve it ourselves» [34]. Later these ideas were experimentally developed and theoreti-cally improved [35][36][37].…”

Untitled

“…These were followed by a generalizing monograph -«Our «Shagreen leather» is our problem. We have to solve it ourselves» [34]. Later these ideas were experimentally developed and theoreti-cally improved [35][36][37].…”