Fundamental Factors Governing Lymphatic Spread of Carcinoma

Gilchrist, R. K.

doi:10.1097/00000658-194004000-00014

Cited by 38 publications

(8 citation statements)

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“…Thus when cancer cells are injected into the efferent lymphatic vessels of popliteal nodes in rabbits, passage of the cells through the nodes is delayed for about six weeks, by which time the nodes have been destroyed by growth (Zeidman and Buss, 1954). Filtration of tumour emboli at lymph nodes has also been postulated by Gilchrist (1940) and by Willis (1952) from studies of the human pathology of cancer of the rectum and lung respectively. In coal-miners' lungs, much inhaled dust is taken into the lymphatics by phagocytes and deposited in the regional lymph nodes.…”

Section: Discussionmentioning

confidence: 71%

Prognosis of Coal-miners with Cancer of the Lung

Goldman¹

1965

Thorax

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Section: Discussionmentioning

confidence: 71%

Prognosis of Coal-miners with Cancer of the Lung

Goldman¹

1965

Thorax

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“…Lymphatic spread of metastatic carcinoma was defined by the work of Gilchrist [18] and Zeidman [19] et al in the mid-twentieth century. Their studies involved injecting various dyes, carbonaceous particles and cancer cells into the lymphatics of animal models.…”

Section: Historymentioning

confidence: 99%

The Application and Indications for Sentinel Lymph Node Biopsy in Pediatric Solid Tumors: Current Status and Future Directions

Hinkle¹,

Malkan²,

Sandoval

2014

IJCM

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Oncologic staging of many solid organ malignancies involves an understanding of how cancers spread via the lymphatic system, and ultimately may involve evaluation of the primary nodal drainage basin by performing a sentinel lymph node biopsy. In the adult population, there are well established indications for sentinel lymph node biopsy in diseases like melanoma and breast cancer. However, its use and relevance in the pediatric population is less defined. This review details the history and development of sentinel lymph node biopsy technique, advanced lymph node mapping techniques currently under investigation, and the applications of sentinel node biopsy towards childhood cancers.

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“…Studying mesenteries of dogs and rabbits, Gilchrist saw no passage of carbon suspensions through any node after injections with varying pressures [2]. Zeidman and Buss injected stained V 2 carcinoma cells into the afferent lymphatics of popliteal nodes in rabbits [3].…”

Section: Dissemination Theoriesmentioning

confidence: 99%

History of sentinel node and validation of the technique

et al. 2001

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Sentinel node biopsy is a minimally invasive technique to select patients with occult lymph node metastases who may benefit from further regional or systemic therapy. The sentinel node is the first lymph node reached by metastasising cells from a primary tumour. Attempts to remove this node with a procedure based on standard anatomical patterns did not become popular. The development of the dynamic technique of intraoperative lymphatic mapping in the 1990s resulted in general acceptance of the sentinel node concept. This hypothesis of sequential tumour dissemination seems to be valid according to numerous studies of sentinel node biopsy with confirmatory regional lymph node dissection. This report describes the history and the validation of the technique, with particular reference to breast cancer.

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Fundamental Factors Governing Lymphatic Spread of Carcinoma

Cited by 38 publications

References 0 publications

Prognosis of Coal-miners with Cancer of the Lung

Prognosis of Coal-miners with Cancer of the Lung

The Application and Indications for Sentinel Lymph Node Biopsy in Pediatric Solid Tumors: Current Status and Future Directions

History of sentinel node and validation of the technique

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