Fundamental challenges and opportunities for preparative supercritical fluid chromatography

Guiochon, Georges; Tarafder, Abhijit

doi:10.1016/j.chroma.2010.12.047

Cited by 198 publications

(96 citation statements)

References 421 publications

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“…Column equilibration is also faster, allowing for short cycle times in gradient analysis. The backpressures generated are lower compared to liquid phases, while providing the solvating power similar to that of a liquid, allowing for good solubility and fast transport of the analytes (Guiochon and Tarafder, 2011).…”

Section: Chapter 12 Ultra-high Performance Supercritical Fluidmentioning

confidence: 99%

“…Furthermore, there are many intermediate states, such as a high-density liquid, high-temperature gas, etc. A wide range of states with intermediate densities (from gas-like to liquid-like density) can thus be reached without the formation of an interface and may be changed by adjusting the temperature and/or the pressure (Guiochon and Tarafder, 2011).…”

Section: Supercritical Fluidsmentioning

confidence: 99%

“…Further modifications are needed in the autosampler and detector modules. The software to control an SFC instrument is also identical to that used in HPLC, except an additional control variable, column outlet pressure, is used (Berger, 2015a;Saito, 2013;Guiochon and Tarafder, 2011).…”

Section: Supercritical Fluid Chromatography 453mentioning

confidence: 99%

“…Phase separation almost never occurs if the pressure remains high enough (Saito, 2013;Maftouh et al, 2005;Berger, 1997). The physical characteristics of CO 2 , and the binary mixtures with organic modifiers, are addressed in more detail in recently published papers Guiochon and Tarafder, 2011). …”

Section: Introduction 447mentioning

confidence: 99%

“…During the development of SFC over the years, the technique was given many other names, such as: high temperatureehigh pressure chromatography; dense GC; high pressure gas chromatography (HPGC); solvating gas chromatography; subcritical fluid chromatography; near critical chromatography; convergence chromatography; enhanced fluidity chromatography; HPLC with enhanced fluidity or sometimes even unified chromatography Guiochon and Tarafder, 2011;Taylor, 2009). In the most modern interpretations, the name could also be translated as separations facilitated by carbon dioxide.…”

Section: Introductionmentioning

confidence: 99%

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Section: Chapter 12 Ultra-high Performance Supercritical Fluidmentioning

confidence: 99%

Section: Supercritical Fluidsmentioning

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Section: Supercritical Fluid Chromatography 453mentioning

confidence: 99%

Section: Introduction 447mentioning

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Supercritical Fluid Chromatography

Yuan¹,

Olesik²,

West³

2019

Encyclopedia of Analytical Chemistry

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Supercritical fluid chromatography (SFC) employs fluids that are raised above their critical pressure ( P c ) and critical temperature ( T c ) as mobile phases. Carbon dioxide is the fluid most commonly used as a mobile phase for SFC. It is capable of solvating nonpolar and moderately polar analytes. Cosolvents and additives are combined to CO 2 to increase the polarity range of analytes. SFC has a wide versatility in terms of retention mechanisms as all stationary phases employed in normal‐phase or reversed‐phase chromatography can be used. The advantages of SFC over liquid chromatography (LC) include higher efficiency separations and faster speed of analysis and method development. The advantage of SFC over gas chromatography (GC) is that SFC can efficiently separate thermally labile and nonvolatile compounds without the need for derivatization. Capillary SFC is commonly used to separate petroleum distillates and by‐products. The most employed packed‐column SFC is mostly used to analyze achiral and chiral pharmaceuticals, natural products, food products, agrochemicals, and other contaminants in food products or in the environment, and more recently for the analysis of biological samples (lipidomics, metabolomics, and pharmacokinetic studies for instance). Preparative packed column supercritical fluid chromatography (pSFC) is principally employed not only for the purification of pharmaceuticals but also for natural products.

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Recent Developments in Automated Solution Phase Library Production

Maier

Czechtizky

2015

Small Molecule Medicinal Chemistry

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Fundamental challenges and opportunities for preparative supercritical fluid chromatography

Cited by 198 publications

References 421 publications

Theory and Practice of UHPLC and UHPLC–MS

Theory and Practice of UHPLC and UHPLC–MS

Supercritical Fluid Chromatography

Recent Developments in Automated Solution Phase Library Production

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