Functions of RNA-Binding Proteins in Cardiovascular Disease

Ruffenach, Grégoire; Medzikovic, Lejla; Sun, Wasila; Hong, Jason; Eghbali, Mansoureh

doi:10.3390/cells12242794

Cited by 3 publications

(2 citation statements)

References 92 publications

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“…Loss or the dysregulated activity of several RBPs have been closely associated with cardiomyopathies in humans or in animal models, as exemplified by RBM20 mutations in DCM patients [ 13 ]. With the expanded identification of the cardiac-specific RBPome, the contribution of RBP-mediated post-transcriptional regulation of cardiac-specific gene expression networks has gained considerable interest for better understanding the complexity of heart development and function [ 22 , 23 , 24 , 25 , 26 ]. Importantly, correcting pathogenic mutations in RBPs or manipulating their activity has the strong potential to rescue cardiomyopathy or promote cardiac regeneration after myocardial injury [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

RNA-Binding Proteins in Cardiomyopathies

Shi

2024

JCDD

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The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction. Dysfunctions of RNA-binding proteins impair heart development and cause the main types of cardiomyopathies, which represent a heterogenous group of abnormalities that severely affect heart structure and function. In particular, mutations of RBM20 and RBFOX2 are associated with dilated cardiomyopathy, hypertrophic cardiomyopathy, or hypoplastic left heart syndrome. Functional analyses in different animal models also suggest possible roles for other RNA-binding proteins in cardiomyopathies because of their involvement in organizing cardiac gene programming. Recent studies have provided significant insights into the causal relationship between RNA-binding proteins and cardiovascular diseases. They also show the potential of correcting pathogenic mutations in RNA-binding proteins to rescue cardiomyopathy or promote cardiac regeneration. Therefore, RNA-binding proteins have emerged as promising targets for therapeutic interventions for cardiovascular dysfunction. The challenge remains to decipher how they coordinately regulate the temporal and spatial expression of target genes to ensure heart function and homeostasis. This review discusses recent advances in understanding the implications of several well-characterized RNA-binding proteins in cardiomyopathies, with the aim of identifying research gaps to promote further investigation in this field.

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Section: Introductionmentioning

confidence: 99%

RNA-Binding Proteins in Cardiomyopathies

Shi

2024

JCDD

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“…An increase in HuR expression in mouse cardiomyocytes has been observed during ischemia and reperfusion injury, where it has been shown to stabilize beclin mRNA, which leads to increased cell death. 7 Therefore, the role of HuR in cardiomyocyte and endothelial cell function in the context of cardiac fibrosis requires further investigation. Also, inflammation and cardiac tissue injury are closely associated, and previous studies have reported that HuR can up-regulate the expression of proinflammatory cytokines, including tumor necrosis factor α, 8 and increase the recruitment of macrophages in the injured heart.…”

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Human Antigen R, a Myofibroblast-Specific Target in Treating Cardiac Fibrosis

Srivastava,

Dhingra

2024

JACC: Basic to Translational Science

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The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

Lin,

Chu,

et al. 2024

Biomolecules

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RNA-binding proteins (RBPs) have pivotal roles in cardiovascular biology, influencing various molecular mechanisms underlying cardiovascular diseases (CVDs). This review explores the significant roles of RBPs, focusing on their regulation of RNA alternative splicing, polyadenylation, and RNA editing, and their impact on CVD pathogenesis. For instance, RBPs are crucial in myocardial injury, contributing to disease progression and repair mechanisms. This review systematically analyzes the roles of RBPs in myocardial injury, arrhythmias, myocardial infarction, and heart failure, revealing intricate interactions that influence disease outcomes. Furthermore, the potential of RBPs as therapeutic targets for cardiovascular dysfunction is explored, highlighting the advances in drug development and clinical research. This review also discusses the emerging role of RBPs as biomarkers for cardiovascular diseases, offering insights into their diagnostic and prognostic potential. Despite significant progress, current research faces several limitations, which are critically examined. Finally, this review identifies the major challenges and outlines future research directions to advance the understanding and application of RBPs in cardiovascular medicine.

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Functions of RNA-Binding Proteins in Cardiovascular Disease

Cited by 3 publications

References 92 publications

RNA-Binding Proteins in Cardiomyopathies

RNA-Binding Proteins in Cardiomyopathies

Human Antigen R, a Myofibroblast-Specific Target in Treating Cardiac Fibrosis

The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

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