Functions of long non-coding RNA ROR in patient-derived glioblastoma cells

LncBIRC3-OT promotes the malignant progression of glioma by interacting with RELA to upregulate stanniocalcin-1 expression

“…In recent years, increasing evidence revealed that dysregulation of several lncRNAs is closely associated with glioma development, progression, and treatment resistance [ [26] , [27] , [28] ]. For example, lncRNA LINREP linc-RoR has been identified as a pro-oncogenic molecule and promotes glioma progression [ 11 , 29 ]. Moreover, several lncRNAs including LINC00520, XLOC013218, and PDIA3P1, contribute to the acquisition of temozolomide resistance [ 10 , 30 , 31 ].…”

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

“…As a result, a signature of such lncRNAs with highest dysregulation can be developed for predicting the response of GBM to therapy and also, application of prognostic factor. The lncRNAs HOTAIR, MALAT1, H19 and LINC-ROR [ 220 ] have been shown to regulate the survival rate and therefore, they can be utilized as prognostic and diagnostic factors in GBM. The studies have demonstrated that changes in the expression levels HOTAIR and SAMMSON are significant among others and their high levels can change the prognosis and survival rate of patients.…”

Influence of the Cultivation Conditions of the Glioblastoma Neurosphere on the Expression of MALAT1 and LINCROR Long Non-coding RNA Genes

“…This transcript serves as a positive regulator of expression of the so-called stemness genes ( SOX2 , OCT4 , and NANOG ) and has oncogenic functions in many cancers [ 5 , 6 ]. Previously, our laboratory showed that lincROR increases the level of a key glioblastoma CSCs marker, CD133 [ 7 ], which serves not only as one of the surface markers of CSCs, but is also involved in the pathogenesis of GBM [ 8 ]. Another lncRNA influencing the level of the mentioned marker is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1).…”