Functions of Blood Group Antigens

Stamler, Jonathan S.; Telen, Marilyn J.

doi:10.1002/9781444318531.ch22

Cited by 2 publications

(2 citation statements)

References 114 publications

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“…Group AB consists of antigen A plus antigen B, which is made of galactose on the H chain [ 50 ]. The role of these antigens is obvious in serology and transfusion; however, there are researchers concerned with a link between susceptibility to some diseases, such as malaria or hereditary spherocytosis, and certain blood groups, e.g., the ABO antigens with transmembrane proteins that comprise transporters [ 51 , 52 , 53 , 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

An Insight into the Stages of Ion Leakage during Red Blood Cell Storage

Zimna

Kaczmarska

Szczęsny-Małysiak

et al. 2021

IJMS

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Packed red blood cells (pRBCs), the most commonly transfused blood product, are exposed to environmental disruptions during storage in blood banks. In this study, temporal sequence of changes in the ion exchange in pRBCs. Standard techniques commonly used in electrolyte measurements were implemented. The relationship between ion exchange and red blood cells (RBCs) morphology was assessed with use of atomic force microscopy with reference to morphological parameters. Variations observed in the Na+, K+, Cl−, H+, HCO3−, and lactate ions concentration show a complete picture of singly-charged ion changes in pRBCs during storage. Correlation between the rate of ion changes and blood group type, regarding the limitations of our research, suggested, that group 0 is the most sensitive to the time-dependent ionic changes. Additionally, the impact of irreversible changes in ion exchange on the RBCs membrane was observed in nanoscale. Results demonstrate that the level of ion leakage that leads to destructive alterations in biochemical and morphological properties of pRBCs depend on the storage timepoint.

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Section: Resultsmentioning

confidence: 99%

An Insight into the Stages of Ion Leakage during Red Blood Cell Storage

Zimna

Kaczmarska

Szczęsny-Małysiak

et al. 2021

IJMS

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“…Thus, the presence of coral Rh-like proteins in the symbiosome membrane cannot be taken for granted. Finally, some mammalian Rhs may transport both NH3 and NH4 + (20) and others have structural functions instead of facilitating Tamm transport across membranes (34)(35)(36)(37). However, detailed studies about NH3 vs NH4 + transport capabilities by 'primitive' Rh proteins from invertebrate animals (termed "Rhp") are very scarce.…”

Section: Introductionmentioning

confidence: 99%

A novel nitrogen concentrating mechanism in the coral-algae symbiosome

Thies

Zhouyao

et al. 2021

Preprint

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Corals' algal symbionts are hosted inside the symbiosome of gastrodermal cells, an intracellular compartment that isolates algae from the external environment and allows host cells to control the delivery of metabolites to their symbionts. However, the underlying molecular mechanisms are largely unknown. Here, we report the diel trafficking of NH3-transporting Rhesus (Rh) channels between the cytoplasm and the symbiosome membrane in the coral Acropora yongei, which matches established patterns of nitrogen delivery to endosymbionts. Heterologous expression in Xenopus oocytes established that A. yongei Rh (ayRhp1) is a channel that facilitates NH3 diffusion across membranes following its partial pressure gradient. Immunostaining revealed ayRhp1 is widely distributed throughout coral tissues and most abundantly present in oral ectodermal cells, desmocytes, and gastrodermal cells. In the latter, ayRhp1 was observed in the symbiosome membrane of alga-containing cells. Together with V- type H+-ATPases that make the symbiosome highly acidic (pH~4), ayRhp1 constitutes an NH4+-trapping mechanism analogous to that in mammalian renal tubule. Remarkably, ayRhp1 presence in the symbiosome membrane was higher during the day than the night. This indicates a regulatory mechanism that facilitates NH4+ delivery to alga during the day, likely to sustain high turnover rates of photosynthetic proteins, while restricting NH4+ delivery at night to maintain the endosymbiotic algae in a nitrogen-limited stage that stagnates their growth. The dynamic trafficking of proteins to and away from the symbiosome membrane is a previously unknown mechanism that contributes to metabolic regulation between symbiotic partners.

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Functions of Blood Group Antigens

Cited by 2 publications

References 114 publications

An Insight into the Stages of Ion Leakage during Red Blood Cell Storage

An Insight into the Stages of Ion Leakage during Red Blood Cell Storage

A novel nitrogen concentrating mechanism in the coral-algae symbiosome

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