Functioning of glia and neurodegeneration in Drosophila melanogaster

Mohylyak, Iryna; Chernyk, Y. I.

doi:10.3103/s0095452717030094

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…In both vertebrates and invertebrates, the insulating of axons by glial processes is the only way to increase the conduction velocity of electrical impulses. Therefore, defects in this glial function can cause neurodegenerative diseases [89].…”

Section: Electrical Insulation Of Axonsmentioning

confidence: 99%

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

Kim

Song

Lee

2020

IJMS

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Glial cells are key players in the proper formation and maintenance of the nervous system, thus contributing to neuronal health and disease in humans. However, little is known about the molecular pathways that govern glia–neuron communications in the diseased brain. Drosophila provides a useful in vivo model to explore the conserved molecular details of glial cell biology and their contributions to brain function and disease susceptibility. Herein, we review recent studies that explore glial functions in normal neuronal development, along with Drosophila models that seek to identify the pathological implications of glial defects in the context of various central nervous system disorders.

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Section: Electrical Insulation Of Axonsmentioning

confidence: 99%

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

Kim

Song

Lee

2020

IJMS

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“…Amino acids and small peptides can transit through the blood-brain barrier in Drosophila brain. It is important that almost all molecules transporters in vertebrates have homologs in Drosophila [17,20]. Thus, the human orthologs of SWS NTE protein, is fully functional when expressed in flies [26].…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, glial cells attract more attention in the study of the mechanisms of neurodegeneration and search for the therapeutic approaches. Drosophila has various types of glial cells which play the same role as in the vertebrates: trophic function, regulation of neurotransmitters transport, formation of hemolymph -brain barrier [15,20]. This is why in our research we used flies with altered function of swiss cheese (sws) gene, which is ortholog of human PNPLA6 gene (Patatin Like Phospholipase Domain Containing 6) also known as a NTE (Neuropathy Target Esterase) [18,26].…”

mentioning

confidence: 99%

New Nootropic Preparation From Blood Plasma (Adement): Lack of Therapeutic Influence on Drosophila Neurodegenerative Model

Matiytsiv¹,

Dronska²,

Makarenko³

2018

VLUBS

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Development and research of new neuroactive agents remain relevant because of neurodegenerative diseases incurability. We tested an experimental preparation created from the peptide blood components of Alzheimer's patients in remission period. It was assumed that this product contained autoneuroactive molecules that might have therapeutic or prophylactic potential. Experimental preparation was tested on Drosophila sws-dependent neurodegenerative model. One test system was presented by wild type Oregon R and sws 1 mutants; another one was presented by transgenic lines for UAS-GAL4 controlled knockdown of sws gene in glial cells. Adement and negative control BPAP (blood plasma components of Alzheimer's patients) were fed in two ways: for larvae or on adult stage. The effects of preparations were evaluated by the survival of tested flies. Flies with different genotypes, fed in different ways showed individual survival characteristics in each particular case. How ever, we did not detect any cases of survival increasing; conversely, in some cases Adement reduced survival. The results showed no influence or toxicity effect of Adement on both control individuals and flies with sws-dependent neurodegeneration.

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“…al., 2018). The region of the highest glial cell concentration on histological sections is localized on the retina -lamina boundary and to a lesser extent -on the lamina -medulla boundary (Mohylyak et. al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Сerebrolysin® influences in Sod- and sws-dependent neurodegenerative models of Drosophila melanogaster

Matiytsiv,

Raspopina,

Dronska

et al. 2023

Biol. Stud.

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Background. The incidence of human neurodegenerative disorders increases continuously as the human population ages. To date, these diseases remain incurable and require complex experimental approaches using tractable models to study the degeneration mechanisms and potential drug intervention regimens. In the current work, we assessed the impact of the neuroprotective drug Сerebrolysin on these neurodegenerative processes in Drosophila Sod1 and swiss cheese (sws) mutants. Materials and Methods. The experiments were conducted using a D. melanogaster Sod1- and sws-dependent neurodegeneration model. Сerebrolysin (3 μL/mL) was added for larvae feeding. In order to evaluate Сerebrolysin influence, several tests were performed: locomotor activity assay, lifespan, size of brain tissue degeneration zones and sensitivity to prooxidant exposion. Results. Dietary supplementation with Сerebrolysin extended the lifespan of all flies under normal circumstances. The drug treatment also reduced the sensitivity of mutant flies to pro-oxidant effects. Moreover, treatment with Сerebrolysin partially diminished the size of degeneration zones in the brain tissue of sws1 mutant flies, without any notable effects on locomotor ability. Conclusions. The data obtained confirm the moderate neuroprotective and/or antioxidant action of Сerebrolysinagainst neurodegenerative processes under different genetic backgrounds.

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Functioning of glia and neurodegeneration in Drosophila melanogaster

Cited by 8 publications

References 48 publications

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

New Nootropic Preparation From Blood Plasma (Adement): Lack of Therapeutic Influence on Drosophila Neurodegenerative Model

Сerebrolysin® influences in Sod- and sws-dependent neurodegenerative models of Drosophila melanogaster

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Functioning of glia and neurodegeneration in Drosophila melanogaster

Cited by 8 publications

References 48 publications

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

New Nootropic Preparation From Blood Plasma (Adement): Lack of Therapeutic Influence on Drosophila Neurodegenerative Model

Сerebrolysin® influences in Sod- and sws-dependent neurodegenerative models of Drosophila melano­gaster

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Сerebrolysin® influences in Sod- and sws-dependent neurodegenerative models of Drosophila melanogaster