Functioning lipoadenoma of the parathyroid gland

Leacy, Eric A. de; Axelsen, Roy A.; Kleinman, David S.; Kunze, Hugo E.

doi:10.3109/00313028809085223

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…Parathyroid lipoadenomas are rare and are incidentally detected during thyroid cancer surgery in this case. The article reports 40 cases of parathyroid lipoadenoma reported in PubMed from 1962 to date using the search terms “parathyroid lipoadenoma” and “parathyroid lipoadenoma”, 1 , 2 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 of which 65 cases of parathyroid lipoadenoma were reported (including this case). After excluding 18 cases with missing clinical data, 47 cases had complete clinical data, including 30 females and 17 males, with a female‐to‐male ratio of about 1.8:1, that is, parathyroid lipoadenoma accounted for a higher proportion in females than in males.…”

Section: Discussionmentioning

confidence: 99%

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

Wang,

Chen,

2023

Clinical Case Reports

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Key Clinical MessageParathyroid lipoadenoma is a rare type of parathyroid adenoma, described as a single parathyroid adenoma with more than 50% fat on histologic examination and an unknown etiology, which is one of the rare causes of primary hyperparathyroidism. The difficulty of parathyroid lipoadenoma is mainly diagnosed by preoperative imaging localization. We hope to arouse attention to the parathyroid adenoma which is difficult to locate through our case report. The patient was a middle‐aged male with a body mass index of 38.4 kg/m2 who admitted to our hospital with a 40‐day history of an untreated thyroid nodule. We incidentally discovered parathyroid lipoadenoma in his thyroid surgery. His prognosis was good, and there were no signs of recurrence at his 12‐month follow‐up appointment. We believe that parathyroid lipoadenoma needs to rely on paraffin pathology to make a final diagnosis. This case report serves as a reminder that parathyroid lipoadenomas are also possible in patients who do not have primary hyperparathyroidism preoperatively and who have negative imaging. Clinicians must carefully examine the adipose tissue for the presence of parathyroid lipoadenomas during thyroid surgery to avoid postoperative hypoparathyroidism and persistent hypocalcaemia.

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Section: Discussionmentioning

confidence: 99%

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

Wang,

Chen,

2023

Clinical Case Reports

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“… 1 , 11 There is usually a delicate connective tissue stroma, but often a myxoid stroma is seen as well. It is believed that lipoadenoma is a hyperplastic growth of both endocrine and stromal elements of the parathyroid glands 12 …”

Section: Discussionmentioning

confidence: 99%

“…Twenty-four were discovered at surgery and four at autopsy. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The tumor shows no predilection for sex, with a 1 : 1 female-to-male ratio, and has occurred in a wide range of ages from 41 to 92 years. Unlike parathyroid adenoma, there are no reported cases associated with multiple endocrine neoplasia.…”

mentioning

confidence: 99%

Parathyroid Lipoadenoma: Case Report and Review of the Literature

Turner

Baergen

Pellitteri³

et al. 1996

Otolaryngol.--head neck surg.

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“…9,16,25 Parathyroid lipoadenomas and lipohyperplasias are extremely rare causes of hyperparathyroidism that stand at odds with typical adenomas and hyperplasias with regards to 1 major histologic criterion: these histologic variants are defined by the presence of abundant stromal fat and an increased parathyroid cell mass. Only 47 cases of lipoadenoma 1, [3][4][5]8,[11][12][13][14][15][16]18,20,21,23,26,27,29,[35][36][37]39,40,[43][44][45][46][47] and 6 cases of lipohyperplasia 5,42 have been reported in the English literature. As the majority of these are single case reports, the clinicopathologic features for these entities have been difficult to characterize.…”

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confidence: 99%

Parathyroid Lipoadenomas and Lipohyperplasias

Seethala¹,

Ogilvie

Carty

et al. 2008

American Journal of Surgical Pathology

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Parathyroid lipoadenomas and lipohyperplasias are rare histologic variants with both an increase in stromal fat and parenchyma. We report the most comprehensive single institution series of lipoadenomas and lipohyperplasias to date and review the literature. Eight lipoadenomas and 3 lipohyperplasias (27 y period) were reviewed. The mean age was 60.3 years (range: 50 to 77 y) with a female predilection (1.75:1). The most common symptoms on presentation were fatigue (55.6%) and bone/joint pain (44.4%). Only 1 patient was euparathyroid. Ultrasound localized lipoadenomas in 50% of tested cases whereas sestamibi was successful in 71.4%. Despite increased stromal fat (median: 50%), the weight and the appearance of large, occasionally nodular expansions of parathyroid parenchyma within the fatty stroma distinguished lipoadenomas and lipohyperplasias from normal parathyroid tissue; none of the cases were misclassified as normal on frozen section. Mean weight for lipoadenomas was 1553 mg (range: 173 to 4587 mg), whereas the mean weight for lipohyperplasia glands was 389.1 mg. Variant morphologies included follicular patterned, oxyphil predominant, and thymic elements (thymolipoadenoma). In 1 lipohyperplasia case, not all glands were involved. Oil Red O stains showed decreased intracytoplasmic lipid in most cases. Median follow-up was 9.2 months (range: <1 to 51 mo). Only 1 lipohyperplasia patient had persistent hypercalcemia, but was asymptomatic. Lipoadenomas and lipohyperplasias are clinically similar and as histologically diverse as their conventional counterparts. Lipoadenomas are more difficult to localize preoperatively by imaging. Despite the potential difficulty at frozen section, accurate weight documentation and recognition of key histologic features diminish this challenge.

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Functioning lipoadenoma of the parathyroid gland

Cited by 11 publications

References 5 publications

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

Parathyroid Lipoadenoma: Case Report and Review of the Literature

Parathyroid Lipoadenomas and Lipohyperplasias

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