Functionally separated networks for self-paced and externally-cued motor execution in Parkinson's disease: Evidence from deep brain recordings in humans

Bichsel, Oliver; Gassert, Roger; Stieglitz, Lennart; Uhl, Mechtild; Baumann‐Vogel, Heide; Waldvogel, Daniel; Baumann, Christian; Imbach, Lukas L.

doi:10.1016/j.neuroimage.2018.05.012

Cited by 36 publications

(31 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the magnitude of beta ERD in GPi and PM/M1 are significantly larger for SI movements compared to EC movements during the pre-movement period. This is similar to prior reports that ongoing habitual motor control (i.e., self-paced finger tapping) is associated with a stronger beta desynchronization in STN compared to goal-directed behavior (i.e., externally paced finger tapping) in PD patients ( Bichsel et al, 2018 ). This has been attributed to the clinical observation that habitual motor control is more severely affected in PD ( Redgrave et al, 2010 ).…”

Section: Discussionsupporting

confidence: 91%

“…Finally, the magnitude of low-beta pallidocortical coherence of SI movements correlates with bradykinesia severity. These unique neurophysiological observations linked to SI movements in PD are consistent with clinical observations of impaired SI in PD and are consistent with disruption of circuits related to movement initiation ( Wu et al, 2011 ; Taniwaki et al, 2013 ; Bichsel et al, 2018 ; Jia et al, 2018 ).…”

Section: Discussionsupporting

confidence: 86%

“…Also, Martinu and Monchi (2013) suggested that a connection between sensory cortex and cerebellum may bypass the BGTC pathway when an external cue exists, enabling PD patients to yield almost normal motor performance. Our findings can provide further electrophysiological evidence of segregation of circuits mediating different types of movements, particularly SI vs EC movements ( Bichsel et al, 2018 ).…”

Section: Discussionmentioning

confidence: 56%

“… Bichsel et al (2018) likewise recently reported differences in STN beta activity between EC and SI movements, where SI movements cause a generalized suppression of beta oscillations but EC movements are associated with more dynamic cue-related beta ERD. They also reported spatial segregation of movement related cortical-subcortical synchronicity between EC and SI movements, further supporting the concept that the two types of movements are mediated by functionally separated motor networks in PD patients ( Bichsel et al, 2018 ). While there are a number of studies assessing EC and SI movements, our understanding remains incomplete due to a paucity of circuit-based analyses, clinical correlates, and non-diseased control studies, making it difficult to fully appreciate the role of distinct circuits and oscillatory signals underlying these different motor tasks.…”

Section: Introductionmentioning

confidence: 75%

See 3 more Smart Citations

Altered Pallidocortical Low-Beta Oscillations During Self-Initiated Movements in Parkinson Disease

Choi¹,

Malekmohammadi²,

Sparks³

et al. 2020

Front. Syst. Neurosci.

View full text Add to dashboard Cite

Background Parkinson disease (PD) patients have difficulty with self-initiated (SI) movements, presumably related to basal ganglia thalamocortical (BGTC) circuit dysfunction, while showing less impairment with externally cued (EC) movements. Objectives We investigate the role of BGTC in movement initiation and the neural underpinning of impaired SI compared to EC movements in PD using multifocal intracranial recordings and correlating signals with symptom severity. Methods We compared time-resolved neural activities within and between globus pallidus internus (GPi) and motor cortex during between SI and EC movements recorded invasively in 13 PD patients undergoing deep brain stimulation implantation. We compared cortical (but not subcortical) dynamics with those recorded in 10 essential tremor (ET) patients, who do not have impairments in movement initiation. Results SI movements in PD are associated with greater low-beta (13–20 Hz) power suppression during pre-movement period in GPi and motor cortex compared to EC movements in PD and compared to SI movements in ET (motor cortex only). SI movements in PD are uniquely associated with significant low-beta pallidocortical coherence suppression during movement execution that correlates with bradykinesia severity. In ET, motor cortex neural dynamics during EC movements do not significantly differ from that observed in PD and do not significantly differ between SI and EC movements. Conclusion These findings implicate low beta BGTC oscillations in impaired SI movements in PD. These results provide a physiological basis for the strategy of using EC movements in PD, circumventing diseased neural circuits associated with SI movements and instead engaging circuits that function similarly to those without PD.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 75%

See 2 more Smart Citations

Altered Pallidocortical Low-Beta Oscillations During Self-Initiated Movements in Parkinson Disease

Choi¹,

Malekmohammadi²,

Sparks³

et al. 2020

Front. Syst. Neurosci.

View full text Add to dashboard Cite

show abstract

“…While it is known that beta resynchronizes after a movement, there seems to be no consensus on the existence of beta resynchronization during certain movements intervals. As a supporting finding to ours, previous works have shown that goal-oriented movements lead to beta desynchronizations, but beta modulations during self-paced movements are almost non-existent (Bichsel et al, 2018). In our case, beta resynchronizes during the returning period, coinciding to the switching from a cued movement (reaching) to a non-cued one (returning), as shown in the beta modulations during the off condition.…”

Section: Discussionsupporting

confidence: 91%

Beta-driven closed-loop deep brain stimulation can compromise human motor behavior in Parkinson’s Disease

Iturrate

Martin

Chavarriaga

et al. 2019

Preprint

View full text Add to dashboard Cite

Closed-loop or adaptive deep brain stimulation (DBS) for Parkinson's Disease (PD) has shown comparable clinical improvements to continuous stimulation, yet with less stimulation times and side effects. In this form of control, stimulation is driven by pathological beta oscillations recorded from the subthalamic nucleus, which have been shown to correlate with PD motor symptoms. An important consideration is that beta activity is itself modulated during volitional movements, yet it is unknown the impact that these volitional modulations may have on the efficacy of closed-loop systems. Here, three PD patients performed a functional reaching task during closed-loop stimulation while we measured their motor behavior. Our results show that closed-loop stimulation can alter motor performance at distinct movement intervals. Of particular relevance, closed-loop DBS compromised behavior during the returning period by increasing the amount of submovements executed, and in turn delayed movement termination. Following these findings, we hypothesize that the use of machine learning decoding different movement intervals to fully switch off the stimulator may be beneficial, and present here an exemplary approach decoding the initiation of the movement returning interval above chance level. These findings highlight the importance of evaluating these systems during functional tasks, and the need of extracting more robust biomarkers encoding ongoing symptoms or tasks execution intervals. Abbreviations: DBS: deep brain stimulation LFP: local field potentials PD: Parkinson's disease STN: subthalamic nucleus LMM: linear mixed model UPDRS: Unified Parkinson's Disease rating scale CLDBS: closed-loop deep brain stimulation AUC: area under the receiver-operating characteristic curve

show abstract

Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen

Wang

Deng

et al. 2022

Human Brain Mapping

View full text Add to dashboard Cite

Repetitive transcranial magnetic stimulation (rTMS) has been used in the clinical treatment of Parkinson's disease (PD). Most of rTMS studies on PD used high‐frequency stimulation; however, excessive nonvoluntary movement may represent abnormally cortical excitability, which is likely to be suppressed by low‐frequency rTMS. Decreased neural activity in the basal ganglia on functional magnetic resonance imaging (fMRI) is a characteristic of PD. In the present study, we found that low‐frequency (1 Hz) rTMS targeting individual finger‐tapping activation elevated the amplitude of local neural activity (percentage amplitude fluctuation, PerAF) in the putamen as well as the functional connectivity (FC) of the stimulation target and basal ganglia in healthy participants. These results provide evidence for our hypothesis that low‐frequency rTMS over the individual task activation site can modulate deep brain functions, and that FC might serve as a bridge transmitting the impact of rTMS to the deep brain regions. It suggested that a precisely localized individual task activation site can act as a target for low‐frequency rTMS when it is used as a therapeutic tool for PD.

show abstract

Functionally separated networks for self-paced and externally-cued motor execution in Parkinson's disease: Evidence from deep brain recordings in humans

Cited by 36 publications

References 60 publications

Altered Pallidocortical Low-Beta Oscillations During Self-Initiated Movements in Parkinson Disease

Altered Pallidocortical Low-Beta Oscillations During Self-Initiated Movements in Parkinson Disease

Beta-driven closed-loop deep brain stimulation can compromise human motor behavior in Parkinson’s Disease

Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen

Contact Info

Product

Resources

About