Functionally redundant forms of extended-spectrum beta-lactamases and aminoglycoside-modifying enzymes drive the evolution of two distinct multidrug resistance gene clusters in clinical populations of EXPEC
Abstract:We evaluate the distribution of genetic markers for antibiotic resistance in 276 genomic sequences of Extraintestinal Pathogenic E. coli from two hospitals on the U.S. West coast.Plasmid-borne genes encoding drug-inactivating enzymes dominate the distribution of aminoglycoside and -lactam resistance markers. These genes can be assigned based on their distribution to two mutually exclusive complementarity groups (CGs: CG1 and CG2) with each displaying genetic linkage and minimal functional overlap. CG1 includes… Show more
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