Functionally Defined White Matter Reveals Segregated Pathways in Human Ventral Temporal Cortex Associated with Category-Specific Processing

Gomez, Jesse; Pestilli, Franco; Witthoft, Nathan; Golarai, Golijeh; Liberman, Alina; Poltoratski, Sonia; Yoon, Jennifer M. D.; Grill-Spector, Kalanit

doi:10.1016/j.neuron.2014.12.027

Cited by 171 publications

(199 citation statements)

References 58 publications

Supporting

Mentioning

173

Contrasting

Order By: Relevance

“…AN shows normal activation of TVA, which distinguishes human from non-human sounds. Just as AN shows normal discrimination of voices (Experiment 2), developmental prosopagnosics show normal discrimination of faces (Margalit et al, unpublished), although they are less tolerant than controls in matching faces under conditions of differences in pose and direction of illumination as measured by the Benton test (Gomez et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Developmental phonagnosia: Neural correlates and a behavioral marker

Biederman

Shilowich

et al. 2015

Brain and Language

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Developmental phonagnosia: Neural correlates and a behavioral marker

Biederman

Shilowich

et al. 2015

Brain and Language

View full text Add to dashboard Cite

“…Figure 2 shows the measurements. Statistical analyses were performed by computing a nonpaired t-test along these tract profiles as described in previous studies (Yeatman et al 2012;Ogawa et al 2014;Allen et al 2015;Rykhlevskaia et al 2009;Ajina et al 2015;Leong et al 2016;Gomez et al 2015). We show both a post-mortem anatomical segmentation depicting the known separation of the OR fascicle bundles projecting to fovea and periphery.…”

Section: Anatomy Of White Matter Tracts and Relation To Ophthalmic Exmentioning

confidence: 99%

“…1-2). We measured the white matter tissue along the OT and OR using tract profiles (Yeatman et al 2012;Ogawa et al 2014;Allen et al 2015;Ajina et al 2015;Duan et al 2015;Gomez et al 2015;Leong et al 2016;Libero et al 2016) and the tensor model (Basser and Jones 2002;Basser and Pierpaoli 1998). Supplementary Fig.…”

Section: Visual White Matter and Retinal Damagementioning

confidence: 99%

“…For example, the human white matter is affected during normal aging as well as in age-related diseases, such as Alzheimer's or progressive cognitive degeneration (Mayda et al 2010;Wang et al 2010Wang et al , 2012Yeatman et al 2014; Thomason and Thompson 2011). The visual white matter pathways have been also shown to be affected by visual and eye disease, for example, developmental prosopagnosia (Gomez et al 2015;Thomas et al 2008), amblyopia (Allen et al 2015(Allen et al , 2018Duan et al 2015), and retinal ganglion cell damage (Ogawa et al 2014) have all been reported to affect properties of the human white matter, please see Ariel Rokem et al 2017;Millington et al 2014 for reviews. Evidence from in vivo studies suggest that macular degeneration also affects volume of the human primary visual cortex and the visual pathways (Prins et al 2016a, b;Hernowo et al 2014;Malania et al 2017).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage

et al. 2018

Self Cite

View full text Add to dashboard Cite

We investigated the impact of age-related macular degeneration (AMD) on visual acuity and the visual white matter. We combined an adaptive cortical atlas and diffusion-weighted magnetic resonance imaging (dMRI) and tractography to separate optic radiation (OR) projections to different retinal eccentricities in human primary visual cortex. We exploited the known anatomical organization of the OR and clinically relevant data to segment the OR into three primary components projecting to fovea, mid-and far-periphery. We measured white matter tissue properties-fractional anisotropy, linearity, planarity, sphericity-along the aforementioned three components of the optic radiation to compare AMD patients and controls. We found differences in white matter properties specific to OR white matter fascicles projecting to primary visual cortex locations corresponding to the location of retinal damage (fovea). Additionally, we show that the magnitude of white matter properties in AMD patients' correlates with visual acuity. In sum, we demonstrate a specific relation between visual loss, anatomical location of retinal damage and white matter damage in AMD patients. Importantly, we demonstrate that these changes are so profound that can be detected using magnetic resonance imaging data with clinical resolution. The conserved mapping between retinal and white matter damage suggests that retinal neurodegeneration might be a primary cause of white matter degeneration in AMD patients. The results highlight the impact of eye disease on brain tissue, a process that may become an important target to monitor during the course of treatment.

show abstract

“…Finally, spatial inaccuracies in fMRI limit the effectiveness of 31 studies that combine fMRI with other tools at the neuroscientist's disposal, such as diffusion-weighted 32 imaging (e.g. Gomez et al, 2015) and electrocorticography (e.g. Winawer and Parvizi, 2016).…”

mentioning

confidence: 99%

A critical assessment of data quality and venous effects in ultra-high-resolution fMRI

Kay

Jamison

Vizioli

et al. 2018

Preprint

View full text Add to dashboard Cite

Advances in hardware, pulse sequences, and reconstruction techniques have made it possible to perform 3 functional magnetic resonance imaging (fMRI) at sub-millimeter resolution while maintaining high spatial 4 coverage and acceptable signal-to-noise ratio. Here, we examine whether ultra-high-resolution fMRI can 5 be exploited for routine use in neuroscience research. We conducted fMRI in human visual cortex during 6 a simple event-related visual experiment (7T, gradient-echo EPI, 0.8-mm isotropic voxels, 2.2-s sampling 7 rate, 84 slices), and developed analysis and visualization tools to assess the quality of the data. We make 8 three main observations. First, we find that the acquired fMRI images, combined with appropriate surface-9 based processing, provide reliable and accurate measurements of fine-scale blood oxygenation level 10 dependent (BOLD) activity patterns. Second, we show that the highly folded structure of cortex causes 11 substantial biases on spatial resolution and data visualization. Third, we examine the well-recognized research, we provide practical suggestions for both high-resolution and standard-resolution fMRI studies.

show abstract

Functionally Defined White Matter Reveals Segregated Pathways in Human Ventral Temporal Cortex Associated with Category-Specific Processing

Cited by 171 publications

References 58 publications

Developmental phonagnosia: Neural correlates and a behavioral marker

Developmental phonagnosia: Neural correlates and a behavioral marker

Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage

A critical assessment of data quality and venous effects in ultra-high-resolution fMRI

Contact Info

Product

Resources

About