Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

Abstract

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

Facile Histamine Detection by Surface-Enhanced Raman Scattering Using SiO2@Au@Ag Alloy Nanoparticles

“…The use of a template, such as silica particles or polymer beads, to accumulate silver or gold nanoparticles (NPs) has been widely established in order to control particle size [20][21][22][23][24][25][26][27][28]. Recently, our group produced an Au-Ag alloy on silica nanoparticles as a highly sensitive and reliable SERS probe that can detect molecular targets at very low concentrations [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Based on these studies, we investigated histamine detection using an Au-Ag alloy on silica particles as a material for SERS.…”

Fabrication of pH-sensitive graphene oxide–Benazepril carrier as biosafety controlled release systems

“…[1][2][3][4] One important consideration in designing such carriers is to select an appropriate nanoparticle (NP) carrier that will attach to the transported substance, then retain and slowly release the target substance at a cellular locus where its effectiveness is optimal. 5 BENA is a type of broad-spectrum antihypertension medication that, after cleavage of an ester group in the liver, becomes an angiotensin-converting enzyme (ACE) inhibitor. However, due to poor water solubility, BENA has poor absorption and cellular uptake.…”

“…Effects of different concentrations(1,5,10,20, and 50 mg/L) of GO and GO-BENA on different kinds of cells (a, CACO-2, b, SGC-7901, and c, primary mouse hepatic fibroblast) proliferation (WST-1) and structural integrity (LDH kit). Deionized water (DIW) was used for the control group.…”

Silver Nano/Microparticles: Modification and Applications 2.0

“…Due to this importance of silver materials, the first version of “silver nano/microparticles: modification and applications” was successfully published last year with 10 outstanding papers [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. This version 2.0 of the Special Issue also provides original contributions detailing the synthesis, modification, and applications of silver materials.…”