Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering

Mehrban, Nazia; Zhu, Bangfu; Tamagnini, Francesco; Young, Fraser; Wasmuth, Alexandra; Hudson, Kieran L.; Thomson, Andrew; Birchall, Martin A.; Randall, Andrew D.; Song, Bing; Woolfson, Derek N.

doi:10.1021/acsbiomaterials.5b00051

Cited by 60 publications

(63 citation statements)

References 73 publications

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“…This is not only due to the interesting nano-structures that are formed from the assembly of small molecules but also due to the fact that these supramolecular entities form functional hydrogels under suitable conditions. Gels are endowed with a variety of activities 9 including use as vehicles for drug delivery [10][11][12][13][14] , removal of pollutants and toxic metal ions from waste water [15][16][17][18] , tissue engineering [19][20][21] , making functional nano-hybrid systems [22][23][24] and biocatalysts [25][26][27] . There are many examples of functional hydrogel based on amino acids, peptides, carbohydrates and other biomolecules [28][29][30][31] .…”

Section: Introductionmentioning

confidence: 99%

Amino-Acid-Based Metallo-Hydrogel That Acts Like an Esterase

Gayen

Basu

Bairagi

et al. 2018

ACS Appl. Bio Mater.

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A histidine based amphiphile containing a C14 fatty acyl chain, N-histidyl N-myristry ethyl amine (AM1, 14.7mM) forms hydrogels in the presence of Fe 3+ (within the range 1.47 to 4.41mM) and Hg 2+ (within the range 3.67 to 11.02 mM) ions in aqueous dispersions at pH 6.6 (27C). The imidazole ring of the histidine residue plays a vital role to interact with these metalions. The thermal and mechanical stability of these metallo-hydrogels can be tuned by changing the proportion of amphiphile to metal ion ratio (1:0.1 to 1:0.3 for Fe 3+ containing gel and 1:0.25 to 1:0.75 for Hg 2+ containing gel). The metallo-hydrogels were characterized by different spectroscopic and microscopic techniques, low-and wide-angle powder X-ray diffraction and small-angle X-ray scattering studies. FT-IR and NMR spectroscopic studies indicate the participation of the imidazole ring in metal-ion binding. Low-and wide-angle powder X-ray diffraction and small-angle X-ray scattering data are in favour of a layered structure of the supramolecular assembly of the AM1 in presence of metal-ions. Both, the amphiphiles and the metal ion induced hydrogels reveal catalytic activity of p-nitrophenyl esters hydrolysis for the acetyl, n-butyl and n-octyl esters. Ferric ion containing metallo-hydrogel exhibits higher catalytic activity than the corresponding AM1 aggregate in the absence of metal-ions.

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Section: Introductionmentioning

confidence: 99%

Amino-Acid-Based Metallo-Hydrogel That Acts Like an Esterase

Gayen

Basu

Bairagi

et al. 2018

ACS Appl. Bio Mater.

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“…Recently, a RGD-functionalized α-helix-based hydrogel that combined two peptide sequences, hSAFp1 and hSAFp2, supported the proliferation and migration of murine embryonic neural stem cells. Moreover, signs of neuronal commitment were evidenced by the expression of the microtubule-associated protein-2 (MAP 2), the formation of neuritelike processes and electrophysiological signs (Mehrban et al, 2015).…”

Section: Synthetically Derived Hydrogels For Treatment Of Neuropathymentioning

confidence: 99%

Advanced hydrogels for treatment of diabetes

Reyes-Martínez

Ruíz-Pacheco²,

Flores-Valdéz

et al. 2019

J Tissue Eng Regen Med

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Diabetes mellitus is a chronic disease characterized by high levels of glucose in the blood, which leads to metabolic disorders with severe consequences. Today, there is no cure for diabetes. The current management for diabetes and derived medical conditions, such as hyperglycemia, cardiovascular diseases, or diabetic foot ulcer, includes life style changes and hypoglycemia‐based therapy, which do not fully restore euglycemia or the functionality of damaged tissues in patients. This encourages scientists to work outside their boundaries to develop routes that can potentially tackle such metabolic disorders. In this regard, acellular and cellular approaches have represented an alternative for diabetics, although such treatments still face shortcomings related to limited effectiveness and immunogenicity. The advent of biomaterials has brought significant improvements for such approaches, and three‐dimensional extracellular matrix analogs, such as hydrogels, have played a key role in this regard. Advanced hydrogels are being developed to monitor high blood glucose levels and release insulin, as well as serve as a therapeutic technology. Herein, the state of the art in advanced hydrogels for improving treatment of diabetes, from laboratory technology to commercial products approved by drug safety regulatory authorities, will be concisely summarized and discussed.

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“…Mehrban et al demonstrated that these fibrillar coiled-coils could be decorated with the RGDS cell-adhesive sequence. The resultant hydrogels could promote the growth, directional migration, and differentiation of murine embryonic neural stem cells in culture (Banwell et al 2009;Mehrban et al 2015).…”

Section: Coiled-coil Hydrogelsmentioning

confidence: 99%

Biomaterials Made from Coiled-Coil Peptides

Conticello

Hughes

Modlin

2017

Subcellular Biochemistry

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The development of biomaterials designed for specific applications is an important objective in personalized medicine. While the breadth and prominence of biomaterials have increased exponentially over the past decades, critical challenges remain to be addressed, particularly in the development of biomaterials that exhibit highly specific functions. These functional properties are often encoded within the molecular structure of the component molecules. Proteins, as a consequence of their structural specificity, represent useful substrates for the construction of functional biomaterials through rational design. This chapter provides an in-depth survey of biomaterials constructed from coiled-coils, one of the best-understood protein structural motifs. We discuss the utility of this structurally diverse and functionally tunable class of proteins for the creation of novel biomaterials. This discussion illustrates the progress that has been made in the development of coiled-coil biomaterials by showcasing studies that bridge the gap between the academic science and potential technological impact.

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Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering

Cited by 60 publications

References 73 publications

Amino-Acid-Based Metallo-Hydrogel That Acts Like an Esterase

Amino-Acid-Based Metallo-Hydrogel That Acts Like an Esterase

Advanced hydrogels for treatment of diabetes

Biomaterials Made from Coiled-Coil Peptides

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