Functionalized Zirconium Organic Frameworks as Fluorescent Probes for the Detection of Tetracyclines in Water and Pork

Abstract

The overuse of tetracyclines (TCs) in livestock breeding may cause a series of health and environmental problems. It is necessary to develop more accurate, convenient, and rapid sensing methods toward TCs, but it is still very challenging. In this work, three isostructural zirconium organic frameworks (Zr-MOFs) have been investigated as probes for the fluorescent sensing of TCs in water. By varying the functional group at the central benzene core, their sensing performances toward TCs can be modified. Under optimized conditions, the limit of detection can be as low as 0.08 nM in a wide detection range of 0−147 μM with high sensitivity and selectivity. These Zr-MOFs can also be applied in the detection of TCs in real pork samples with satisfying reliabilities and correctness. This work provides a new method for the design and optimization of fluorescent sensors toward TCs.

Detection Enhancement of One Multifunctional Cd-Metal–Organic Framework toward Tetracycline Antibiotics by Simply Mixing Eu3+ in Suspension

“…The detection limit values of LCU-117 toward OTC whether Eu 3+ was present or not are similar to those of recently reported samples (Table S4). − Time-dependent luminescence has been performed on the Eu 3+ @LCU-117 toward OTC (Figure c). Based on the result, all sensing activities showed fast response within 20 s. As far as we know, Ln 3+ post-modified MOF materials have generally been employed for chemisensors to detect antibiotics or other chemicals. ,− For example, very recently, He’s group reported one Eu 3+ -functionalized MOF named EuUCBA to detect TCs through luminescence quenching, which showed a low detection limit of 0.118 μM toward OTC .…”

“…Tetracycline antibiotics (TCs), the second group of antibiotics consumed worldwide, including tetracycline (TC), chlortetracycline (CTC), and oxytetracycline (OTC), have been widely prescribed for animal and human use because of their broad antibacterial and growth-promoting effects in aquaculture . Some MOFs have been explored to detect TCs. − Discriminative detection among this kind of antibiotics, however, is still challenging.…”

Metal–organic frameworks as a fluorescent probe for detection of pathogenic biomarkers in human urine

“…As HIAA and Eu-MOF compete to absorb UV or visible light, the energy transfer from BTB ligand to Eu 3+ is weakened, resulting in partial fluorescence recovery. [21][22][23] With this mechanism, Eu-MOF functions as a ratiometric fluorescence probe for HIAA detection in urine.…”

Emerging trends and applications of metabolomics in food science and nutrition

“…The first-generation NN is built on computational ideas that, in terms of structure, are comparable to biological neurons and how they might operate as a network. 343,344 Fig. 3 depicts the connection between AI, ML, and DL, and the structure of a straightforward NN, also known as a multilayer perceptron (MLP).…”