Functionalized ZIF‐8 with Aminopropyltrimethoxysilane as Montelukast Sodium Carrier for Medical Application

Abstract

Montelukast sodium (MS) as an anti‐inflammatory agent in asthma requires a drug delivery system to sustain release at specific doses. ZIF‐8 commonly used in drug delivery systems due to its low cytotoxicity and biodegradability was functionalized with 3‐aminopropyltrimethoxysilane (APTES) as a carrier (ZIF‐8@APTES) for MS. The particles were characterized with Field emission scanning electron microscopy (FE‐SEM), Fourier transform infrared (FTIR), X‐ray diffraction (XRD), Brunauer‐Emmett‐Teller (BET) method, and thermogravimetric analysis (TGA). Furthermore, the biocompatibility of ZIF‐8@APTES‐MS on a normal murine cell line (L929) and its antioxidant activity were investigated. The results showed that MS was gradually released from ZIF‐8@APTES‐MS in phosphate buffer solution (pH 7.4) over 6 hours. ZIF‐8@APTES and ZIF‐8@APTES‐MS also had good biocompatibility properties, and significantly (P≤0.05) enhanced total antioxidant activity at high doses (32 μg/mL). In conclusion ZIF‐8@APTES‐MS can be a promising drug delivery system for MS.