Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery

Dubņika, Arita; Loča, Dagnija; Rudoviča, Vita; Parekh, Mansi; Bērziņa-Cimdiņa, Līga

doi:10.1016/j.ceramint.2016.11.214

Cited by 62 publications

(31 citation statements)

References 32 publications

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“…These features enhanced the incorporation of ibuprofen (model drug; 1.38 g/g HAp), dissolution and controlled release of the drug via carbon dioxide. Dubnika et al [274] developed a drug delivery system based on Agdoped HAp and loaded with lidocaine hydrochloride in the presence of chitosan or sodium alginate. Their results suggested that the new hybrid scaffolds have antibacterial activity as well as controlled release of the anesthetic drug for a determined period of time.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

“…Several studies have investigated the effectiveness of dopant use in the structure of hydroxyapatite, as well as the use of scaffolds of these materials, aiming its application in tissue engineering [258,[378][379][380]. Dubnika et al [274] produced HAp-Ag scaffolds to act as a local delivery and delivery system for drugs, functionalized with long-term silver ion release rates. These scaffolds were produced with sodium alginate and chitosan and the rate of in vitro release of the drug into simulated body fluid was evaluated, suggesting that the hybrid material developed has antibacterial activity up to one year, as well as controlled administration of the anesthetic drug up to two weeks.…”

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

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A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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Section: Drug Delivery Systemmentioning

confidence: 99%

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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“…Nevertheless, in implant surgery, the antimicrobial effects of the surgical site is also of outmost importance for the prevention of bacterial infection development. In this case, the administration of an antimicrobial agent at precisely the surgical site is an alternative therapeutic approach [6][7][8][9]. Regularly, both in orthopedics as well as in dentistry, the fixation of the implants with the surrounding tissue is directly related to the contact of the implant with the surrounding tissue.…”

Section: Introductionmentioning

confidence: 99%

Silver-Doped Hydroxyapatite Thin Layers Obtained by Sol-Gel Spin Coating Procedure

et al. 2019

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The main objective of this paper is to develop silver-doped hydroxyapatite suspensions (HApAg) with different concentrations of silver (?Ag = 0.05 and ?Ag = 0.2) in order to obtain uniform and homogenous layers by spin-coating procedure. The colloidal properties of HApAg suspensions are evaluated by dynamic light scattering (DLS) analysis, ζ-potential (ZP), and ultrasound measurements. The ultrasound studies show that the HApAg20 sample revealed better stability than the HApAg5 sample. The structural and morphological analysis on suspensions and thin layers is also conducted. It is observed that the particles of the two samples have a similar shape and are uniform. The layers obtained present a homogeneous appearance of the surface without evidence of cracks or interruption of the coatings. The in vitro antifungal studies conducted on the two thin layers at two different time intervals (24 and 48 h) show that both HApAg5 (?Ag = 0.05) and HApAg20 (?Ag = 0.05) nanoparticles suspensions and composite layers inhibit the development of colony forming units (CFU) even after 24 h of incubation comparative to the control, represented by the Candida albicans (C. albicans) culture in a proper medium. The fungicidal effect was evident after 48 h of incubation in the case of both HApAg20 nanoparticles suspensions and composite layers.

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“…Due to a lower surface concentration of Ag and sensitivity of the HAp-based coatings to external stimuli, coprecipitation of HAp with Ag + would provide more control over the release of Ag from the modified implant surface [57]. HAp crystals start to dissolve at pH less than 6, which would induce enhanced release of Ag in response to a bacterial infection, which is known to create an acidic microenvironment (pH ≤ 5) [58].…”

Section: Sonosynthetic Precipitation Of Hap Onto a Tio 2 Ntmentioning

confidence: 99%

Photochemical Surface Modification of Titanium Dioxide Nanotube-Coated Surfaces by Ag-Hydroxyapatite Compositions

Rashwan

Meyerink

Sereda

et al. 2019

Journal of Chemistry

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Silver-hydroxyapatite coatings prepared from Ag3PO4 microcrystals have been deposited on titanium dioxide nanotubes supported by titanium disks by photodecomposition of predeposited Ag3PO4 microcrystals or their coprecipitate with hydroxyapatite. The SEM-EDS characterization has confirmed excellent film uniformity and consistent deposition over the surface, which is essential for improving osseointegration of tunable antibacterial bone implants.

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Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery

Cited by 62 publications

References 32 publications

A brief review on hydroxyapatite production and use in biomedicine

A brief review on hydroxyapatite production and use in biomedicine

Silver-Doped Hydroxyapatite Thin Layers Obtained by Sol-Gel Spin Coating Procedure

Photochemical Surface Modification of Titanium Dioxide Nanotube-Coated Surfaces by Ag-Hydroxyapatite Compositions

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