Functionalized silica nanoparticles: classification, synthetic approaches and recent advances in adsorption applications

Li, Hao; Chen, Xueping; Shen, Danqing; Wu, Fan; Pleixats, Roser; Pan, Jianming

doi:10.1039/d1nr04048k

Cited by 103 publications

(68 citation statements)

References 197 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nano-sized particles, ranging from tens to several hundreds of nanometer in diameter, and nanotechnology are rapidly sweeping through all the vital fields of science and technology, such as electronics, aerospace, defense, medicine, and catalysis (Li et al, 2021). The nanocarriers employed in nanomedicine are made of less toxic materials, including but not limited to synthetic biodegradable lipids, polymers, and silica.…”

Section: Nanocarrier System For Drug Deliverymentioning

confidence: 99%

Application of Nanomedicine in Inner Ear Diseases

Lin

Guo

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The treatment of inner ear disorders always remains a challenge for researchers. The presence of various physiological barriers, primarily the blood–labyrinth barrier (BLB), limits the accessibility of the inner ear and hinders the efficacy of various drug therapies. Yet despite recent advances in the cochlea for repair and regeneration, there are currently no pharmacological or biological interventions for hearing loss. Current research focuses on the localized drug-, gene-, and cell-based therapies. Drug delivery based on nanotechnology represents an innovative strategy to improve inner ear treatments. Materials with specific nanostructures not only exhibit a unique ability to encapsulate and transport therapeutics to the inner ear but also endow specific targeting properties to auditory hair cells as well as the stabilization and sustained drug release. Along with this, some alternative routes, like intratympanic drug delivery, can also offer a better means to access the inner ear without exposure to the BLB. This review discusses a variety of nano-based drug delivery systems to the ear for treating inner ear diseases. The main factors affecting the curative efficacy of nanomaterials are also discussed. With a deeper understanding of the link between these crucial factors and the clinical effect of nanomaterials, it paves the way for the optimization of the therapeutic activity of nanocarriers.

show abstract

Section: Nanocarrier System For Drug Deliverymentioning

confidence: 99%

Application of Nanomedicine in Inner Ear Diseases

Lin

Guo

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…Silica nanoparticles are one of the most known stable, biocompatible, inert, and non-toxic materials [ 1 , 2 ]. Furthermore, its silanol-rich surface makes it a perfect support for a wide range of applications via anchoring different functional groups [ 2 , 3 , 4 ]. The synthesis of uniform silica nanoparticles with a particle size in the range 100–1000 nm started by hydrolysis condensation of TEOS from aqueous solution catalyzed with ammonium in the early of 1960 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…One effective way of improving hydrophilicity is to anchor the surface with amino groups (SiO 2 –NH 2 ). In addition to this, it is reported that amino groups attached to the surface improve the affinity of the surface to some target molecules such as heavy metal ions, CO 2 , and some biological components [ 2 ]. Pandey et al (2021) anchored 3-aminopropyltrimthoxysilane (APTMS) to the surface of nano-silica to enhance its affinity toward capturing CO 2 [ 9 ], while Zhang et al (2021) anchored 3-aminopropyl) triethoxysilane (APTES) to prepare an efficient adsorbent to extract heparin [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Devlin et al (2021) prepared enzyme-modified silica nanoparticles to attract staphylococcus aureus and disperse biofilms [ 11 ]. Thus, silica nanoparticles have become one of the most attractive materials for different applications such as catalysis, adsorption, chromatography, ceramics, biomedical devices, electronic substances, stabilizers, coating, sensors, and many others [ 1 , 2 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

One-Pot Synthesis of Amine-Functionalized Nano-Silica via Sol-Gel Assisted by Reverse Micelle Microemulsion for Environmental Application

et al. 2022

View full text Add to dashboard Cite

Amine modified nano-silica was prepared via a one-pot route and under very mild conditions in water in oil microemulsion with a non-ionic surfactant to study the effect of changing the amount of N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA) added to the synthesis mixture on the characteristics of the obtained nanocomposite such as morphology, crystallinity, surface charge, particle size, surface area, and accordingly the effect of all of these factors on the efficiency of the nanocomposite for the removal of heavy metal ions, namely zinc, from aqueous solutions. XRD, SEM, TGA, BET, DLS, FTIR, and pH0 analysis were performed for samples and the results showed a strong effect for the amount of DA added to the synthesis mixture on the characteristics of the obtained nanocomposites. It was found that increasing the amount of DA added to the synthesis mixture increased the pH0, hydrodynamic particle size obtained by dynamic light scattering analysis, and the particle size obtained by SEM. Sample prepared without the addition of DA (SNP) and the samples prepared with 1.5 mL of DA (SNP-1.5DA) showed a better adsorption performance compared to the samples prepared with 0.5 and 1.0 mL of DA (SNP-0.5DA and SNP-1.0DA, respectively). The main factor affecting the adsorption efficiency was found to be the available surface area for each nanocomposite, which was directly related to the degree of crystallinity as obtained by XRD analysis.

show abstract

Augmentation of Liquid Metal Particle Mechanics via Non‐Native Oxide Nanoshells

Kong,

Morris,

Farrell

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Room‐temperature liquid metal particles based on gallium have become significantly important for developing next‐generation soft electronics. Eutectic gallium‐indium (EGaIn) alloys can be fabricated into core‐shell particles discretely encapsulated by a passivating oxide. Application of mechanical stimuli results in rupturing the molten core through the oxide shell, merging EGaIn particles to form conductive pathways. Generally, the mechanical properties of EGaIn are largely defined by the native oxide which imparts viscoelastic properties to the fluid. In this work, the practical implications of EGaIn deformation and fracture behavior with the native oxide and a non‐native inorganic silica shell are demonstrated. To augment the mechanical properties of EGaIn, silica nanoshells are introduced as a chemically inert coating to enable brittle fracture of particles. In situ single‐particle nanoindentation characterization reveals the environmental and geometrical considerations for particle deformation and fracture. Silica‐coated EGaIn particles reach stiffness values at least an order of magnitude higher than that of native EGaIn particles. The thickness of the silica shell can be tailored to further modify the mechanical behavior of EGaIn, enabling potential pressure‐sensitive conductivity. These results provide additional pathways to understand the design and implementation of functionalized EGaIn particles for future applications in mechanoresponsive electronics, plasmonics, and therapeutics.

show abstract

Functionalized silica nanoparticles: classification, synthetic approaches and recent advances in adsorption applications

Abstract: Nanotechnology is rapidly sweeping through all the vital fields of science and technology such as electronics, aerospace, defense, medicine, and catalysis. This involves the design, synthesis, characterization, and applications of...

Cited by 103 publications

References 197 publications

Application of Nanomedicine in Inner Ear Diseases

Application of Nanomedicine in Inner Ear Diseases

One-Pot Synthesis of Amine-Functionalized Nano-Silica via Sol-Gel Assisted by Reverse Micelle Microemulsion for Environmental Application

Augmentation of Liquid Metal Particle Mechanics via Non‐Native Oxide Nanoshells

Contact Info

Product

Resources

About