Functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complex

Okur, Nazan; Sarıçam, Canan; Göcek, İkilem; Kalav, Berdan; Şahin, Umut Kıvanç

doi:10.1177/1528083719866933

Cited by 3 publications

(2 citation statements)

References 48 publications

(69 reference statements)

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“…[2][3] Based on these DOI: 10.1002/mame.202200057 advantages, nanofibers have attracted widespread attention and have been increasingly applied in scaffolds for tissue engineering, [4][5][6] drug delivery, [7][8][9] filtration, [10][11][12] adsorption, [13][14][15] energy, [16][17][18] electronic devices, [19][20][21] food packaging, [22][23][24] and other areas. [25][26][27] The commonly used methods for preparing nanofibers include centrifugal spinning, [28][29][30] electrospinning, [31][32][33] pressurized gyration, [34][35][36] self-assembly, [37][38][39] and chemical synthesis. [40][41][42] Among them, electrospinning and centrifugal spinning are the two most effective preparation methods.…”

Section: Introductionmentioning

confidence: 99%

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

Chen

et al. 2022

Macro Materials & Eng

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Nanofibers have received extensive attention in the fields of biomedicine, energy catalysis, environmental sciences, and filtration owing to their high specific surface area and controllable porosity. Electrospinning and centrifugal spinning are the two most effective methods for fabricating nanofibers. However, the low preparation efficiency of electrospinning limits the use of that technology in the large-scale production of nanofibers. The morphology of nanofibers prepared by centrifugal spinning is slightly inferior to electrospinning. Centrifugal electrospinning has great industrial application potential. It is a new method for fabricating nanofibers formed by combining centrifugal and electrostatic forces. It can efficiently fabricate nanofibers with good alignment. In particular, the use of polymer melt as the spinning precursor for centrifugal electrospinning can effectively address the problem of solvent residue in the fiber. In this review, the working principle and device used for centrifugal electrospinning is introduced, the influence of different components of the spinning device on the spinning process is discussed, and the effects of spinning parameters on fiber properties are explained. Then, some applications of nanofibers fabricated are described by centrifugal electrospinning in various areas, including energy, biomedicine, and filtration. Finally, the challenges of centrifugal electrospinning are summarized, and a perspective on future research is provided.

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Section: Introductionmentioning

confidence: 99%

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

Chen

et al. 2022

Macro Materials & Eng

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“…These nanofibers possess the dispersed drug in amorphous or nanocrystalline forms, which increases the solubility and improves the dissolution property of the water-insoluble drugs [ 1 ]. A variety of synthetic and natural polymers have been employed to produce fast-dissolving electrospun nanofibers for successful drug delivery applications including polyvinylpyrrolidone (PVP) [ 1 ], polyvinyl-alcohol (PVA) [ 4 , 5 ], sodium dodecyl sulphate (SDS) [ 6 ], polycaprolactone [ 7 ], chitosan [ 8 , 9 ], gelatin [ 10 , 11 ], pullulan [ 8 ], and cyclodextrin [ 11 , 12 , 13 , 14 ]. These polymeric nanofibers are mainly used to deliver poorly water-soluble bioactives and drugs in a rapid manner.…”

Section: Introductionmentioning

confidence: 99%

Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

et al. 2021

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The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

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Vitamin C fortification: need and recent trends in encapsulation technologies

Maurya,

Shakya,

McClements

et al. 2023

Front. Nutr.

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The multifaceted role of vitamin C in human health intrudes several biochemical functions that are but not limited to antioxidant activity, homoeostasis, amino acid synthesis, collagen synthesis, osteogenesis, neurotransmitter production and several yet to be explored functions. In absence of an innate biosynthetic pathway, humans are obligated to attain vitamin C from dietary sources to maintain its optimal serum level (28 μmol/L). However, a significant amount of naturally occurring vitamin C may deteriorate due to food processing, storage and distribution before reaching to the human gastrointestinal tract, thus limiting or mitigating its disease combating activity. Literature acknowledges the growing prevalence of vitamin C deficiency across the globe irrespective of geographic, economic and population variations. Several tools have been tested to address vitamin C deficiency, which are primarily diet diversification, biofortification, supplementation and food fortification. These strategies inherit their own advantages and limitations. Opportunely, nanotechnology promises an array of delivery systems providing encapsulation, protection and delivery of susceptible compounds against environmental factors. Lack of clear understanding of the suitability of the delivery system for vitamin C encapsulation and fortification; growing prevalence of its deficiency, it is a need of the hour to develop and design vitamin C fortified food ensuring homogeneous distribution, improved stability and enhanced bioavailability. This article is intended to review the importance of vitamin C in human health, its recommended daily allowance, its dietary sources, factors donating to its stability and degradation. The emphasis also given to review the strategies adopted to address vitamin c deficiency, delivery systems adopted for vitamin C encapsulation and fortification.

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Functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complex

Cited by 3 publications

References 48 publications

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Vitamin C fortification: need and recent trends in encapsulation technologies

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