Functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complex

Abstract

In the present study, the electrospinning method was used to develop β–cyclodextrin functionalized polyvinyl alcohol nanofiber webs. The electrospinning parameters were adjusted in order to obtain uniform nanofiber webs by incorporation of varying concentrations of polyvinyl alcohol and β–cyclodextrin in the solutions. Subsequently, β–cyclodextrin/Vitamin C inclusion complexes were added into the polyvinyl alcohol solution, and adjusted parameters were used in the electrospinning process of functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complexes. The formation of nanofiber webs was demonstrated by using Scanning Electron Microscopy. The presence of the inclusion complex in the functionalized electrospun polyvinyl alcohol nanofiber webs was proven by using ultraviolet–visible spectroscopy and Fourier Transform-Infrared Spectroscopy. Consequently, it was achieved to functionalize polyvinyl alcohol electrospun nanofiber webs by incorporating β–cyclodextrin/Vitamin C inclusion complex, which might be considered to have useful applications in cosmetics, personal-care products, and topical drug delivery.

Cyclodextrin Interactions with Water-Soluble Vitamins: Biological Relevance, Stability, Delivery, and Translational Implications—A Critical Review

“…PVA nanofibers have also been prepared by directly adding a nominal 1:1 βCD/vitamin-C solution to the polymer. UV–visible and FTIR changes were used to claim inclusion, but the binary complex was not isolated, and no release or stability study was conducted [ 64 ].…”

Cyclodextrin Interactions with Water-Soluble Vitamins: Biological Relevance, Stability, Delivery, and Translational Implications—A Critical Review

“…PVA nanofibers have also been prepared by directly adding a nominal 1:1 βCD/vitamin-C solution to the polymer. UV–visible and FTIR changes were used to claim inclusion, but the binary complex was not isolated, and no release or stability study was conducted [ 64 ].…”

Vitamin C fortification: need and recent trends in encapsulation technologies

“…The use of polymer fibers for vitamin C encapsulation is still in its infancy, with few published studies in this area. One group developed vitamin C-loaded polyvinyl alcohol/β–cyclodextrin nanofibers suitable for applications in cosmetics, personal-care products, and topical drug delivery ( 297 ). Fish oil/gelatin nanofibers produced by electrospinning have also been used to encapsulate vitamin C ( 298 ).…”

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

“…[2][3] Based on these DOI: 10.1002/mame.202200057 advantages, nanofibers have attracted widespread attention and have been increasingly applied in scaffolds for tissue engineering, [4][5][6] drug delivery, [7][8][9] filtration, [10][11][12] adsorption, [13][14][15] energy, [16][17][18] electronic devices, [19][20][21] food packaging, [22][23][24] and other areas. [25][26][27] The commonly used methods for preparing nanofibers include centrifugal spinning, [28][29][30] electrospinning, [31][32][33] pressurized gyration, [34][35][36] self-assembly, [37][38][39] and chemical synthesis. [40][41][42] Among them, electrospinning and centrifugal spinning are the two most effective preparation methods.…”

Cyclodextrin Interactions with Water-Soluble Vitamins: Biological Relevance, Stability, Delivery, and Translational Implications—A Critical Review

“…PVA nanofibers have also been prepared by directly adding a nominal 1:1 βCD/vitamin-C solution to the polymer. UV–visible and FTIR changes were used to claim inclusion, but the binary complex was not isolated, and no release or stability study was conducted [ 64 ].…”

Vitamin C fortification: need and recent trends in encapsulation technologies

“…The use of polymer fibers for vitamin C encapsulation is still in its infancy, with few published studies in this area. One group developed vitamin C-loaded polyvinyl alcohol/β–cyclodextrin nanofibers suitable for applications in cosmetics, personal-care products, and topical drug delivery ( 297 ). Fish oil/gelatin nanofibers produced by electrospinning have also been used to encapsulate vitamin C ( 298 ).…”

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

“…[2][3] Based on these DOI: 10.1002/mame.202200057 advantages, nanofibers have attracted widespread attention and have been increasingly applied in scaffolds for tissue engineering, [4][5][6] drug delivery, [7][8][9] filtration, [10][11][12] adsorption, [13][14][15] energy, [16][17][18] electronic devices, [19][20][21] food packaging, [22][23][24] and other areas. [25][26][27] The commonly used methods for preparing nanofibers include centrifugal spinning, [28][29][30] electrospinning, [31][32][33] pressurized gyration, [34][35][36] self-assembly, [37][38][39] and chemical synthesis. [40][41][42] Among them, electrospinning and centrifugal spinning are the two most effective preparation methods.…”

Cyclodextrin Interactions with Water-Soluble Vitamins: Biological Relevance, Stability, Delivery, and Translational Implications—A Critical Review

“…PVA nanofibers have also been prepared by directly adding a nominal 1:1 βCD/vitamin-C solution to the polymer. UV–visible and FTIR changes were used to claim inclusion, but the binary complex was not isolated, and no release or stability study was conducted [ 64 ].…”

Vitamin C fortification: need and recent trends in encapsulation technologies

“…The use of polymer fibers for vitamin C encapsulation is still in its infancy, with few published studies in this area. One group developed vitamin C-loaded polyvinyl alcohol/β–cyclodextrin nanofibers suitable for applications in cosmetics, personal-care products, and topical drug delivery ( 297 ). Fish oil/gelatin nanofibers produced by electrospinning have also been used to encapsulate vitamin C ( 298 ).…”

Review of the Principles, Devices, Parameters, and Applications for Centrifugal Electrospinning

“…[2][3] Based on these DOI: 10.1002/mame.202200057 advantages, nanofibers have attracted widespread attention and have been increasingly applied in scaffolds for tissue engineering, [4][5][6] drug delivery, [7][8][9] filtration, [10][11][12] adsorption, [13][14][15] energy, [16][17][18] electronic devices, [19][20][21] food packaging, [22][23][24] and other areas. [25][26][27] The commonly used methods for preparing nanofibers include centrifugal spinning, [28][29][30] electrospinning, [31][32][33] pressurized gyration, [34][35][36] self-assembly, [37][38][39] and chemical synthesis. [40][41][42] Among them, electrospinning and centrifugal spinning are the two most effective preparation methods.…”