Functionalized Platinum Nanoparticles with Biomedical Applications

Rosa, Sagrario Yadira Gutiérrez de la; Diaz, Ramiro Muñiz; Villalobos-Gutiérrez, Paola Trinidad; Patakfalvi, Rita; Coronado, Oscar Gutiérrez

doi:10.3390/ijms23169404

Cited by 24 publications

(15 citation statements)

References 77 publications

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“…PDA, as the main material of this nanocomposite, is a good free radical scavenger because of its rich phenolic groups, which eliminates the ROS produced in inflammatory reactions [ 21 ]. Pt has a high catalase catalytic activity and can thus catalyze hydrogen peroxide and produce oxygen gas, which significantly improves the hypoxia microenvironment of LN and alleviate LN to a certain extent [ 35 ]. To intuitively confirm the change in oxygen level in the kidney area, we carried out a blood oxygen graph of mouse photoacoustic tomography.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

Wang

Han

et al. 2022

Pharmaceutics

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Lupus nephritis (LN) is a common and refractory inflammation of the kidneys caused by systemic lupus erythematosus. Diagnosis and therapies at this stage are inefficient or have severe side effects. In recent years, nanomedicines show great potential for imaging diagnosis and controlled drug release. Herein, we developed a polydopamine (PDA)-based nanocarrier modified with Fe3O4 and Pt nanoparticles and loaded with necrostatin-1 (Nec-1) for the bimodal imaging and therapy of LN. Results demonstrate that Nec-1/PDA@Pt-Fe3O4 nanocarrier exhibits good biocompatibility. Nec-1, as an inhibitor of receptor-interacting protein 1 kinase, can be used to inhibit receptor-interacting protein 1 kinase activity and then reduces inflammation due to LN. Experiments in vitro and in the LN mouse model confirmed that the nanocarrier can reduce neutrophil extracellular traps (NETs) production by RIPK1 and alleviate the progression of inflammation. Previous studies proved that Pt nanoparticles can catalyze H2O2 to produce oxygen. A blood oxygen graph of mouse photoacoustic tomography confirmed that Nec-1/PDA@Pt-Fe3O4 can generate oxygen to fight against the hypoxic microenvironment of LN. PDA and Fe3O4 are used as photographic developers for photoacoustic or magnetic resonance imaging. The preliminary imaging results support Nec-1/PDA@Pt-Fe3O4 potential for photoacoustic/magnetic resonance dual-mode imaging, which can accurately and non-invasively monitor microscopic changes due to diseases. Nec-1/PDA@Pt-Fe3O4 combining these advantages exhibited outstanding performance in LN imaging and therapy. This work offers valuable insights into LN diagnosis and therapy.

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Section: Resultsmentioning

confidence: 99%

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

Wang

Han

et al. 2022

Pharmaceutics

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“…A specific molecule’s conjugation with the surface of nanoparticles can improve penetration into cells by increasing their bioavailability. The functionalization of PtNPs by various molecules possessing a therapeutic effect opens up new possibilities for nanomedicine [ 214 ]. Thus, biosynthesized platinum nanoparticles represent a promising, economical drug for the disease treatment of various etiologies and improving the quality of people’s lives, requiring further study on their physicochemical and biological properties.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Михайлова¹

2022

JFB

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The diverse biological properties of platinum nanoparticles (PtNPs) make them ideal for use in the development of new tools in therapy, diagnostics, and other biomedical purposes. “Green” PtNPs synthesis is of great interest as it is eco-friendly, less energy-consuming and minimizes the amount of toxic by-products. This review is devoted to the biosynthesis properties of platinum nanoparticles based on living organisms (bacteria, fungi, algae, and plants) use. The participation of various biological compounds in PtNPs synthesis is highlighted. The biological activities of “green” platinum nanoparticles (antimicrobial, anticancer, antioxidant, etc.), the proposed mechanisms of influence on target cells and the potential for their further biomedical application are discussed.

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“…Also, studies showed that the presence of platinum nanoparticles when cell cultures were irradiated could result in strongly enhanced breaks in DNA, especially DSBs, mediated by water radicals which may originate from the inner-shell excitation of platinum atoms [50,113,114]. In other studies, Gutiérrez et al [115] discussed the enhanced effect of radiation on cervicaluterine cancer cells (HeLa) when the cancer cells were treated with PEGylated PtNPs functionalized with a fluorescent marker in combination with γ-rays. Results showed that as the radiation dose increased, the number of survived cells decreased in the presence of the nanoparticles.…”

Section: Platinum-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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In recent years, there has been an increasing interest in using nanoparticles in the medical sciences. Today, metal nanoparticles have many applications in medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., and treatment with radiation. This paper reviews recent findings of recent metal nanotheranostics in medical imaging and therapy. The study offers some critical insights into using different types of metal nanoparticles in medicine for cancer detection and treatment purposes. The data of this review study were gathered from multiple scientific citation websites such as Google Scholar, PubMed, Scopus, and Web of Science up through the end of January 2023. In the literature, many metal nanoparticles are used for medical applications. However, due to their high abundance, low price, and high performance for visualization and treatment, nanoparticles such as gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, and lead have been investigated in this review study. This paper has highlighted the importance of gold, gadolinium, and iron-based metal nanoparticles in different forms for tumor visualization and treatment in medical applications due to their ease of functionalization, low toxicity, and superior biocompatibility.

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Functionalized Platinum Nanoparticles with Biomedical Applications

Cited by 24 publications

References 77 publications

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

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