Functionalized nanoscale graphene oxide for high efficient drug delivery of cisplatin

Tian, Lanlan; Pei, Xibo; Zeng, Yongxiang; He, Rui; Li, Zhongjie; Wang, Jian; Wan, Qianbing; Li, Xiaoyu

doi:10.1007/s11051-014-2709-3

Cited by 44 publications

(15 citation statements)

References 52 publications

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“…6C) compared to that of PBS group. These results collectively indicated that pGO was highly biocompatible and could be used as the nanocarrier of dual-drug delivery system, which is consistent with the pGO drug delivery studies 2,4,7,26,36,45 . The possible reasons of the highly biocompatibility of pGO were suggested as follows: (1) Surface modification could enhance biocompatibility.…”

Section: Discussionsupporting

confidence: 85%

“…S2), the L929 cell viability still reached 94.3%. The results indicated that the PEG-functionalized GO is a safe drug carrier 2,4,7,26 . Then, the cell viability of all drug delivery systems and pure drug samples exhibited a dose-dependent pattern after incubation for 24 and 48 h. It is encouraging that the anti-tumor activity of the dual-drug delivery system (pGO-Pt/DOX nanoparticles) In vitro cellular uptake.…”

Section: Gomentioning

confidence: 93%

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PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

Pei

Zhu

Gan

et al. 2020

Sci Rep

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149

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Due to their high specific surface area, graphene oxide and graphene oxide-base nanoparticles have great potential both in dual-drug delivery and combination chemotherapy. Herein, we developed cisplatin (pt) and doxorubicin (DoX) dual-drug-loaded peGylated nano-graphene oxide (pGo) to facilitate combined chemotherapy in one system. In this study, nano-sized pGO-Pt/DOX ranged around 161.50 nm was fabricated and characterized using zeta-potential, AFM, TEM, Raman, UV-Vis, and FTIR analyses. The drug delivery efficacy of Pt was enhanced through the introduction of pGO, and the final weight ratio of DOX: Pt: pGO was optimized to 0.376: 0.376: 1. In vitro studies revealed that pGO-Pt/ DOX nanoparticles could be effectively delivered into tumor cells, in which they induced prominent cell apoptosis and necrosis and exhibited higher growth inhibition than the single drug delivery system or free drugs. The pGO-Pt/DOX induced the most prominent cancer cell apoptosis and necrosis rate with 18.6%, which was observed almost 2 times higher than that of pGO-Pt or pGO-DOX groups. in the apoptosis and necrotic quadrants In vivo data confirmed that the pGO-Pt/DOX dual-drug delivery system attenuated the toxicity of pt and DoX to normal organs compared to free drugs. the tumor inhibition data, histopathology observations, and immunohistochemical staining confirmed that the dual-drug delivery system presented a better anticancer effect than free drugs. These results clearly indicated that the pGO-Pt/DOX dual-drug delivery system provided the means for combination drug delivery in cancer treatment. To improve the efficacy and reduce side effects of anticancer drugs, nanoparticle drug delivery systems (DDSs) have been widely explored in the past few decades 1. Graphene, one of the most popular nanoparticles, has attracted tremendous attentions in the DDSs field due to its unique physical and chemical properties 2. Graphene is a two-dimensional single layer constituted of sp 2-hybridized carbon, which could supply a excellent drug-load ability with its high specific surface area. As a derivatives of graphene, graphene oxide (GO), which could be detected to have hydroxyl, carbonyl, carboxyl and epoxide functional groups on thesurfaces of each shee 3. The presence of those reactive functional groups imparts GO with excellent aqueous solubility, biocompatibility and multi-functionalities, which is essential for the delivery of anticancer drugs 4. Because of the unique properties of graphene oxide (GO), many efforts have been made to load anticancer drugs onto GO efficiently by either non-covalent or covalent bonds 5. For instance, Dai and colleagues 6 first attached hydrophobic aromatic molecules such as a camptothecin analogue (SN38) to the GO surface. The resulting GO-SN38 complex exhibits enhanced solubility and higher anticancer ability than the original SN38 prodrug does. In our previous study 7 , cisplatin (Pt) was carried by PEG-functionalized GO (pGO), and the as-prepared GO-Pt exhibits improved drug loading efficiency and enhance...

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Section: Discussionsupporting

confidence: 85%

Section: Gomentioning

confidence: 93%

PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

Pei

Zhu

Gan

et al. 2020

Sci Rep

Self Cite

149

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“…The therapeutic efficacy of drugs is always related to the drug delivery carrier, which should enable the loading of large doses, controlled release, and retention of the bioactivity of the therapeutic proteins [ 132 ]. At present, anticancer drugs, including doxorubicin [ 133 – 137 ], paclitaxel [ 138 , 139 ], cisplatin [ 140 ], and methotrexate [ 141 , 142 ] loaded by graphene family nanomaterials showed amazing cancerous effect for the selective killing of cancer cells.…”

Section: Graphene Family Materials Mediate Cells Into Osteogenic Diffmentioning

confidence: 99%

Graphene Family Materials in Bone Tissue Regeneration: Perspectives and Challenges

2018

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We have witnessed abundant breakthroughs in research on the bio-applications of graphene family materials in current years. Owing to their nanoscale size, large specific surface area, photoluminescence properties, and antibacterial activity, graphene family materials possess huge potential for bone tissue engineering, drug/gene delivery, and biological sensing/imaging applications. In this review, we retrospect recent progress and achievements in graphene research, as well as critically analyze and discuss the bio-safety and feasibility of various biomedical applications of graphene family materials for bone tissue regeneration.

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“…As a result, extensive research efforts are reported to utilize the favorable and unique properties of carbon-based NPs to create composite materials for various applications, including sensors and actuators, photothermal and photodynamic therapy, diagnostic imaging and drug delivery devices [ 36 , 83 , 84 ]. For example, due to their remarkable mechanical properties, carbon-based NPs have been widely used to incorporate into hydrogels to improve their physical and mechanical properties for a variety of tissue applications [ 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 ]. A great number of studies have demonstrated that a small amount of carbon-based NPs, such as CNTs or graphene, in the polymer matrix can markedly change its mechanical, electrical and thermal properties [ 87 , 88 , 89 , 90 ].…”

Section: Composites Of Hydrogels and Nanoparticlesmentioning

confidence: 99%

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

et al. 2015

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Due to their unique structures and properties, three-dimensional hydrogels and nanostructured particles have been widely studied and shown a very high potential for medical, therapeutic and diagnostic applications. However, hydrogels and nanoparticulate systems have respective disadvantages that limit their widespread applications. Recently, the incorporation of nanostructured fillers into hydrogels has been developed as an innovative means for the creation of novel materials with diverse functionality in order to meet new challenges. In this review, the fundamentals of hydrogels and nanoparticles (NPs) were briefly discussed, and then we comprehensively summarized recent advances in the design, synthesis, functionalization and application of nanocomposite hydrogels with enhanced mechanical, biological and physicochemical properties. Moreover, the current challenges and future opportunities for the use of these promising materials in the biomedical sector, especially the nanocomposite hydrogels produced from hydrogels and polymeric NPs, are discussed.

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Functionalized nanoscale graphene oxide for high efficient drug delivery of cisplatin

Cited by 44 publications

References 52 publications

PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

Graphene Family Materials in Bone Tissue Regeneration: Perspectives and Challenges

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

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