Functionalized iron oxide nanoparticles for controlling the movement of immune cells

White, Ethan E.; Pai, Alex; Weng, Yiming; Suresh, Anil K.; Haute, Desiree Van; Pailevanian, Torkom; Alizadeh, Darya; Hajimiri, Ali; Badie, Behnam; Berlin, Jacob M.

doi:10.1039/c3nr04421a

Cited by 28 publications

(25 citation statements)

References 32 publications

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“…(Reichel, Tripathi, & Perez, 2019;Zanganeh et al, 2016). Finally, in preliminary studies, others have also attempted to drive immune cells (microglia) toward regions of interest by functionalizing them with magnetic nanoparticles (White et al, 2015). Future work may focus on modulating the SPION/immune system interaction to more effectively target tumor cells.…”

Section: Box 1 Vision and Challenges Of Thermally Sensitive Nanocarriersmentioning

confidence: 99%

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Liu

Jang

Issadore

et al. 2019

WIREs Nanomed Nanobiotechnol

129

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Drug delivery strategies aim to maximize a drug's therapeutic index by increasing the concentration of drug at target sites while minimizing delivery to off‐target tissues. Because biological tissues are minimally responsive to magnetic fields, there has been a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control the accumulation and release of drug in target tissues while minimizing the impact on surrounding tissue. In particular, spatially variant magnetic fields have been used to encourage accumulation of drug‐loaded magnetic nanoparticles at target sites, while time‐variant magnetic fields have been used to induce drug release from thermally sensitive nanocarriers. In this review, we discuss nanoparticle formulations and approaches that have been developed for magnetic targeting and/or magnetically induced drug release, as well as ongoing challenges in using magnetism for therapeutic applications. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Section: Box 1 Vision and Challenges Of Thermally Sensitive Nanocarriersmentioning

confidence: 99%

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Liu

Jang

Issadore

et al. 2019

WIREs Nanomed Nanobiotechnol

129

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“…Based on this finding, they formulated CNT-cPG therapy and successfully exerted its anti-tumor activity by promoting the influx of inflammatory cells such as macrophages, nature killer cells, CD8 and CD4 cells [109]. Their recent study has even shown that, through the use of iron oxide nanoparticles, they could control the migration of targeted microglia in vitro under an external magnetic field and could further increase the infiltration of inflammatory macrophage to the brain tumor in vivo [110]. …”

Section: 2 Targeting Microglia/macrophages and Tams In The Cnsmentioning

confidence: 99%

Targeting specific cells in the brain with nanomedicines for CNS therapies

Zhang¹,

Lin²,

Kannan

et al. 2016

Journal of Controlled Release

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Treatment of Central Nervous System (CNS) disorders still remains a major clinical challenge. The Blood-brain-barrier (BBB), known as the major hindrance, greatly limits therapeutics penetration into the brain. Moreover, even though some therapeutics can cross BBB based on their intrinsic properties or via the use of proper nanoscale delivery vehicles, their therapeutic efficacy is still often limited without the specific uptake of drugs by the cancer or disease-associated cells. As more studies have started to elucidate the pathological roles of major cells in the CNS (for example, microglia, neurons, and astrocytes) for different disorders, nanomedicines that can enable targeting of specific cells in these diseases may provide great potential to boost efficacy. In this review, we aim to briefly cover the pathological roles of endothelial cells, microglia, tumor-associated microglia/macrophage, neurons, astrocytes, and glioma in CNS disorders and to highlight the recent advances in nanomedicines that can target specific disease-associated cells. Furthermore, we summarized some strategies employed in nanomedicine to achieve specific cell targeting or to enhance the drug neuroprotective effects in the CNS. The specific targeting at the cellular level by nanotherapy can be a more precise and effective means not only to enhance the drug availability but also to reduce side effects.

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“…When the magnetic particle is smaller than the size of an optical mode, the modulation efficiency is reduced. Although single nanoparticles are desirable in some applications, they commonly accumulate in endosomes into aggregates hundreds of nanometers in size [36], which is on the same scale as optical wavelengths.…”

Section: Discussionmentioning

confidence: 99%

“…A prominent example is magnetic resonance imaging (MRI), which is widely used for full-body human imaging. Coupled with magnetic particles, magnetic fields have also been used for applications such as biomolecule and cell separation [35], cell migration control [36], hyperthermia-based therapy and controlled drug delivery [37], and magnetothermal neural stimulation [38]. Here we use magnetic-field-driven magnetic particles as a new guidestar mechanism.…”

Section: Introductionmentioning

confidence: 99%

Focusing light inside scattering media with magnetic-particle-guided wavefront shaping

Ruan¹,

Haber²,

Liu³

et al. 2017

Optica

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Optical scattering has traditionally limited the ability to focus light inside scattering media such as biological tissue. Recently developed wavefront shaping techniques promise to overcome this limit by tailoring an optical wavefront to constructively interfere at a target location deep inside scattering media. To find such a wavefront solution, a “guide-star” mechanism is required to identify the target location. However, developing guidestars of practical usefulness is challenging, especially in biological tissue, which hinders the translation of wavefront shaping techniques. Here, we demonstrate a guidestar mechanism that relies on magnetic modulation of small particles. This guidestar method features an optical modulation efficiency of 29% and enables micrometer-scale focusing inside biological tissue with a peak intensity-to-background ratio (PBR) of 140; both numbers are one order of magnitude higher than those achieved with the ultrasound guidestar, a popular guidestar method. We also demonstrate that light can be focused on cells labeled with magnetic particles, and to different target locations by magnetically controlling the position of a particle. Since magnetic fields have a large penetration depth even through bone structures like the skull, this optical focusing method holds great promise for deep-tissue applications such as optogenetic modulation of neurons, targeted light-based therapy, and imaging.

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Functionalized iron oxide nanoparticles for controlling the movement of immune cells

Cited by 28 publications

References 32 publications

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Targeting specific cells in the brain with nanomedicines for CNS therapies

Focusing light inside scattering media with magnetic-particle-guided wavefront shaping

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