Functionalized hydrogel–microsphere composites stimulating neurite outgrowth for vascularized bone regeneration

Li, Qian; Zhang, He; Zeng, Ziqian; Yan, Shuang; Hei, Yu; Zhang, Yifei; Chen, Yang; Zhang, Siqi; Wen, Zhang; Wei, Shicheng; Sun, Yuhua

doi:10.1039/d3bm00401e

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…The binding of RGD peptide to integrin receptors plays a significant role in cell adhesion mechanisms [ 62 ]. Previous research has shown that a functionalized hydrogel microsphere (RIBQ) for bone defect repair promotes MSC adhesion and spreading through RGD peptide [ 63 ]. Integrins are widely present in many cells, and studies have shown that integrin receptors are highly expressed on the surface of pro-inflammatory macrophages [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Cell-recruited microspheres for OA treatment by dual-modulating inflammatory and chondrocyte metabolism

Zhou,

He,

Zhang

et al. 2024

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Cell-recruited microspheres for OA treatment by dual-modulating inflammatory and chondrocyte metabolism

Zhou,

He,

Zhang

et al. 2024

Materials Today Bio

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Hydrogel‐Based Systems in Neuro‐Vascularized Bone Regeneration: A Promising Therapeutic Strategy

Li,

Cui,

et al. 2024

Macromolecular Bioscience

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Blood vessels and nerve fibers are distributed throughout the skeletal tissue, which enhance the development and function of each other and have an irreplaceable role in bone formation and remodeling. Despite significant progress in bone tissue engineering, the inadequacy of nerve‐vascular network reconstruction remains a major limitation. This is partly due to the difficulty of integrating and regulating multiple tissue types with artificial materials. Thus, understanding the anatomy and underlying coupling mechanisms of blood vessels and nerve fibers within bone to further develop neuro‐vascularized bone implant biomaterials is an extremely critical aspect in the field of bone regeneration. Hydrogels have good biocompatibility, controllable mechanical characteristics, and osteoconductive and osteoinductive properties, making them important candidates for research related to neuro‐vascularized bone regeneration. This review reports the classification and physicochemical properties of hydrogels, with a focus on the application advantages and status of hydrogels for bone regeneration. We also highlight the effect of neurovascular coupling on bone repair and regeneration and the necessity of achieving neuro‐vascularized bone regeneration. Finally, the recent progress and design strategies of hydrogel‐based biomaterials for neuro‐vascularized bone regeneration are discussed.This article is protected by copyright. All rights reserved

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Functionalized hydrogel–microsphere composites stimulating neurite outgrowth for vascularized bone regeneration

Abstract: Neurovascularized bone regeneration remains an enormous challenge in the clinic.

Cited by 2 publications

References 41 publications

Cell-recruited microspheres for OA treatment by dual-modulating inflammatory and chondrocyte metabolism

Cell-recruited microspheres for OA treatment by dual-modulating inflammatory and chondrocyte metabolism

Hydrogel‐Based Systems in Neuro‐Vascularized Bone Regeneration: A Promising Therapeutic Strategy

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