Functionalized graphene fiber modified by dual nanoenzyme: Towards high-performance flexible nanohybrid microelectrode for electrochemical sensing in live cancer cells

Zhao, Anshun; She, Jun; Wang, Taoqun; Sun, Yimin; Zhang, Yan; Xiao, Fei

doi:10.1016/j.snb.2020.127861

Cited by 47 publications

(16 citation statements)

References 54 publications

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“…Taking advantage of the hierarchical nanohybrid structure and dual nanoenzyme activities, Zhao et al fabricated a graphene fiber electrochemical sensor, modified with MnO 2 -NWs@Au-NPs, for H 2 O 2 detection. The flower-like MnO 2 -NWs showed superior catalytic activity and offered a large surface area for Au-NP decoration [ 56 ].…”

Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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“…Zhao et al developed an amperometry-based electrochemical biosensor and made the diagnosis of cancer by measuring the hydrogen peroxide released from living cancer cells. For this application, they designed a nanohybrid microelectrode-containing graphene fiber (GF) modified with double nanoenzyme MnO 2 -NWs@Au-NPs and prepared with the graphene oxide (GO) starting material of the synthesis [ 113 ] ( Figure 16 ). The preparation of Au nanoparticles (Au-NPs) wrapped in flower-like MnO 2 nanowires (MnO 2 -NWs) was firstly carried out for modification of the fiber coating the microelectrode surface.…”

Section: Introductionmentioning

confidence: 99%

“…[ 115 , 116 ]. In the study [ 113 ], the superior catalytic activity of the microelectrode with a dual nanoenzyme structure was used to provide the basic redox reaction of H 2 O 2 with high efficiency. In this way, real-time analysis of H 2 O 2 released from human breast cancer cells with high sensitivity and selectivity could be performed amperometrically.…”

Section: Introductionmentioning

confidence: 99%

Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics

Ozkan-Ariksoysal

2022

Biosensors

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Since the first commercial biosensor device for blood glucose measurement was introduced in the 1970s, many “biosensor types” have been developed, and this research area remains popular worldwide. In parallel with some global biosensor research reports published in the last decade, including a great deal of literature and industry statistics, it is predicted that biosensor design technologies, including handheld or wearable devices, will be preferred and highly valuable in many areas in the near future. Biosensors using nanoparticles still maintain their very important place in science and technology and are the subject of innovative research projects. Among the nanomaterials, carbon-based ones are considered to be one of the most valuable nanoparticles, especially in the field of electrochemical biosensors. In this context, graphene oxide, which has been used in recent years to increase the electrochemical analysis performance in biosensor designs, has been the subject of this review. In fact, graphene is already foreseen not only for biosensors but also as the nanomaterial of the future in many fields and is therefore drawing research attention. In this review, recent and prominent developments in biosensor technologies using graphene oxide (GO)-based nanomaterials in the field of cancer diagnosis are briefly summarized.

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“…With the recent advance of nanotechnology with biology, a variety of nanozymes, such as carbon-based nanomaterials ( Ji et al, 2021 ; Li et al, 2021 ), transition metal dichalcogenides/peroxides/oxides nanosheets ( Asif et al, 2018a ; Asif et al, 2019 ; Huang et al, 2019 ), noble metal nanoparticles (NPs) ( Shen et al, 2015 ; Xu et al, 2018 ), and their hybrids ( Zhang et al, 2019 ), have been discovered to possess unique enzyme-mimic catalytic activities and used in the biomedicine or bioanalysis by virtue of their reasonable stability, low cost, mass production, and long-term storage properties that are superior to nature enzymes. In the past few years, tremendous research efforts have been devoted to developing nanozyme-modified GF microelectrodes, which have been used in electrochemical detection of versatile biomarkers, such as adrenaline ( Zeng et al, 2019 ), glucose ( Chen et al, 2019 ), dopamine ( Cai et al, 2016 ; Aziz et al, 2019b ), and H 2 O 2 ( Peng et al, 2018 ; Zhao et al, 2020 ; Guo et al, 2021 ). Although considerable progress has been made in this field, it is still a challenge for the development of high-performance functionalized GF-based microelectrodes with optimized microstructural configurations by judiciously selecting electroactive species and rationally designing the composition and structure of nanozyme for continuous detection of biological samples.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H2O2 in Cancer Cells

Huang

Sun

2022

Front. Chem.

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The rational design and construction of high-performance flexible electrochemical sensors based on hierarchical nanostructure functionalized microelectrode systems are of vital importance for sensitive in situ and real-time detection of biomolecules released from living cells. Herein, we report a novel and facile strategy to synthesize a new kind of high-performance microelectrode functionalized by dual nanozyme composed of rime-like Cu2(OH)3NO3 wrapped ZnO nanorods assembly [Cu2(OH)3NO3@ZnO], and explore its practical application in electrochemical detection of hydrogen peroxide (H2O2) released from living cells. Benefiting from the merits of the unique hierarchical nanohybrid structure and high catalytic activities, the resultant Cu2(OH)3NO3@ZnO-modified AGF microelectrode shows remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 1 μM and a high sensitivity of 272 μA cm−2 mM−1, as well as good anti-interference capability, long-term stability, and reproducibility. These properties enabled the proposed microelectrode-based electrochemical platform to be applied for in situ amperometric tracking of H2O2 released from different types of human colon cells, thus demonstrating its great prospect as a sensitive cancer cell detection probe for the early diagnosis and management of various cancer diseases.

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Functionalized graphene fiber modified by dual nanoenzyme: Towards high-performance flexible nanohybrid microelectrode for electrochemical sensing in live cancer cells

Cited by 47 publications

References 54 publications

Recent Progress of Biomarker Detection Sensors

Recent Progress of Biomarker Detection Sensors

Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics

Functionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H2O2 in Cancer Cells

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