Functionalized Eu(III)-Based Nanoscale Metal–Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy

Abstract

The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective and safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a β-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene blue, MB) in the pores and a cyclic peptide targeting motif on the surface of the NMOF, which could achieve highly efficient near-infrared (NIR)-triggered and -targeted photodynamic therapy (PDT). On the basis of the luminescence resonance energy transfer process between the NMOF donor and the photosensitizer MB acceptor, the probe can achieve a high tissue-penetrable TPA-PDT effect. Thus, the NMOFs in this study play the role of not only the nanocontainer for the photosensitizer but also the energy-transfer donor. Studies in vitro show enhanced cellular uptake and satisfactory PDT effectiveness toward cancer cells compared to the free photosensitizer MB. It is highly expected that this study contributes to the development of smart luminescent diagnostic and therapeutic probes.

Nanocontainer in der Analytik

“…[78] Hierbei müssen die Nanocontainer In-vivo-Stabilität, Biokompatibilität, Bioabbaubarkeit und nicht-toxische Eigenschaften aufweisen. [80] Außerdem kann das große Oberfäche-zu-Volumen-Verhältnis der Nanocontainer fürG assensorik genutzt werden, meist mithilfe von Metalloxid-Nanocontainern. [80] Außerdem kann das große Oberfäche-zu-Volumen-Verhältnis der Nanocontainer fürG assensorik genutzt werden, meist mithilfe von Metalloxid-Nanocontainern.…”

“…[80] Die grçßte Hürde fürd ie Nanocontainer kçnnen dabei die Biokompatibilitätund eine mçgliche Toxizitätsein; dieses Problem ist bereits Te il von toxikologischen Studien über Nanomaterialien. [80] Die grçßte Hürde fürd ie Nanocontainer kçnnen dabei die Biokompatibilitätund eine mçgliche Toxizitätsein; dieses Problem ist bereits Te il von toxikologischen Studien über Nanomaterialien.…”

Stimuli‐Responsive Lanthanide‐Based Smart Luminescent Materials for Optical Encoding and Bio‐applications

“…Another strategy to overcome UV or visible light deficiencies was to use rare earth two‐photon complexes to act as a light stimulus response materials. Our group has designed and synthesized a functionalized Eu(III)‐based nanoscale metal‐organic framework, which enabled efficient near‐infrared (NIR)‐triggered and targeted two‐photon absorption photodynamic therapy (Figure ) …”

White‐Light Emission from Dual‐Way Photon Energy Conversion in a Dye‐Encapsulated Metal–Organic Framework

“…In these materials,w hite-light emission is generally produced by aUV-excited one-photon absorption (OPA) process with energy down-conversion. [28][29][30][31][32] However,asfar as we know,nostrategic example has been reported so far to emit reliable TPEF white light. [23] To tackle from another route,t wo-photon excited emission (TPEF) in some organic and metal-organic materials provides an alternative opportunity to achieve multiple colored luminescence as aw hite-light source under NIR excitation.…”

“…[24][25][26][27] Therefore,p hoton color tuning materials by TPEF process are especially applicable in biological, laser, and telecommunication fields. [28][29][30][31][32] However,asfar as we know,nostrategic example has been reported so far to emit reliable TPEF white light. This may be due to multiple reasons.T ypically,f or singlecomponent materials,iti su sually difficult to get broad-band or multiple TPEF emissions covering the whole visible spectrum.…”