Abstract:The Catellani reaction, i.e., the Pd/NBE catalysis, has been evolved into a versatile approach to multisubstituted arenes via the ortho-functionalization/ipso-termination process of a haloarene. Despite significant advances over the past 25 years, this reaction still suffered from an intrinsic limitation in the substitution pattern of the aryl halide, referred to as “ortho-constraint”. When an ortho substituent is absent, the haloarene substrate often fails to undergo effective mono ortho-functionalization pro… Show more
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