Functionalized Cu<sub>3</sub>BiS<sub>3</sub> nanoparticles for dual-modal imaging and targeted photothermal/photodynamic therapy

Wang, Yanke; Cai, Dongdong; Wu, Huixia; Fu, Yu; Cao, Yang; Zhang, Yingjian; Wu, Dongmei; Tian, Qiwei; Yang, Shiping

doi:10.1039/c7nr07458a

Cited by 55 publications

(32 citation statements)

References 47 publications

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“…DAHB@CaP NRs were formulated by the coordination between Ca 2 + and the functional group of dopamine in DAHB using microwave treatment under 120°C for 30 min, followed by surface stabilization with DSPE-mPEG2000 ( Figure 1B). [13] As shown in Figure 3A, the DAHB@CaP NRs had a uniform length and width of 170 � 20 and 20 � 5 nm, respectively. Additionally, the hydrodynamic diameter of DAHB@CaP NRs measured by DLS was about 220.4 nm ( Figure S2).…”

Section: Hypocrellin Derivative-loaded Calcium Phosphate Nanorods As mentioning

confidence: 91%

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

et al. 2019

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Dopamine modified hypocrellin B (DAHB) derivative‐loaded calcium phosphate nanorods (DAHB@CaP NRs) were prepared as a novel phototheranostic agent for effective tumor imaging and therapy. DAHB@CaP NRs were obtained through microwave treatment using DAHB, CaCl2, NH3⋅H2O, and H3PO4 as precursors. The DAHB@CaP NRs possessed the following advantages: 1) efficient absorption in the near‐infrared (NIR) region from 650 nm to 800 nm; 2) maximum NIR emission at approximately 735 nm; 3) enhanced cellular uptake efficiency in vitro and in vivo; and 4) efficient inhibition of tumor growth and low biotoxicity. These properties indicate the high capability of DAHB@CaP NRs for NIR fluorescence (FL) imaging‐guided photodynamic therapy of cancer, thus offering promising new prospects for clinical applications.

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Section: Hypocrellin Derivative-loaded Calcium Phosphate Nanorods As mentioning

confidence: 91%

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

et al. 2019

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“…Each mouse was injected subcutaneously with B16 cells suspended in PBS in the armpit of right forelimb. The length ( L ) and width ( W ) of each tumor were measured at the time of each treatment to work out the tumor volume ( V )

V = \frac{L \times W^{2}}{2}

where the largest and smallest diameters of tumors were used as L and W , respectively.…”

Section: Methodsmentioning

confidence: 99%

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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triggered by near-infrared (NIR) lightexcited photothermal agents [10] while PDT causes the cell death by photosensitizers generating highly cytotoxic reactive oxygen species (ROS) upon light excitation. [11][12][13] With distinct mechanisms of action, the integration of PTT and PDT into one nanoplatform holds great potential to achieve highly efficient cancer therapy. [14][15][16] However, in such combined therapy, two different excitation wavelengths are usually required for the activation of PTT and PDT, [17][18][19] leading to complicated treatment process and prolonged therapeutic time. Thus, it is highly desirable to design a nanoplatform with single NIR light-induced phototherapy.Although strategies of single-wavelength NIR light-mediated PTT/PDT combination therapy have been reported, photothermal agents commonly used in combined systems are inorganic nanomaterials, like gold nanostructures, [20][21][22] MoS 2 nanosheets, [23] black phosphorus nanosheets, [24] and black titania, [25] which show tedious preparation process, poor degradation, difficult excretion, and potential long-term toxicity. NIR organic dyes, which possess unique advantages of outstanding biodegradability and biocompatibility in contrast with inorganic photothermal agents, will be ideal alternatives. Especially, for new indocyanine green (IR820), a structural analog of indocyanine green (ICG), which has been approved by the Food and Drug Administration (FDA) in clinical use, [26][27][28] holds the suitable fluorescence, strong absorption in NIR region, and efficient light-thermal conversion. [29,30] Additionally, it is more stable and easily modified due to the meso-halogen in its chemical structure. Unfortunately, it differs from organic photodynamic agents in intrinsic excitation wavelength, bringing a great challenge to achieve single NIR laser-induced combinational phototherapy. Moreover, it suffers from short half-life in blood, rapid clearance from the body, and lack of specificity to target tumor area. [31,32] Chlorin e6 (Ce6), an FDA-approved second-generation photosensitizer, [33] is extensively used in PDT on account of its high singlet oxygen generation efficiency, [34] near-infrared light excitation allowing deep tissue penetration, and fluorescence imaging capability. [35,36] Despite these upsides, Ce6 has shortcomings including poor water solubility and nonspecific accumulation in tumor sites, [37] which largely compromise Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single-wavelength near-infrared (NIR) light-triggered combinational treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) is still a great challenge. Herein, a multifunctional micelle activated by a single-wavelength laser for simultaneous PTT and PDT as well as fluorescence imaging is developed. Briefly, new indocyanine green (IR820) is conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the linker 6-aminocaproic acid, and then, chlorin e6 (Ce6) is enc...

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“…In addition, Gd-PEG acted as excellent MRI contrast agents by coating gadolinium DTPA-bis-tetradecylamide (Gd-DTPA-BC16). In another work Wang et al [48] conjugated Cu 3 BiS 3 nanoparticles with target ligand folic acid (FA) which can specific receptor overexpressed tumour cells and photosensitizer chlorin e6 (Ce6) which can further form chelate complex with Gd 3+ . They have found that the synthesized Cu (Ce6-Gd 3+ )-FA had effective dual-modal CT/MR imaging capability and excellent in vivo anti-tumour effects achieved by synergistic photothermal/photodynamic therapy.…”

Section: Computed Tomography Scanning (Ct-scan)mentioning

confidence: 99%

A literature review on multimodality molecular imaging nanoprobes for cancer detection

Shahbazi‐Gahrouei

Khaniabadi

Shahbazi-Gahrouei

et al. 2019

Polish Journal of Medical Physics and Engineering

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Molecular imaging techniques using nanoparticles have significant potential to be widely used for the detection of various types of cancers. Nowadays, there has been an increased focus on developing novel nanoprobes as molecular imaging contrast enhancement agents in nanobiomedicine. The purpose of this review article is to summarize the use of a variety of nanoprobes and their current achievements in accurate cancer imaging and effective treatment. Nanoprobes are rapidly becoming potential tools for cancer diagnosis by using novel molecular imaging modalities such as Ultrasound (US) imaging, Computerized Tomography (CT), Single Photon Emission Tomography (SPECT) and Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), and Optical Imaging. These imaging modalities may facilitate earlier and more accurate diagnosis and staging the most of cancers.

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Functionalized Cu₃BiS₃ nanoparticles for dual-modal imaging and targeted photothermal/photodynamic therapy

Cited by 55 publications

References 47 publications

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

A literature review on multimodality molecular imaging nanoprobes for cancer detection

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Functionalized Cu3BiS3 nanoparticles for dual-modal imaging and targeted photothermal/photodynamic therapy

Cited by 55 publications

References 47 publications

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

A literature review on multimodality molecular imaging nanoprobes for cancer detection

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Functionalized Cu₃BiS₃ nanoparticles for dual-modal imaging and targeted photothermal/photodynamic therapy