Functionalized buta-1,3-diynyl- N -methylpyrazoles by sequential “diacetylene zipper” and Sonogashira coupling reactions

Govdi, Anastasia I.; Kulyashova, Alexandra E.; Vasilevsky, S. F.; Балова, Ирина А.

doi:10.1016/j.tetlet.2017.01.032

Cited by 8 publications

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“…Conjugated 1,3-diynes constitute useful and versatile building blocks in the synthesis of natural compounds, pharmaceuticals, π-conjugated polymers, and optoelectronic materials. − Their functionalization occurs mostly via the addition reaction to the unsaturated C–C bonds and can lead to multisubstituted products. ,, The regio- and stereoselectivity of such processes depend on the structure of 1,3-diyne, the second reagent, the catalyst, and the process conditions.…”

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Pt-Catalyzed Hydrosilylation of 1,3-Diynes with Triorganosilanes: Regio- and Stereoselective Synthesis of Mono- or Bis-silylated Adducts

et al. 2019

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An efficient method has been successfully developed for the functionalization of various 1,3-diynes by the hydrosilylation reaction with triethyl- or triphenylsilane catalyzed by Pt catalysts (Pt2(dvs)3, PtO2, or Pt(PPh3)4). Comprehensive optimization studies were performed for the first time to find suitable process conditions for the stereo- and regioselective formation of mono- or bis-silylated adducts from commercially available substrates and catalysts. Silyl-substituted 1,3-enynes or bis-silyl-functionalized buta-1,3-dienes were obtained with excellent yields and fully characterized.

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