Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy

Sharker, Shazid Md.; Kim, Sung Min; Lee, Jung Eun; Choi, Kyung Ho; Shin, Gyojic; Lee, Sangkug; Lee, Kang Dae; Jeong, Ji Hoon; Lee, Haeshin; Park, Soo Jung

doi:10.1016/j.jconrel.2015.09.010

Cited by 86 publications

(66 citation statements)

References 30 publications

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“…The in vivob iocompatibility of the particle was evaluated using histological analysis with hematoxylin and eosin (H&E) staining (Figure7c). [34,35] NIR-mediated cell death was observed only in tumor cells without any noticeable damage to other organs such as the liver,s pleen, heart, lung, and kidney,s uggestive of the biocompatibility of FNP(IR825). We injectedF NP(IR825) at ad ose of 30 mg kg À1 to evaluate the in vivo photothermal conversion potentialb ys ubjecting the animalst oN IR irradiation for 0-5 min.…”

Section: Resultsmentioning

confidence: 99%

Dual‐Responsive Carbon Dot for pH/Redox‐Triggered Fluorescence Imaging with Controllable Photothermal Ablation Therapy of Cancer

et al. 2018

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Herein we describe fluorescence resonance energy transfer (FRET) for a pH/redox-activatable fluorescent carbon dot (FNP) to realize "off-on" switched imaging-guided controllable photothermal therapy (PTT). The FNP is a carbonized self-crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions for cancer therapy. Fluorescence bioimaging was achieved by the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds are reduced, and benzoic imine groups are cleaved under acidic conditions. The release of IR825 from the FNP core in this system may be used to efficiently control PTT-mediated cancer therapy via its photothermal conversion after near-infrared (NIR) irradiation. In vitro and in vivo cellular uptake studies revealed efficient uptake of FNP(IR825) by tumor cells to treat the disease site. In this way we demonstrated in mice that our smart nanocarrier can effectively kill tumor cells under exposure to a NIR laser, and that the particles are biocompatible with various organs. This platform responds sensitively to the exogenous environment inside the cancer cells and may selectively induce the release of PTT-mediated cytotoxicity. Furthermore, this platform may be useful for monitoring the elimination of cancer cells through the fluorescence on/off switch, which can be used for various applications in the field of cancer cell therapy and diagnosis.

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Section: Resultsmentioning

confidence: 99%

Dual‐Responsive Carbon Dot for pH/Redox‐Triggered Fluorescence Imaging with Controllable Photothermal Ablation Therapy of Cancer

et al. 2018

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“…This kind of coatings has the potential to be used on paper, steel, clothes and glass in case of various applications. In this system, drops of water would be gathered without any effect on material (Kim et al, 2016;Sharker et al, 2015;Lee et al, 2014;Nam et al, 2013). An example for self-cleaning glass can be pointed to the National Opera Hall in China (Darmanin and Guittard, 2015).…”

Section: Commercial Applicationsmentioning

confidence: 99%

Recent Progress in Self-Cleaning Materials with Different Suitable Applications

Chermahini¹,

Ostad‐Ali‐Askari²,

Eslamian³

et al. 2018

American Journal of Engineering and Applied Sciences

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Self-cleaning properties have received significant attention for the importance of their potential. Coatings at Nano-scales offer possibilities of using materials for self-cleaning surfaces. Recent efforts have begun to focus on the kinds of materials including metals, semiconductors and polymers. Such materials can have enormous potential in only a few applications. Moreover, the production of these materials requires high costs with low photo activity. In this regard, TiO 2 and its derived materials have shown acceptable and effective suggestions for this application. Moreover, the mechanism of self-cleaning has been explained by the effect of hydrophilic and hydrophobic. Hydrophilic and hydrophobic can have many applications in different areas like water purification, microfluidics and photovoltaic. In this review, the application of self-cleaning in solar cells and environment as well as TiO 2 derived materials and their applications in water management have been briefly illustrated. In addition, it has been explained that a huge number of self-cleaning materials, applications and improvement in utilities have been essential. In short, we have conducted a comprehensive review of the new approach and to mention numerous materials with hydrophobic and hydrophilic properties would be promising for most environmental concerns. Bio-inspired surface respond in nature through hydrophobic (Cicada Wing, Butterfly Wing, Lotus Leaf, Rice Leaf) and hydrophilic (Fish Scale, Snail Shell, Shark Skin) properties was divided in 4 and 3 respectively. Anti reflective coatings with self-cleaning properties have drowned considerable attention for both their basic appearances and vast applied usages. Antireflective coatings with self-cleaning properties have been considered because of their fascinating features and vast diversity of empirical uses.

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“…These materials show ah igh NIRp eak (700-1100 nm), and hence, areu sed widely in the photothermal therapy of cancer.H owever,t he slow and expensive synthesis protocols limit their use to ag reat extent. Some other oxides and composite metaln anomaterials such as WO, [21] CuTe, [22] tellurium platinate, [6] aluminum-doped zinc oxides, [23] conjugated polymers, [24] and others [15,25,26] have also been explored significantlyf or their abilityt oc ook cancerc ellsu sing photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

Comparative Photothermal Performance among Various Sub‐Stoichiometric 2D Oxygen‐Deficient Molybdenum Oxide Nanoflakes and In Vivo Toxicity

Pandey

Sharma

et al. 2018

Chemistry A European J

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The present study deals with photothermal therapy of solid tumors using different forms of oxygen-deficient sub-stoichiometric two-dimensional (2D) molybdenum oxide nanoflakes (α-MoO ). Upon exfoliation of molybdenum oxide power using fine gridding followed by ultrasonication, bluish green molybdenum oxide (BG α-MoO ) was obtained. Oxygen vacancies in BG were generated upon irradiation with an intense xenon lamp. Irradiating the BG for 3 and 5 h, deep blue (B) and olive green (G) oxygen-deficient nanoflakes were obtained respectively. All exhibited high NIR absorption, making these nanomaterials suitable for photothermal therapy. All three forms were functionalized with polypyrrole (PPy@BG, PPy@B, PPy@G) to boost the photothermal stability and transduction efficiency. After functionalization and irradiation with 808 nm laser, the enhancement of temperature for BG, B, G was 50, 65, 52 °C respectively and the corresponding photothermal transduction efficiencies (PTE) were 29.32, 44.42 and 42.00 %. Each of the nanoflakes were found to be highly biocompatible and photostable both in vitro and in vivo. There was substantial decrease in the size of tumors after seven days of treatment on tumor-bearing experimental mice models.

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Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy

Cited by 86 publications

References 30 publications

Dual‐Responsive Carbon Dot for pH/Redox‐Triggered Fluorescence Imaging with Controllable Photothermal Ablation Therapy of Cancer

Dual‐Responsive Carbon Dot for pH/Redox‐Triggered Fluorescence Imaging with Controllable Photothermal Ablation Therapy of Cancer

Recent Progress in Self-Cleaning Materials with Different Suitable Applications

Comparative Photothermal Performance among Various Sub‐Stoichiometric 2D Oxygen‐Deficient Molybdenum Oxide Nanoflakes and In Vivo Toxicity

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