Functionalization with PEG/Angiopep-2 peptide to improve the delivery of gold nanoprisms to central nervous system: in vitro and in vivo studies

Tapia-Arellano, Andreas; Gallardo-Toledo, Eduardo; Ortiz, Camilo; Henríquez, Jonathan; Feijóo, Carmen G.; Araya, Eyleen; Sierpe, Rodrigo; Kogan, Marcelo J.

doi:10.1016/j.msec.2020.111785

Cited by 14 publications

(12 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These properties make AuNPs excellent candidates for the delivery of drugs and active biomolecules. 17,[421][422][423][424] However, before the clinical applications of AuNP-based nanovehicles, much more information is needed about the good manufacturing practice (GMP), pharmacokinetics/absorption, distribution, metabolism, and excretion (PK/ADME), and in vivo toxicity of AuNPs. It is expected that AuNPs will need to be functionalized to reduce their toxicity and target specific diseases.…”

Section: Nanodelivery Vehicles Using Gnss (Drugs Biomolecules and Genes)mentioning

confidence: 99%

Gold nanostructures: synthesis, properties, and neurological applications

Zare¹,

Yaraki

Speranza

et al. 2022

Chem. Soc. Rev.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Nanodelivery Vehicles Using Gnss (Drugs Biomolecules and Genes)mentioning

confidence: 99%

Gold nanostructures: synthesis, properties, and neurological applications

Zare¹,

Yaraki

Speranza

et al. 2022

Chem. Soc. Rev.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Gold nanoparticles are employed in bionanotechnology because they exhibit excellent optoelectronic properties and high surface reactivity, which enable preparation of biocompatible nanomaterials with specific functions [1][2][3][4]. Bioapplications of gold nanoparticles include targeted therapy, molecular delivery, imaging, detection, and theranostics [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

et al. 2021

Self Cite

View full text Add to dashboard Cite

Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.

show abstract

“…48 In accordance with previous reports, in which AuNPs and PEGylated nanoparticles of <100 nm can easily penetrate the blood–brain barrier (BBB), we expected that the prepared PEG-AuNPs@Hyp nanoparticles in the same size range could easily be retained in the brain and act as a suitable targeting agent for GBM treatment. 49…”

Section: Resultsmentioning

confidence: 99%