Functionalization with Interpenetrating Smart Polymer Networks by Gamma Irradiation for Loading and Delivery of Drugs

Muñoz‐Muñoz, Franklin; Bucio, Emilio

doi:10.1002/9781118842843.ch3

Cited by 1 publication

(1 citation statement)

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“…This technique's principle is mainly based on the use of a radioactive isotope ( 60 Co) as a medium for the formation of ionized molecules and free radicals (13). The relevance of this method lies in its low cost and elimination of the use of chemical crosslinkers; furthermore, it promotes a complete reaction between chemical species in the medium and provides a pure and sterile product (14)(15)(16). Among the materials with potential for hydrogels© synthesis, polymers of natural origin such as xanthan gum (XG) and synthetic origin such as polyvinylpyrrolidone (PVP) are included.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation

López-Huante

Prado-Audelo

Caballero-Florán

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Xanthan gum (XG) and polyvinylpyrrolidone (PVP) are two polymers with low toxicity, high biocompatibility, biodegradability, and high hydrophilicity, making them promising candidates for multiple medical aspects. The present work aimed to synthesize a hydrogel from a mixture of XG and PVP and crosslinked by gamma irradiation. We assessed the hydrogel through a series of physicochemical (FT-IR, TGA, SEM, and percentage of swelling) and biological (stability of the hydrogel in cell culture medium) methods that allowed to determine its applicability. The structural evaluation by infrared spectrum demonstrated that a crosslinked hydrogel was obtained from the combination of polymers. The calorimetric test and swelling percentage confirmed the formation of the bonds responsible for the crosslinked structure. The calorimetric test evidenced that the hydrogel was resistant to decomposition in contrast to non-irradiated material.The determination of the swelling degree showed constant behavior over time, indicating a structure resistant to hydrolysis. This phenomenon also occurred during the test of stability in a cell culture medium. Additionally, microscopic analysis of the sample revealed an amorphous matrix with the presence of porosity. Thus, the findings reveal the synthesis of a novel material that has desirable attributes for its potential application in pharmaceutical and biomedical areas.

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Section: Introductionmentioning

confidence: 99%