Functionalization of Polymer Sensor Surfaces by Oxygen Plasma Treatment

Abstract

Methods for the functionalization of polymer biosensor surfaces are applied for the binding of receptors and the sensing of biological particles. In many cases the same biosensor polymer has to perform transduction mechanisms as in the case of optical waveguides. The effects of the functionalization process on the sensor transduction properties like absorption and surface roughness loss should be minimal. In this work we investigate the formation of functional groups by oxygen plasma treatment as a method of precise surface modification for PMMA and SU-8 waveguide materials. Oxygen groups were analyzed by contact angle measurements, XPS, chemical derivatization XPS and fluorescence labeling

Plasma surface modification of polymers for sensor applications

“…Carbonyl groups introduced employing an O 2 plasma can serve as linker groups for protein immobilization through the formation of Schiff bases with the amine groups of proteins to fabricate biosensors. 54,55 Pressure, temperature and humidity sensors Touch sensors have received a great deal of attention in electronics. Indeed, capacitive touch sensors are commonly used in touch screens for many mobile devices, such as smart phones and tablets.…”

High-Q Optical Sensors for Chemical and Biological Analysis

“…O 2 plasma treatment of PMMA, SU-8, polycarbonate, and polystyrene was demonstrated as an effective method to introduce carbonyl, carboxyl, or hydroxyl functionality to polymer devices. 147 Finally, device functionalization using Ni 2+ -nitrolotriacetic acid (Ni-NTA) surface chemistry for immobilization of histidine-tagged proteins provides a useful handle for studying recombinant proteins. Heeres et al synthesized a biotin-tris-NTA molecule to functionalize a streptavidin-coated photonic crystal device, and Ni 2+ -charged surfaces were used to study protein-protein interactions.…”

Design and evaluation of a microcantilever aptasensor

“…Plasma treatment of the SU-8 surface was conducted using a reactor inductively coupled with RF 13.56 MHz [8]. Microcantilever surfaces were dipped in piranha solution for 3 mins, followed by rinsing in DI water for 5 mins.…”