Functionalization of poly(caprolactone) scaffolds by the surface mineralization for use in bone regeneration

Dorj, Biligzaya; Kim, Mi-Kyung; Won, Jong‐Eun; Kim, Hae‐Won

doi:10.1016/j.matlet.2011.07.110

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…A bunch of ionic groups (calcium and phosphate ions) present on the highly ruffled nanomorphology of the mineral nanocrystals should provide strong and abundant binding sites for the proteins. Recent study has also shown the cytochrome C adsorbed onto the HA‐mineralized PCL channel scaffold, which presented a sustainable release profile over a week without any initial burst effect 31. Moreover, the poly(lactide‐ co ‐glycolide) microspheres surface mineralized with biomimetic CaP showed great potential to bind proteins and their sustainable releases.…”

Section: Discussionmentioning

confidence: 99%

Mineralized poly(lactic acid) scaffolds loading vascular endothelial growth factor and the in vivo performance in rat subcutaneous model

Kim

Jin

et al. 2012

J Biomedical Materials Res

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The functionalization of degradable polymeric scaffolds with therapeutic molecules such as vascular endothelial growth factor (VEGF) is a key strategy to gain better regenerative ability of damaged bone tissue by stimulating vascularization and tissue perfusion. Here, we combined VEGF with poly(lactic acid) (PLA) porous scaffold, after modifying the PLA surface with calcium phosphate (CaP) mineral. The mineralized PLA scaffold (mPLA) showed more effective loading capacity of VEGF than the PLA without mineralization as well as profiled sustainable release of VEGF for up to a couple of weeks. The VEGF-loaded mPLA scaffold presented significantly improved proliferation of primary endothelial cells for up to 7 days, with respect to the scaffold without the VEGF loading. The performance of the engineered scaffold was assessed after subcutaneous implantation in rats for 4 weeks. Histological results showed favorable tissue compatibility of both the mPLA scaffolds (with and without VEGF loading), as characterized by infiltration of inflammatory cells, formation of fibrous capsule, and ingrowth of fibroblasts into the matrices. Immunohistochemical staining of the von Willebrand Factor revealed significantly improved formation of neo-capillaries in the VEGF-loaded mPLA. Based on this study, the strategy of VEGF loading onto mineralized PLA scaffold is considered beneficial for gaining improved vascularization of the polymeric scaffolds, suggesting potential applications for bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Mineralized poly(lactic acid) scaffolds loading vascular endothelial growth factor and the in vivo performance in rat subcutaneous model

Kim

Jin

et al. 2012

J Biomedical Materials Res

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“…However, due to the hydrophobicity and lack of active sites (similar as in PLA) needed to attach bioactive molecules, its biological applications are limited. Among the methods used to modify PCL and expanding its applications, the following strategies have been proposed: chemical modification of PCL and surface modification its particles [54,55] the formation of self-assembling copolymers with hydrophilic polymers [56,57], and coating of PCL nanofibers with bioactive materials [58,59]. The alternative way of bioactive sites addition is the preparation of non-covalent ICs of PCL with CDs (α, β, or γ-CD) [60].…”

Section: Polymeric Drug Delivery Systems From Cyclodextrin and Poly(εmentioning

confidence: 99%

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

et al. 2020

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Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

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“…1 It should also have suitable biocompatibility to support cell growth and tissue reconstruction. 2 Moreover, the membrane should have an interconnecting porous microarchitecture, which can act as a physical ow path to enable efficient transport of nutrients, oxygen and metabolic waste in the whole region of the membrane. 1 To fabricate biomedical membranes with desirable properties, various methods such as phase separation, solid freeform fabrication and electrospinning have been used.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of polytetrafluoroethylene nanofibrous membranes for guided bone regeneration

et al. 2018

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Functionalization of poly(caprolactone) scaffolds by the surface mineralization for use in bone regeneration

Cited by 11 publications

References 11 publications

Mineralized poly(lactic acid) scaffolds loading vascular endothelial growth factor and the in vivo performance in rat subcutaneous model

Mineralized poly(lactic acid) scaffolds loading vascular endothelial growth factor and the in vivo performance in rat subcutaneous model

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Fabrication of polytetrafluoroethylene nanofibrous membranes for guided bone regeneration

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