Functionalization of Magnetic Nanowires for Active Targeting and Enhanced Cell-Killing Efficacy

Alsharif, Nouf; Aleisa, Fajr A.; Liu, Guangyu; Ooi, Boon S.; Patel, Niketan S.; Ravasi, Timothy; Merzaban, Jasmeen S.; Kosel, Jürgen

doi:10.1021/acsabm.0c00312

Cited by 19 publications

(9 citation statements)

References 69 publications

(174 reference statements)

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“…Nanospinners can exert mechanical forces under a rotating magnetic field at 15 Hz and 40 mT to target the mitochondria of cancer cells [580]. Iron nanowires that are functionalized with anti-CD44 antibodies have been used in a combination therapy that included magnetomechanical and photothermal treatments on colon cancer cells [581]. Hedgehog-like microspheres that were composed of needle-like MNP with carbon and gold double shells seriously damaged cancer cells and strongly inhibited tumor growth through mechanical force [582].…”

Section: Magnetomechanical Methods For Cancer Therapymentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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Section: Magnetomechanical Methods For Cancer Therapymentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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“…The addition of active targeting compositions on these nanowires could produce a multifunctional tool to boost therapy efficacies through the combination of magnetic field treatments and specific target. Due to expression of the glycoprotein CD44 in about 90% of colon cancer cells, Fe NMWs were functionalised with anti‐CD44 antibodies for a combination therapy under magnetomechanical and photothermal treatments on colon cancer cells, leading to a 3‐fold increase of Fe NMWs internalisation in colon cancer cells compared to control cells, and the increased efficacy of killing from 35% of individual therapies alone to more than 71% of the combination therapy [129].…”

Section: Medical Applicationsmentioning

confidence: 99%

Preparation, properties and biomedical applications progress of 1D magnetic nanomaterials with iron

Huang,

Wang,

et al. 2023

Biosurface and Biotribology

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Abstract1D magnetic nanomaterials with iron, with the special physical properties and biological behaviour, have been found to possess the great promising applications in many fields. In this review, the components, structure, physicochemical properties, biocompatibility and in vitro and in vivo biomedical functions of magnetic nanowires (MNWs), nanorods (MNRs) with iron are summarised, especially their anisotropy shape and magnetism result in their many applications in biodetections and medical treatment fields. The potential future functions of these 1D magnetic nanomaterials compared to magnetic nanoparticles also is discussed by highlighting the possibility of integration with other metal‐compositions or bio‐compositions and with existing biotechnology as well as by pointing out their specific properties. Current limitations in the property improvement and issues related with the outcome of the MNRs in the body are also summarised in order to address the remaining challenge for the extended biomedical functions of MNRs in the clinical application field.

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“…Studies have demonstrated that SIONs can effectively deliver cisplatin, curcumin, lauric acid, mitoxantrone, artemisinin, docetaxel, paclitaxel, dopamine, 10-hydroxycamptothecin, docetaxel, DOX, rifampicin, tetracycline hydrochloride, and other drugs ( Nagesh et al, 2016 ; Prakash et al, 2019 ; Vangijzegem et al, 2019 ). In addition, a few peptides, antibodies, or organic small molecules, such as amino-terminal fragment peptide ( Yang et al, 2009 ), anti-HER2/neu peptide ( Mu et al, 2015 ), anti-CD44 antibody ( Alsharif et al, 2020 ), prostate specific membrane antigen ( Bandini et al, 2017 ), β-cyclodextrin ( Sudha et al, 2016 ), and pluronic F127 polymer ( Khodaei et al, 2022 )were conjugated on the SION surfaces, consequently enhancing the targeting function of the SIONs delivery system, increasing the specificity and therapeutic effect.…”

Section: Classification Of Mnpsmentioning

confidence: 99%

Metal-based nano-delivery platform for treating bone disease and regeneration

Liu

Xu²,

Qiao³

et al. 2022

Front. Chem.

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Owing to their excellent characteristics, such as large specific surface area, favorable biosafety, and versatile application, nanomaterials have attracted significant attention in biomedical applications. Among them, metal-based nanomaterials containing various metal elements exhibit significant bone tissue regeneration potential, unique antibacterial properties, and advanced drug delivery functions, thus becoming crucial development platforms for bone tissue engineering and drug therapy for orthopedic diseases. Herein, metal-based drug-loaded nanomaterial platforms are classified and introduced, and the achievable drug-loading methods are comprehensively generalized. Furthermore, their applications in bone tissue engineering, osteoarthritis, orthopedic implant infection, bone tumor, and joint lubrication are reviewed in detail. Finally, the merits and demerits of the current metal-based drug-loaded nanomaterial platforms are critically discussed, and the challenges faced to realize their future applications are summarized.

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Functionalization of Magnetic Nanowires for Active Targeting and Enhanced Cell-Killing Efficacy

Cited by 19 publications

References 69 publications

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Preparation, properties and biomedical applications progress of 1D magnetic nanomaterials with iron

Metal-based nano-delivery platform for treating bone disease and regeneration

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