Functionalization of hydrophobic surfaces with antimicrobial peptides immobilized on a bio-interfactant layer

Corrales-Ureña, Yendry Regina; Souza-Schiaber, Ziani; Lisboa‐Filho, Paulo Noronha; Marquenet, Florian; Noeske, Michael; Gätjen, Linda; Rischka, Klaus

doi:10.1039/c9ra07380a

Cited by 17 publications

(21 citation statements)

References 51 publications

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“… 64 The peak at 286.3 eV could be assigned to the carbon atoms of the C=O or C–N 65 , 66 or to the O=C—N. 64 , 67 The amide related peak at 288.08 eV, 67 , 68 observed only for the functionalized sample, confirms the presence of peptides.…”

Section: Resultsmentioning

confidence: 85%

Short Ligand, Cysteine-Modified Warnericin RK Antimicrobial Peptides Favor Highly Sensitive Detection of Legionella pneumophila

et al. 2021

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Culture-based methods for the detection of Legionella pneumophila are prohibitively slow and frequently inadequate. The problem has been addressed with biosensing technology that employs a variety of ligands for the specific capture of bacteria. However, the limited success of the application of mammalian antibodies, aptamers, and nucleic acid-based probes for sensitive biosensing has generated growing interest in exploring alternative biosensing architectures, such as those based on antimicrobial peptides (AMP) that are known for their attractive therapeutic applications. We report on the successful employment of cysteinemodified warnericin RK AMP for the operation of a highly sensitive biosensor of L. pneumophila based on digital photocorrosion of GaAs/AlGaAs nanoheterostructures. The replacement of the relatively cumbersome procedure commonly applied for the attachment of antibodies to COOH-terminated mercaptohexadecanoic acid self-assembled monolayers has allowed for a significant reduction in the distance at which bacteria are immobilized above the biosensor surface. An important consequence of this approach is the attractive limit of detection of L. pneumophila estimated at 2 × 10 2 CFU/mL. The target bacteria were captured four times more efficiently than P. fluorescens, B. subtilis, and E. coli, which is highly promising for environmental monitoring.

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Section: Resultsmentioning

confidence: 85%

Short Ligand, Cysteine-Modified Warnericin RK Antimicrobial Peptides Favor Highly Sensitive Detection of Legionella pneumophila

et al. 2021

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“…Direct incorporation, coating, or immobilization are the main strategies [ 100 ]. Various methods are proposed in literature, such as cold plasma treatment [ 101 ], enzyme (laccase) surface modification [ 102 ], adsorption on nanoparticles [ 103 ] etc.…”

Section: Antimicrobial Packaging Obtained By Modification Of Currementioning

confidence: 99%

Biodegradable Antimicrobial Food Packaging: Trends and Perspectives

Motelică

Ficai

et al. 2020

Foods

206

134

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This review presents a perspective on the research trends and solutions from recent years in the domain of antimicrobial packaging materials. The antibacterial, antifungal, and antioxidant activities can be induced by the main polymer used for packaging or by addition of various components from natural agents (bacteriocins, essential oils, natural extracts, etc.) to synthetic agents, both organic and inorganic (Ag, ZnO, TiO2 nanoparticles, synthetic antibiotics etc.). The general trend for the packaging evolution is from the inert and polluting plastic waste to the antimicrobial active, biodegradable or edible, biopolymer film packaging. Like in many domains this transition is an evolution rather than a revolution, and changes are coming in small steps. Changing the public perception and industry focus on the antimicrobial packaging solutions will enhance the shelf life and provide healthier food, thus diminishing the waste of agricultural resources, but will also reduce the plastic pollution generated by humankind as most new polymers used for packaging are from renewable sources and are biodegradable. Polysaccharides (like chitosan, cellulose and derivatives, starch etc.), lipids and proteins (from vegetal or animal origin), and some other specific biopolymers (like polylactic acid or polyvinyl alcohol) have been used as single component or in blends to obtain antimicrobial packaging materials. Where the package’s antimicrobial and antioxidant activities need a larger spectrum or a boost, certain active substances are embedded, encapsulated, coated, grafted into or onto the polymeric film. This review tries to cover the latest updates on the antimicrobial packaging, edible or not, using as support traditional and new polymers, with emphasis on natural compounds.

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“…Consequently, finding alternative therapies strategies is desirable to overcome and treat biofilm-based infections [ 38 ]. Therefore, natural antimicrobial peptides (AMPs) and their synthetic derivatives have acquired considerable attention as effective agents in various pathologies [ 61 ] through their broad spectrum of activity against bacterial (Gram-negative and Gram-positive bacteria, including drug resistant strains) and fungal microorganisms associated with low toxicity to mammalian cells, small molecular size and high stability [ 62 , 63 , 64 ].…”

Section: Surface Functionalization With Antimicrobial Peptidesmentioning

confidence: 99%

Lactoferrin Functionalized Biomaterials: Tools for Prevention of Implant-Associated Infections

Páll

Roman

2020

Antibiotics

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Tissue engineering is one of the most important biotechnologies in the biomedical field. It requires the application of the principles of scientific engineering in order to design and build natural or synthetic biomaterials feasible for the maintenance of tissues and organs. Depending on the specific applications, the selection of the proper material remains a significant clinical concern. Implant-associated infection is one of the most severe complications in orthopedic implant surgeries. The treatment of these infections is difficult because the surface of the implant serves not only as a substrate for the formation of the biofilm, but also for the selection of multidrug-resistant bacterial strains. Therefore, a promising new approach for prevention of implant-related infection involves development of new implantable, non-antibiotic-based biomaterials. This review provides a brief overview of antimicrobial peptide-based biomaterials—especially those coated with lactoferrin.

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Functionalization of hydrophobic surfaces with antimicrobial peptides immobilized on a bio-interfactant layer

Abstract: A bio-interfactant layer is applied on hydrophobic surfaces to immobilize antimicrobial peptides.

Cited by 17 publications

References 51 publications

Short Ligand, Cysteine-Modified Warnericin RK Antimicrobial Peptides Favor Highly Sensitive Detection of Legionella pneumophila

Short Ligand, Cysteine-Modified Warnericin RK Antimicrobial Peptides Favor Highly Sensitive Detection of Legionella pneumophila

Biodegradable Antimicrobial Food Packaging: Trends and Perspectives

Lactoferrin Functionalized Biomaterials: Tools for Prevention of Implant-Associated Infections

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