Functionalization of graphenic surfaces by oxygen plasma toward enhanced wettability and cell adhesion: experiments corroborated by molecular modelling

Gołda-Cępa, Monika; Kumar, Divya; Białoruski, Marek; Lasota, Sławomir; Madeja, Zbigniew; Piskorz, Witold; Kotarba, Andrzej

doi:10.1039/d3tb00536d

Cited by 4 publications

(3 citation statements)

References 53 publications

(80 reference statements)

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“…However, the presence of more polar groups (such as urea groups) with increasing R -values resulted in an increase in the surface polarity of the material and a slight decrease in the contact angle, in agreement with the FTIR-ATR split-peak data, which may be related to the increase in the number of polar groups on the surface. 48…”

Section: Resultsmentioning

confidence: 99%

Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption

Zhen,

Zhang,

Wang

et al. 2024

J. Mater. Chem. A

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Section: Resultsmentioning

confidence: 99%

Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption

Zhen,

Zhang,

Wang

et al. 2024

J. Mater. Chem. A

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“…The greatest change in the intensity can be observed in the case of the long oxygen plasma pre-treatment. It can be concluded that oxygen plasma modification forms (among others) hydroxyl groups onto the surface [ 25 , 26 ], which subsequently react with HMDS vapors during the hydrophobization process. Kodaira et al [ 27 ] deposited HMDS films onto the glass plates using an atmospheric plasma torch from a mixture of HMDS, argon, and air.…”

Section: Resultsmentioning

confidence: 99%

Hydrophobization of Cold Plasma Activated Glass Surfaces by Hexamethyldisilazane Treatment

Terpiłowski,

Chodkowski,

Pakhlov

et al. 2024

Molecules

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The objective of this study was to investigate the modification of glass surfaces by the synergistic combination of cold plasma and chemical surface modification techniques. Glass surface hydrophobicity was obtained as a result of various plasma and deposition operational conditions. The mechanisms governing the hydrophobization process were also studied. Glass plates were activated with plasma using different gases (oxygen and argon) at different treatment times, ranging from 30 to 1800 s. Then, the plasma-treated surfaces were exposed to hexamethyldisilazane vapors at different temperatures, i.e., 25, 60, and 100 °C. Complete characterization, including contact angle measurements, surface free energy calculations, 3D profilometry, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy, was accomplished. It was found that the extent of the hydrophobicity effect depends on both the plasma pre-treatment and the specific conditions of the hexamethyldisilazane deposition process. Plasma activation led to the formation of active sites on the glass surface, which promoted the adsorption and reaction of hexamethyldisilazane species, thereby inducing surface chemical modification. Longer plasma pre-treatment resulted in stronger modification on the glass surface, resulting in changes in the surface roughness. The largest water contact angle of ≈100° was obtained for the surface activated by argon plasma for 1800 s and exposed to hexamethyldisilazane vapors at 25 °C. The changes in the surface properties were caused by the introduction of the hydrophobic trimethylsilyl groups onto the glass surface as well as roughness development.

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“…The incorporation of nanotechnology into medical research marks a significant advancement, especially in the development of innovative therapeutic strategies. − This is particularly visible in the judicious integration of nanomaterials with biological mechanisms, which holds the promise of transforming the way diseases are treated at both the molecular and cellular scales. − The use of two-dimensional (2D) carbon-based materials, such as graphene (G) and/or GO, is increasingly being explored in the context of treating a variety of ailments, including cancer, gastrointestinal infections, and neurodegenerative diseases, like AD and PD, etc. − …”

Section: Introductionmentioning

confidence: 99%

Bio-Nano Synergy in Therapeutic Applications: Drug–Graphene Oxide Nanocomposites for Modulated Acetylcholinesterase Inhibition and Radical Scavenging

Phanrang,

Upadhyaya,

Chandra

et al. 2024

J. Phys. Chem. B

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The current study explores the synergistic application of biophysical chemistry and nanotechnology in therapeutic treatments, focusing specifically on the development of advanced biomaterials to repurpose FDA-approved Alzheimer's disease (AD) drugs as potent antioxidants. By integration of AD drugs into graphene oxide (GO) nanocomposites, an attempt to enhance the acetylcholinesterase (AChE) inhibition and increase radical scavenging activity is proposed. This bionano synergy is designed to leverage the unique properties of both the nanomaterial surface and the bioactive compounds, improving treatment effectiveness. The nanocomposites also promise targeted drug delivery, as GO can traverse the blood−brain barrier to inhibit AChE more effectively in AD patients. Furthermore, the drug−GO nanocomposite exhibits enhanced radical scavenging capabilities, offering additional therapeutic benefits. This study also elucidates a molecular level understanding on how the properties of the drugs are modified when integrated into nanocomposites with GO, enabling the development of more effective materials. The interdisciplinary approach presented in this study exploits the potential of nanotechnology to enhance drug delivery systems and achieve superior therapeutic outcomes through bionano synergy.

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Functionalization of graphenic surfaces by oxygen plasma toward enhanced wettability and cell adhesion: experiments corroborated by molecular modelling

Abstract: Graphenic materials attract huge attention because of their outstanding properties, showing wide applications as, i.a., components of biomaterials. Due to their hydrophobic nature, however, the surfaces need to be functionalized...

Cited by 4 publications

References 53 publications

Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption

Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption

Hydrophobization of Cold Plasma Activated Glass Surfaces by Hexamethyldisilazane Treatment

Bio-Nano Synergy in Therapeutic Applications: Drug–Graphene Oxide Nanocomposites for Modulated Acetylcholinesterase Inhibition and Radical Scavenging

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