Functionalization of Flavonoids (Quercetin) to Chitosan Matrix and Determination of Antioxidant Activity of Obtained Bio-composites

Gonţa, Maria; Sirbu, Elena; Robu, Ştefan; Gonta, Alexandru; Mocanu, Larisa

doi:10.1007/978-3-030-31866-6_66

Cited by 2 publications

(1 citation statement)

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“…Thus, interest in using quercetin as a medicinal or supplementary ingredient has grown rapidly. Quercetin has been reported to exhibit high antioxidant, antitumor, antiinflammatory, antimicrobial, antibacterial and antiviral activity (D'Andrea, 2015;Gonta et al, 2020;Lesjak, 2018;Lin & Zhou, 2018;Pal & Tripathi, 2020a, 2020bWang et al, 2016;Xu et al, 2019). Additionally, it has also been reported to exhibit antithrombotic, anti-aggregator and vasodilating activity (Chondrogianni et al, 2010;Chopra et al, 2000;Erlund et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Formulation and Caracterization of Quercetin Niosome With Concentration Variations of Span 20 Surfactant

Bhagawan

Annisa

Maulidya

2021

J.Pharm.Sci.Community

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Quercetin has low solubility, absorption and bioavailability which limits its practical use as a drug or supplement. Therefore, it is important to formulate a quercetin niosome system with various concentrations of span 20 as a surfactant. This investigation aimed to formulate and analyse a quercetin niosome preparation with span 20 variations to provide optimal quercetin solubility. Niosomes were prepared using various concentrations of span 20. In the present study, the quercetin niosome used the reverse phase evaporation (RPE) method. Quercetin niosome is characterised by its organoleptic properties, pH value, particle morphology comprising the particle shape and size, and encapsulation efficiency. Organoleptic observations of the quercetin niosome included a yellow colour, distinctive quercetin odour and thick consistency for all formulas. The pH remained within the physiological pH range of skin. Quercetin niosome morphology was close to spherical while the niosome particle size results were 2.13 µm (F1), 2.99 µm (F2) and 3.31 µm (F3). The quercetin niosome encapsulation efficiency results were 81.86 ± 0.47% (F1), 84.02 ± 0.26% (F2) and 88.24 ± 0.10% (F3). Quercetin niosome were successfully prepared using multiple span 20 concentrations below the cholesterol concentration characterised by the measurement results of organoleptic, pH, particle morphology and encapsulation efficiency.

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Section: Introductionmentioning

confidence: 99%

Formulation and Caracterization of Quercetin Niosome With Concentration Variations of Span 20 Surfactant

Bhagawan

Annisa

Maulidya

2021

J.Pharm.Sci.Community

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Synthesis of quercetin functionalized chitosan and determination of antioxidant properties

Gonţa¹,

Duca²,

Sirbu³

et al. 2023

Chem. J. Mold.

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This paper is dedicated to the synthesis of a copolymer with reducing properties obtained by functionalizing chitosan with quercetin and determining the antioxidant activity of the derivatives obtained depending on the molar mass of the polymer. For this purpose, low molecular weight chitosan was obtained by oxidizing commercial chitosan with hydrogen peroxide and further functionalization with quercetin by the covalent grafting method. The functionalization process was performed through the following steps: functionalization of chitosan with ethyl chloroformate to increase the reactivity of the amine group to the hydroxyl group of quercetin and grafting the quercetin molecule to the synthesized intermediate. The comparative antioxidant properties of the composite obtained by grafting technical chitosan with quercetin and by grafting low molecular weight chitosan were studied by the DPPH (2,2-diphenyl-1-picrylhydrazyl radical) method. The obtained results indicate that a decrease in the molecular weight of chitosan contributed to its grafting with quercetin. As a result, the functionalized polymer composite acquired a higher antioxidant activity and can be successfully used to inhibit the oxidation of various organic substrates in the cosmetic, food and pharmaceutical industries.

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Functionalization of Flavonoids (Quercetin) to Chitosan Matrix and Determination of Antioxidant Activity of Obtained Bio-composites

Cited by 2 publications

References 10 publications

Formulation and Caracterization of Quercetin Niosome With Concentration Variations of Span 20 Surfactant

Formulation and Caracterization of Quercetin Niosome With Concentration Variations of Span 20 Surfactant

Synthesis of quercetin functionalized chitosan and determination of antioxidant properties

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